FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313706457> ?p ?o ?g. }

• W4313706457 endingPage "844" @default.
• W4313706457 startingPage "835" @default.
• W4313706457 abstract "ABSTRACT Background The use of direct oral anticoagulants (DOAC) in patients with non-valvular atrial fibrillation (NVAF) and advanced chronic kidney disease (CKD) including dialysis is growing. Several studies have shown favorable results of DOAC compared with warfarin regarding bleeding risk but no difference in stroke protection. However, these studies had poor time in therapeutic range (TTR), in the warfarin comparison group. Methods This was a Swedish national cohort study investigating the risk of ischemic stroke and major bleeding on DOAC compared with warfarin in patients with NVAF, glomerular filtration rate category 3–5D (G3–G5D), kidney transplant recipients excluded, between 2009 and 2018. Data extracted from high-quality national healthcare registries including the Swedish Renal Registry, AuriculA (the Swedish national quality register for AF and anticoagulation) and The Stroke Register. Results At enrolment, of 2453 patients 59% were treated with warfarin (mean TTR 67%) and 41% with DOAC. Overall, 693 (28.3%) had G3, 1113 (45.4%) G4, 222 (9.1%) G5 and 425 (17.3%) G5D. DOAC compared with warfarin showed lower hazard of major bleeding [hazard ratio 0.71 (95% confidence interval 0.53–0.96)] but no difference in ischemic stroke risk. Mortality was increased during DOAC treatment [1.24 (1.01–1.53)], presumably not a causal association since fewer fatal bleedings occurred on DOAC. Conclusions DOAC treatment, compared with warfarin, is associated with almost 30% lower risk of bleeding in patients with NVAF and CKD G3–G5D. The stroke risk is comparable between the treatments. This is the first study comparing DOAC and well-managed warfarin (TTR 67%) in advanced CKD. Ongoing and planned randomized controlled trials need to confirm the possible benefit of DOAC." @default.
• W4313706457 created "2023-01-08" @default.
• W4313706457 creator A5023850849 @default.
• W4313706457 creator A5038271770 @default.
• W4313706457 creator A5060197628 @default.
• W4313706457 creator A5066137311 @default.
• W4313706457 creator A5088605272 @default.
• W4313706457 date "2023-01-05" @default.
• W4313706457 modified "2023-10-18" @default.
• W4313706457 title "Direct oral anticoagulants versus warfarin in patients with non-valvular atrial fibrillation and CKD G3–G5D" @default.
• W4313706457 cites W1586488555 @default.
• W4313706457 cites W2060630424 @default.
• W4313706457 cites W2092332131 @default.
• W4313706457 cites W2096246254 @default.
• W4313706457 cites W2097854437 @default.
• W4313706457 cites W2122337725 @default.
• W4313706457 cites W2136489990 @default.
• W4313706457 cites W2141761576 @default.
• W4313706457 cites W2152412672 @default.
• W4313706457 cites W2162508946 @default.
• W4313706457 cites W2162586165 @default.
• W4313706457 cites W2166018731 @default.
• W4313706457 cites W2338521299 @default.
• W4313706457 cites W2897495391 @default.
• W4313706457 cites W2957544571 @default.
• W4313706457 cites W2985219892 @default.
• W4313706457 cites W3001164020 @default.
• W4313706457 cites W3011312705 @default.
• W4313706457 cites W3026961475 @default.
• W4313706457 cites W3082188176 @default.
• W4313706457 cites W3095490894 @default.
• W4313706457 cites W3127371152 @default.
• W4313706457 cites W3139113952 @default.
• W4313706457 cites W3154284764 @default.
• W4313706457 cites W4207026671 @default.
• W4313706457 cites W4281898201 @default.
• W4313706457 cites W4308365855 @default.
• W4313706457 doi "https://doi.org/10.1093/ckj/sfad004" @default.
• W4313706457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37151425" @default.
• W4313706457 hasPublicationYear "2023" @default.
• W4313706457 type Work @default.
• W4313706457 citedByCount "1" @default.
• W4313706457 countsByYear W43137064572023 @default.
• W4313706457 crossrefType "journal-article" @default.
• W4313706457 hasAuthorship W4313706457A5023850849 @default.
• W4313706457 hasAuthorship W4313706457A5038271770 @default.
• W4313706457 hasAuthorship W4313706457A5060197628 @default.
• W4313706457 hasAuthorship W4313706457A5066137311 @default.
• W4313706457 hasAuthorship W4313706457A5088605272 @default.
• W4313706457 hasBestOaLocation W43137064571 @default.
• W4313706457 hasConcept C126322002 @default.
• W4313706457 hasConcept C127413603 @default.
• W4313706457 hasConcept C159641895 @default.
• W4313706457 hasConcept C164705383 @default.
• W4313706457 hasConcept C207103383 @default.
• W4313706457 hasConcept C2776301958 @default.
• W4313706457 hasConcept C2778653478 @default.
• W4313706457 hasConcept C2778661090 @default.
• W4313706457 hasConcept C2778810321 @default.
• W4313706457 hasConcept C2779161974 @default.
• W4313706457 hasConcept C2779978075 @default.
• W4313706457 hasConcept C2780645631 @default.
• W4313706457 hasConcept C44249647 @default.
• W4313706457 hasConcept C71924100 @default.
• W4313706457 hasConcept C78519656 @default.
• W4313706457 hasConceptScore W4313706457C126322002 @default.
• W4313706457 hasConceptScore W4313706457C127413603 @default.
• W4313706457 hasConceptScore W4313706457C159641895 @default.
• W4313706457 hasConceptScore W4313706457C164705383 @default.
• W4313706457 hasConceptScore W4313706457C207103383 @default.
• W4313706457 hasConceptScore W4313706457C2776301958 @default.
• W4313706457 hasConceptScore W4313706457C2778653478 @default.
• W4313706457 hasConceptScore W4313706457C2778661090 @default.
• W4313706457 hasConceptScore W4313706457C2778810321 @default.
• W4313706457 hasConceptScore W4313706457C2779161974 @default.
• W4313706457 hasConceptScore W4313706457C2779978075 @default.
• W4313706457 hasConceptScore W4313706457C2780645631 @default.
• W4313706457 hasConceptScore W4313706457C44249647 @default.
• W4313706457 hasConceptScore W4313706457C71924100 @default.
• W4313706457 hasConceptScore W4313706457C78519656 @default.
• W4313706457 hasFunder F4320328598 @default.
• W4313706457 hasIssue "5" @default.
• W4313706457 hasLocation W43137064571 @default.
• W4313706457 hasLocation W43137064572 @default.
• W4313706457 hasLocation W43137064573 @default.
• W4313706457 hasOpenAccess W4313706457 @default.
• W4313706457 hasPrimaryLocation W43137064571 @default.
• W4313706457 hasRelatedWork W1982764283 @default.
• W4313706457 hasRelatedWork W1993190469 @default.
• W4313706457 hasRelatedWork W2003235938 @default.
• W4313706457 hasRelatedWork W2049310472 @default.
• W4313706457 hasRelatedWork W2509901103 @default.
• W4313706457 hasRelatedWork W2606162097 @default.
• W4313706457 hasRelatedWork W2608094018 @default.
• W4313706457 hasRelatedWork W2789710191 @default.
• W4313706457 hasRelatedWork W2896204226 @default.
• W4313706457 hasRelatedWork W4312065727 @default.
• W4313706457 hasVolume "16" @default.

• next