Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313706717> ?p ?o ?g. }
- W4313706717 abstract "Despite the rapid utilization of immunotherapy, emerging challenges to the current immune checkpoint blockade need to be resolved. Here, we report that elevation of CD73 levels due to its aberrant turnover is correlated with poor prognosis in immune-cold triple-negative breast cancers (TNBCs). We have identified TRIM21 as an E3 ligase that governs CD73 destruction. Disruption of TRIM21 stabilizes CD73 that in turn enhances CD73-catalyzed production of adenosine, resulting in the suppression of CD8+ T cell function. Replacement of lysine 133, 208, 262, and 321 residues by arginine on CD73 attenuated CD73 ubiquitylation and degradation. Diminishing of CD73 ubiquitylation remarkably promotes tumor growth and impedes antitumor immunity. In addition, a TRIM21high/CD73low signature in a subgroup of human breast malignancies was associated with a favorable immune profile. Collectively, our findings uncover a mechanism that governs CD73 proteolysis and point to a new therapeutic strategy by modulating CD73 ubiquitylation." @default.
- W4313706717 created "2023-01-08" @default.
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- W4313706717 creator A5090385327 @default.
- W4313706717 date "2023-01-06" @default.
- W4313706717 modified "2023-10-09" @default.
- W4313706717 title "Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity" @default.
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- W4313706717 doi "https://doi.org/10.1126/sciadv.add6626" @default.
- W4313706717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36608132" @default.
- W4313706717 hasPublicationYear "2023" @default.