Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313705929> ?p ?o ?g. }
- W4313705929 endingPage "78" @default.
- W4313705929 startingPage "68" @default.
- W4313705929 abstract "Heart failure is caused by various factors, making the underlying pathogenic mechanisms difficult to identify. Since cardiovascular disease tends to worsen over time, early diagnosis is key for treatment. In addition, understanding the qualitative changes in the heart associated with aging, where information on the direct influences of aging on cardiovascular disease is limited, would also be useful for treatment and diagnosis. To fill these research gaps, the focus of our study was to detect the structural and functional molecular changes associated with the heart over time, with a focus on glycans, which reflect the type and state of cells.We investigated glycan localization in the cardiac tissue of normal mice and their alterations during aging, using evanescent-field fluorescence-assisted lectin microarray, a technique based on lectin-glycan interaction, and lectin staining.The glycan profiles in the left ventricle showed differences between the luminal side (medial) and wall side (lateral) regions. The medial region was characterized by the presence of sialic acid residues. Moreover, age-related changes in glycan profiles were observed at a younger age in the medial region. The difference in the age-related decrease in the level of α-galactose stained with Griffonia simplicifolia lectin-IB4 in different regions of the left ventricle suggests spatiotemporal changes in the number of microvessels.The glycan profile, which retains diverse glycan structures, is supported by many cell populations, and maintains cardiac function. With further research, glycan localization and changes have the potential to be developed as a marker of the signs of heart failure." @default.
- W4313705929 created "2023-01-08" @default.
- W4313705929 creator A5000505927 @default.
- W4313705929 creator A5011169770 @default.
- W4313705929 creator A5027281595 @default.
- W4313705929 creator A5044712859 @default.
- W4313705929 creator A5045224580 @default.
- W4313705929 creator A5055616588 @default.
- W4313705929 creator A5062868302 @default.
- W4313705929 creator A5065566375 @default.
- W4313705929 creator A5067453676 @default.
- W4313705929 creator A5067737824 @default.
- W4313705929 creator A5068874449 @default.
- W4313705929 creator A5074803551 @default.
- W4313705929 creator A5077694828 @default.
- W4313705929 date "2023-03-01" @default.
- W4313705929 modified "2023-10-18" @default.
- W4313705929 title "Spatiotemporal changes of tissue glycans depending on localization in cardiac aging" @default.
- W4313705929 cites W104325304 @default.
- W4313705929 cites W1964022624 @default.
- W4313705929 cites W1970203561 @default.
- W4313705929 cites W1972453474 @default.
- W4313705929 cites W1982569158 @default.
- W4313705929 cites W2000624583 @default.
- W4313705929 cites W2008962114 @default.
- W4313705929 cites W2013840481 @default.
- W4313705929 cites W2015376846 @default.
- W4313705929 cites W2027272551 @default.
- W4313705929 cites W2075979086 @default.
- W4313705929 cites W2106125829 @default.
- W4313705929 cites W2110417357 @default.
- W4313705929 cites W2137647114 @default.
- W4313705929 cites W2139905522 @default.
- W4313705929 cites W2142194547 @default.
- W4313705929 cites W2161260472 @default.
- W4313705929 cites W2193792657 @default.
- W4313705929 cites W2286685388 @default.
- W4313705929 cites W2322684075 @default.
- W4313705929 cites W2417864863 @default.
- W4313705929 cites W2593698072 @default.
- W4313705929 cites W2606607751 @default.
- W4313705929 cites W2619646918 @default.
- W4313705929 cites W2620914886 @default.
- W4313705929 cites W2624021648 @default.
- W4313705929 cites W2792058853 @default.
- W4313705929 cites W2795134170 @default.
- W4313705929 cites W2889358636 @default.
- W4313705929 cites W2898186258 @default.
- W4313705929 cites W2908974911 @default.
- W4313705929 cites W2946318004 @default.
- W4313705929 cites W2965922790 @default.
- W4313705929 cites W2967369308 @default.
- W4313705929 cites W2984854823 @default.
- W4313705929 cites W3007643904 @default.
- W4313705929 cites W3010441732 @default.
- W4313705929 cites W3011483812 @default.
- W4313705929 cites W3012824401 @default.
- W4313705929 cites W3013800395 @default.
- W4313705929 cites W3014067025 @default.
- W4313705929 cites W3015190630 @default.
- W4313705929 cites W3016808868 @default.
- W4313705929 cites W3045608202 @default.
- W4313705929 cites W3088401235 @default.
- W4313705929 cites W3117139588 @default.
- W4313705929 cites W3179857518 @default.
- W4313705929 cites W3206517050 @default.
- W4313705929 doi "https://doi.org/10.1016/j.reth.2022.12.009" @default.
- W4313705929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36712959" @default.
- W4313705929 hasPublicationYear "2023" @default.
- W4313705929 type Work @default.
- W4313705929 citedByCount "1" @default.
- W4313705929 countsByYear W43137059292023 @default.
- W4313705929 crossrefType "journal-article" @default.
- W4313705929 hasAuthorship W4313705929A5000505927 @default.
- W4313705929 hasAuthorship W4313705929A5011169770 @default.
- W4313705929 hasAuthorship W4313705929A5027281595 @default.
- W4313705929 hasAuthorship W4313705929A5044712859 @default.
- W4313705929 hasAuthorship W4313705929A5045224580 @default.
- W4313705929 hasAuthorship W4313705929A5055616588 @default.
- W4313705929 hasAuthorship W4313705929A5062868302 @default.
- W4313705929 hasAuthorship W4313705929A5065566375 @default.
- W4313705929 hasAuthorship W4313705929A5067453676 @default.
- W4313705929 hasAuthorship W4313705929A5067737824 @default.
- W4313705929 hasAuthorship W4313705929A5068874449 @default.
- W4313705929 hasAuthorship W4313705929A5074803551 @default.
- W4313705929 hasAuthorship W4313705929A5077694828 @default.
- W4313705929 hasBestOaLocation W43137059291 @default.
- W4313705929 hasConcept C104317684 @default.
- W4313705929 hasConcept C108625454 @default.
- W4313705929 hasConcept C126322002 @default.
- W4313705929 hasConcept C142724271 @default.
- W4313705929 hasConcept C150194340 @default.
- W4313705929 hasConcept C186836561 @default.
- W4313705929 hasConcept C206212055 @default.
- W4313705929 hasConcept C2778198053 @default.
- W4313705929 hasConcept C2778921608 @default.
- W4313705929 hasConcept C2780115458 @default.
- W4313705929 hasConcept C2780758401 @default.