Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313706520> ?p ?o ?g. }
- W4313706520 abstract "Abstract Skeletal development depends on coordinated angiogenesis and osteogenesis. Bone morphogenetic proteins direct bone development by activating SMAD1/5 signaling in osteoblasts. However, the role of SMAD1/5 in skeletal endothelium is unknown. Here, we found that endothelial cell-conditional SMAD1/5 depletion in juvenile mice caused metaphyseal and diaphyseal hypervascularity, resulting in altered cancellous and cortical bone formation. SMAD1/5 depletion induced excessive sprouting, disrupting the columnar structure of the metaphyseal vessels and impaired anastomotic loop morphogenesis at the chondro-osseous junction. Endothelial SMAD1/5 depletion impaired growth plate resorption and, upon long term depletion, abrogated osteoprogenitor recruitment to the primary spongiosa. Finally, in the diaphysis, endothelial SMAD1/5 activity was necessary to maintain the sinusoidal phenotype, with SMAD1/5 depletion inducing formation of large vascular loops, featuring elevated endomucin expression, ectopic tip cell formation, and hyperpermeability. Together, endothelial SMAD1/5 activity sustains skeletal vascular morphogenesis and function and coordinates growth plate remodeling and osteoprogenitor recruitment dynamics during bone growth." @default.
- W4313706520 created "2023-01-08" @default.
- W4313706520 creator A5002172692 @default.
- W4313706520 creator A5010502376 @default.
- W4313706520 creator A5013682083 @default.
- W4313706520 creator A5018818611 @default.
- W4313706520 creator A5021680016 @default.
- W4313706520 creator A5032144064 @default.
- W4313706520 creator A5070263200 @default.
- W4313706520 creator A5073677693 @default.
- W4313706520 date "2023-01-07" @default.
- W4313706520 modified "2023-10-02" @default.
- W4313706520 title "Endothelial SMAD1/5 signaling couples angiogenesis to osteogenesis during long bone growth" @default.
- W4313706520 cites W1583699618 @default.
- W4313706520 cites W1969575246 @default.
- W4313706520 cites W1970270883 @default.
- W4313706520 cites W1971951473 @default.
- W4313706520 cites W1974550900 @default.
- W4313706520 cites W1984213135 @default.
- W4313706520 cites W1986469118 @default.
- W4313706520 cites W2019562739 @default.
- W4313706520 cites W2028062768 @default.
- W4313706520 cites W2045095867 @default.
- W4313706520 cites W2051737747 @default.
- W4313706520 cites W2054162382 @default.
- W4313706520 cites W2064386642 @default.
- W4313706520 cites W2068645866 @default.
- W4313706520 cites W2076353254 @default.
- W4313706520 cites W2087363756 @default.
- W4313706520 cites W2089254126 @default.
- W4313706520 cites W2093654042 @default.
- W4313706520 cites W2095605427 @default.
- W4313706520 cites W2102618636 @default.
- W4313706520 cites W2110555613 @default.
- W4313706520 cites W2150009829 @default.
- W4313706520 cites W2159224618 @default.
- W4313706520 cites W2160489211 @default.
- W4313706520 cites W2163504684 @default.
- W4313706520 cites W2166920557 @default.
- W4313706520 cites W2177201093 @default.
- W4313706520 cites W2261324366 @default.
- W4313706520 cites W2589465440 @default.
- W4313706520 cites W2605187236 @default.
- W4313706520 cites W2738269839 @default.
- W4313706520 cites W2773203873 @default.
- W4313706520 cites W2780806842 @default.
- W4313706520 cites W2797063763 @default.
- W4313706520 cites W2884048998 @default.
- W4313706520 cites W2884883289 @default.
- W4313706520 cites W2900408879 @default.
- W4313706520 cites W2913387229 @default.
- W4313706520 cites W2932926289 @default.
- W4313706520 cites W2969646121 @default.
- W4313706520 cites W3000473592 @default.
- W4313706520 cites W3004005451 @default.
- W4313706520 cites W3004526977 @default.
- W4313706520 cites W3012616341 @default.
- W4313706520 cites W3080537084 @default.
- W4313706520 cites W3176734525 @default.
- W4313706520 cites W4205682033 @default.
- W4313706520 cites W4239171241 @default.
- W4313706520 cites W4240373538 @default.
- W4313706520 doi "https://doi.org/10.1101/2023.01.07.522994" @default.
- W4313706520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36712097" @default.
- W4313706520 hasPublicationYear "2023" @default.
- W4313706520 type Work @default.
- W4313706520 citedByCount "0" @default.
- W4313706520 crossrefType "posted-content" @default.
- W4313706520 hasAuthorship W4313706520A5002172692 @default.
- W4313706520 hasAuthorship W4313706520A5010502376 @default.
- W4313706520 hasAuthorship W4313706520A5013682083 @default.
- W4313706520 hasAuthorship W4313706520A5018818611 @default.
- W4313706520 hasAuthorship W4313706520A5021680016 @default.
- W4313706520 hasAuthorship W4313706520A5032144064 @default.
- W4313706520 hasAuthorship W4313706520A5070263200 @default.
- W4313706520 hasAuthorship W4313706520A5073677693 @default.
- W4313706520 hasBestOaLocation W43137065201 @default.
- W4313706520 hasConcept C104317684 @default.
- W4313706520 hasConcept C123012128 @default.
- W4313706520 hasConcept C126322002 @default.
- W4313706520 hasConcept C134018914 @default.
- W4313706520 hasConcept C185592680 @default.
- W4313706520 hasConcept C201750760 @default.
- W4313706520 hasConcept C202751555 @default.
- W4313706520 hasConcept C2778260815 @default.
- W4313706520 hasConcept C2778271429 @default.
- W4313706520 hasConcept C2780394083 @default.
- W4313706520 hasConcept C28328180 @default.
- W4313706520 hasConcept C2910429298 @default.
- W4313706520 hasConcept C31507581 @default.
- W4313706520 hasConcept C40692019 @default.
- W4313706520 hasConcept C55493867 @default.
- W4313706520 hasConcept C60781801 @default.
- W4313706520 hasConcept C673006 @default.
- W4313706520 hasConcept C71924100 @default.
- W4313706520 hasConcept C86803240 @default.
- W4313706520 hasConcept C95444343 @default.
- W4313706520 hasConceptScore W4313706520C104317684 @default.
- W4313706520 hasConceptScore W4313706520C123012128 @default.
- W4313706520 hasConceptScore W4313706520C126322002 @default.