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- W4313705352 abstract "Abstract Introduction The age adjusted Charlson Comorbidity Index (aCCI) is the most widely used prognostic tool in patients with comorbidity. Our aim is to evaluate its relationship with postoperative morbidity and mortality. Methods Retrospective observational analysis of 145 patients >80 years with CRC operated upon between 2018–2020 in a tertiary center with 2-year follow-up. Pre- and postoperative variables such as aCCI, tumor stage and location, Clavien-Dindo and 2-year survival were selected. Survival analysis was performed according to Kaplan-Meier and ROC curves to predict postoperative mortality/complications. To determine association, a Cox univariate regression model was used. Results The mean age was 86 years, the right colon was the most frequent tumor location and laparoscopy was the predominant approach. Only 12.4% presented major complications (Clavien-Dindo >=3). There was no statistically significant association between aCCI and surgical complications HR 1.118 (p 0.095), and there was a relationship with the development of medical complications OR 1.28 (p 0.020) with a sensitivity of 71% and a cut-off point of aCCI 7.5 AUC 0. 637. Overall survival at 2 years was 79% (26 deaths). We did not find a statistically significant association between aCCI and mortality (p 0.286), a weak predictor AUC 0.582. Conclusions Elevated aCCI is not related to a higher risk of postoperative morbidity and mortality and has little predictive capacity for surgical complications; however, aCCI >7 is associated with a higher probability of medical complications. Prospective studies are needed to include multivariable analyses associated with aCCI." @default.
- W4313705352 created "2023-01-08" @default.
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- W4313705352 date "2023-01-04" @default.
- W4313705352 modified "2023-10-16" @default.
- W4313705352 title "USEFULNESS OF THE AGE-ADJUSTED CHARLSON COMORBIDITY INDEX AS A PREDICTOR OF MORBIDITY AND MORTALITY IN PATIENTS OVER 80 YEARS OF AGE WITH COLORECTAL CANCER" @default.
- W4313705352 doi "https://doi.org/10.1093/bjs/znac443.056" @default.
- W4313705352 hasPublicationYear "2023" @default.
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