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• W4313705949 endingPage "109686" @default.
• W4313705949 startingPage "109686" @default.
• W4313705949 abstract "Alcohol abuse may lead to the development of gastric mucosal lesions. Dapagliflozin (DAPA), a sodium-glucose cotransporter-2 inhibitor, is clinically used to treat type 2 diabetes mellitus. However, studies showed protective effect of DAPA under various experimental conditions by alleviating oxidative stress and inflammation. The effect of DAPA on experimental gastric ulcer has not been studied yet. Therefore, we attempted to investigate DAPA's protective effect against ethanol (EtOH)-induced gastric lesions. Fifty-six (8-week-old) male Wistar rats were divided into seven groups. DAPA (1, 5, and 10 mg/kg/day; p.o.) was given for seven days, plus a single dose of absolute EtOH (5 ml/kg) on day 8. According to hematoxylin and eosin, and Alcian blue staining of gastric tissue sections, titratable acidity, and macroscopic assessments, DAPA high dose (10 mg/kg) was the most protective, with lesser ulcerations, and higher mucin, relative to the lower two doses and the standard treatment omeprazole (OME). In rats pre-treated with DAPA high dose, colorimetric and ELISA analyses revealed significantly decreased oxidative stress, pro-inflammatory, and apoptosis indices and increased levels of platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF). Western blot analysis revealed reduced pentraxin-3 (PTX3), high-mobility group box 1 (HMGB1), receptor for advanced glycation end products (RAGE), toll-like receptor 4 (TLR4), and myeloid differentiation factor 88 (MyD88) expression. These results were comparable in DAPA (10 mg/kg) and OME pre-treated groups. Overall, DAPA exerted a dose-dependent protective effect against EtOH-induced gastric injury. Gastroprotective effects of DAPA (10 mg/kg) may be associated with influencing HMGB1/RAGE/PTX3 and TLR4/MyD88/VEGF/PDGF pathways." @default.
• W4313705949 created "2023-01-08" @default.
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• W4313705949 date "2023-02-01" @default.
• W4313705949 modified "2023-10-13" @default.
• W4313705949 title "Gastroprotective effect of dapagliflozin in ethanol-induced gastric lesions in rats: Crosstalk between HMGB1/RAGE/PTX3 and TLR4/MyD88/VEGF/PDGF signaling pathways" @default.
• W4313705949 cites W1480979919 @default.
• W4313705949 cites W1557836391 @default.
• W4313705949 cites W1584008083 @default.
• W4313705949 cites W1850974052 @default.
• W4313705949 cites W1883072153 @default.
• W4313705949 cites W1964774089 @default.
• W4313705949 cites W1966342049 @default.
• W4313705949 cites W1968046099 @default.
• W4313705949 cites W1969244190 @default.
• W4313705949 cites W1987751135 @default.
• W4313705949 cites W2003011341 @default.
• W4313705949 cites W2018324845 @default.
• W4313705949 cites W2019831441 @default.
• W4313705949 cites W2028483738 @default.
• W4313705949 cites W2035294846 @default.
• W4313705949 cites W2051883205 @default.
• W4313705949 cites W2053054955 @default.
• W4313705949 cites W2062709088 @default.
• W4313705949 cites W2065132423 @default.
• W4313705949 cites W2066519344 @default.
• W4313705949 cites W2074464351 @default.
• W4313705949 cites W2087560219 @default.
• W4313705949 cites W2100650274 @default.
• W4313705949 cites W2136269345 @default.
• W4313705949 cites W2137793506 @default.
• W4313705949 cites W2152047404 @default.
• W4313705949 cites W2154658221 @default.
• W4313705949 cites W2155208388 @default.
• W4313705949 cites W2167242692 @default.
• W4313705949 cites W2261645960 @default.
• W4313705949 cites W2261667678 @default.
• W4313705949 cites W2322083498 @default.
• W4313705949 cites W2416826340 @default.
• W4313705949 cites W2460277376 @default.
• W4313705949 cites W2468325702 @default.
• W4313705949 cites W2510080164 @default.
• W4313705949 cites W2528588222 @default.
• W4313705949 cites W2540977893 @default.
• W4313705949 cites W2548555233 @default.
• W4313705949 cites W2619123244 @default.
• W4313705949 cites W2761905894 @default.
• W4313705949 cites W2766513700 @default.
• W4313705949 cites W2782959446 @default.
• W4313705949 cites W2806009760 @default.
• W4313705949 cites W2899586829 @default.
• W4313705949 cites W2914687932 @default.
• W4313705949 cites W2944523362 @default.
• W4313705949 cites W2946176860 @default.
• W4313705949 cites W2984760880 @default.
• W4313705949 cites W2999945678 @default.
• W4313705949 cites W3002109560 @default.
• W4313705949 cites W3012358187 @default.
• W4313705949 cites W3013047499 @default.
• W4313705949 cites W3016818408 @default.
• W4313705949 cites W3035708383 @default.
• W4313705949 cites W3037653703 @default.
• W4313705949 cites W3046932676 @default.
• W4313705949 cites W3081602884 @default.
• W4313705949 cites W3082123511 @default.
• W4313705949 cites W3083089620 @default.
• W4313705949 cites W3093471194 @default.
• W4313705949 cites W3116421626 @default.
• W4313705949 cites W3119898605 @default.
• W4313705949 cites W3120851875 @default.
• W4313705949 cites W3127553611 @default.
• W4313705949 cites W3130369152 @default.
• W4313705949 cites W3162759792 @default.
• W4313705949 cites W3163302553 @default.
• W4313705949 cites W3169937201 @default.
• W4313705949 cites W3172210189 @default.
• W4313705949 cites W3186298241 @default.
• W4313705949 cites W3213097578 @default.
• W4313705949 cites W4200232577 @default.
• W4313705949 cites W4211029205 @default.
• W4313705949 cites W4221099999 @default.
• W4313705949 cites W4280531243 @default.
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• W4313705949 cites W4293247451 @default.
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• W4313705949 doi "https://doi.org/10.1016/j.intimp.2023.109686" @default.
• W4313705949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36623411" @default.
• W4313705949 hasPublicationYear "2023" @default.
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