Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313706731> ?p ?o ?g. }
- W4313706731 abstract "Atopic dermatitis (AD) is a chronic inflammatory skin condition increasing in industrial nations at a pace that suggests environmental drivers. We hypothesize that the dysbiosis associated with AD may signal microbial adaptations to modern pollutants. Having previously modeled the benefits of health-associated Roseomonas mucosa , we now show that R. mucosa fixes nitrogen in the production of protective glycerolipids and their ceramide by-products. Screening EPA databases against the clinical visit rates identified diisocyanates as the strongest predictor of AD. Diisocyanates disrupted the production of beneficial lipids and therapeutic modeling for isolates of R. mucosa as well as commensal Staphylococcus . Last, while topical R. mucosa failed to meet commercial end points in a placebo-controlled trial, the subgroup who completed the full protocol demonstrated sustained, clinically modest, but statistically significant clinical improvements that differed by study site diisocyanate levels. Therefore, diisocyanates show temporospatial and epidemiological association with AD while also inducing eczematous dysbiosis." @default.
- W4313706731 created "2023-01-08" @default.
- W4313706731 creator A5015905197 @default.
- W4313706731 creator A5017261720 @default.
- W4313706731 creator A5026397714 @default.
- W4313706731 creator A5031029980 @default.
- W4313706731 creator A5034761113 @default.
- W4313706731 creator A5043154979 @default.
- W4313706731 creator A5049710821 @default.
- W4313706731 creator A5050341062 @default.
- W4313706731 creator A5053009541 @default.
- W4313706731 creator A5071480547 @default.
- W4313706731 creator A5071907436 @default.
- W4313706731 creator A5072290776 @default.
- W4313706731 creator A5085809688 @default.
- W4313706731 creator A5089094479 @default.
- W4313706731 date "2023-01-06" @default.
- W4313706731 modified "2023-09-26" @default.
- W4313706731 title "Exposure to isocyanates predicts atopic dermatitis prevalence and disrupts therapeutic pathways in commensal bacteria" @default.
- W4313706731 cites W1527957830 @default.
- W4313706731 cites W1917670147 @default.
- W4313706731 cites W1971402668 @default.
- W4313706731 cites W2010188725 @default.
- W4313706731 cites W2055599111 @default.
- W4313706731 cites W2056399136 @default.
- W4313706731 cites W2069111893 @default.
- W4313706731 cites W2069984049 @default.
- W4313706731 cites W2070918755 @default.
- W4313706731 cites W2089853915 @default.
- W4313706731 cites W2092640983 @default.
- W4313706731 cites W2097360283 @default.
- W4313706731 cites W2097671337 @default.
- W4313706731 cites W2102394193 @default.
- W4313706731 cites W2111664831 @default.
- W4313706731 cites W2117733468 @default.
- W4313706731 cites W2126968881 @default.
- W4313706731 cites W2139644553 @default.
- W4313706731 cites W2140845434 @default.
- W4313706731 cites W2141316016 @default.
- W4313706731 cites W2163216482 @default.
- W4313706731 cites W2177756355 @default.
- W4313706731 cites W2267335000 @default.
- W4313706731 cites W2319024568 @default.
- W4313706731 cites W2328695691 @default.
- W4313706731 cites W2335909841 @default.
- W4313706731 cites W2346021341 @default.
- W4313706731 cites W2466082513 @default.
- W4313706731 cites W2466443795 @default.
- W4313706731 cites W2469218097 @default.
- W4313706731 cites W2490471244 @default.
- W4313706731 cites W2568439581 @default.
- W4313706731 cites W2741334054 @default.
- W4313706731 cites W2750417371 @default.
- W4313706731 cites W2756050581 @default.
- W4313706731 cites W2771749011 @default.
- W4313706731 cites W2786693279 @default.
- W4313706731 cites W2800473251 @default.
- W4313706731 cites W2807276509 @default.
- W4313706731 cites W2883330640 @default.
- W4313706731 cites W2889501685 @default.
- W4313706731 cites W2900884128 @default.
- W4313706731 cites W2900930366 @default.
- W4313706731 cites W2901405880 @default.
- W4313706731 cites W2909011098 @default.
- W4313706731 cites W2924671725 @default.
- W4313706731 cites W2982151297 @default.
- W4313706731 cites W2995784855 @default.
- W4313706731 cites W3033652264 @default.
- W4313706731 cites W3038938742 @default.
- W4313706731 cites W3046970802 @default.
- W4313706731 cites W3084257556 @default.
- W4313706731 cites W3096705824 @default.
- W4313706731 cites W3102027041 @default.
- W4313706731 cites W3112768169 @default.
- W4313706731 cites W3125398380 @default.
- W4313706731 cites W3129601032 @default.
- W4313706731 cites W3155248034 @default.
- W4313706731 cites W3157212212 @default.
- W4313706731 cites W3159727624 @default.
- W4313706731 cites W3162413844 @default.
- W4313706731 cites W3197450259 @default.
- W4313706731 cites W3205632507 @default.
- W4313706731 cites W4200445623 @default.
- W4313706731 cites W4210719890 @default.
- W4313706731 cites W4226019796 @default.
- W4313706731 cites W4294541781 @default.
- W4313706731 cites W4298833692 @default.
- W4313706731 cites W4302569409 @default.
- W4313706731 doi "https://doi.org/10.1126/sciadv.ade8898" @default.
- W4313706731 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36608129" @default.
- W4313706731 hasPublicationYear "2023" @default.
- W4313706731 type Work @default.
- W4313706731 citedByCount "5" @default.
- W4313706731 countsByYear W43137067312023 @default.
- W4313706731 crossrefType "journal-article" @default.
- W4313706731 hasAuthorship W4313706731A5015905197 @default.
- W4313706731 hasAuthorship W4313706731A5017261720 @default.
- W4313706731 hasAuthorship W4313706731A5026397714 @default.
- W4313706731 hasAuthorship W4313706731A5031029980 @default.
- W4313706731 hasAuthorship W4313706731A5034761113 @default.