Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313706746> ?p ?o ?g. }
- W4313706746 abstract "The maturation of HIV-1 capsid protein (CA) into a cone-shaped lattice capsid is critical for viral infectivity. CA can self-assemble into a range of capsid morphologies made of ~175 to 250 hexamers and 12 pentamers. The cellular polyanion inositol hexakisphosphate (IP6) has recently been demonstrated to facilitate conical capsid formation by coordinating a ring of arginine residues within the central cavity of capsid hexamers and pentamers. However, the kinetic interplay of events during IP6 and CA coassembly is unclear. In this work, we use coarse-grained molecular dynamics simulations to elucidate the molecular mechanism of capsid formation, including the role played by IP6. We show that IP6, in small quantities at first, promotes curvature generation by trapping pentameric defects in the growing lattice and shifts assembly behavior toward kinetically favored outcomes. Our analysis also suggests that IP6 can stabilize metastable capsid intermediates and can induce structural pleomorphism in mature capsids." @default.
- W4313706746 created "2023-01-08" @default.
- W4313706746 creator A5001612107 @default.
- W4313706746 creator A5004172217 @default.
- W4313706746 creator A5075789940 @default.
- W4313706746 date "2023-01-06" @default.
- W4313706746 modified "2023-10-12" @default.
- W4313706746 title "Critical mechanistic features of HIV-1 viral capsid assembly" @default.
- W4313706746 cites W1523228641 @default.
- W4313706746 cites W1599129674 @default.
- W4313706746 cites W1611298747 @default.
- W4313706746 cites W1816747902 @default.
- W4313706746 cites W1823429634 @default.
- W4313706746 cites W1964022123 @default.
- W4313706746 cites W1984806569 @default.
- W4313706746 cites W2000218608 @default.
- W4313706746 cites W2003527687 @default.
- W4313706746 cites W2007695240 @default.
- W4313706746 cites W2011301426 @default.
- W4313706746 cites W2017686863 @default.
- W4313706746 cites W2019465613 @default.
- W4313706746 cites W2021064626 @default.
- W4313706746 cites W2027300565 @default.
- W4313706746 cites W2029667189 @default.
- W4313706746 cites W2033236966 @default.
- W4313706746 cites W2041321679 @default.
- W4313706746 cites W2042649563 @default.
- W4313706746 cites W2042941075 @default.
- W4313706746 cites W2043701535 @default.
- W4313706746 cites W2052076314 @default.
- W4313706746 cites W2056066950 @default.
- W4313706746 cites W2060174126 @default.
- W4313706746 cites W2061714407 @default.
- W4313706746 cites W2067530227 @default.
- W4313706746 cites W2076965602 @default.
- W4313706746 cites W2078109757 @default.
- W4313706746 cites W2078205352 @default.
- W4313706746 cites W2084131702 @default.
- W4313706746 cites W2093904805 @default.
- W4313706746 cites W2094692623 @default.
- W4313706746 cites W2107120241 @default.
- W4313706746 cites W2115851369 @default.
- W4313706746 cites W2117091532 @default.
- W4313706746 cites W2117867057 @default.
- W4313706746 cites W2125779634 @default.
- W4313706746 cites W2126480371 @default.
- W4313706746 cites W2128286418 @default.
- W4313706746 cites W2133121775 @default.
- W4313706746 cites W2135035609 @default.
- W4313706746 cites W2145652748 @default.
- W4313706746 cites W2156696460 @default.
- W4313706746 cites W2168482038 @default.
- W4313706746 cites W2289084400 @default.
- W4313706746 cites W2324183217 @default.
- W4313706746 cites W2517950264 @default.
- W4313706746 cites W2562928209 @default.
- W4313706746 cites W2565695020 @default.
- W4313706746 cites W2738606079 @default.
- W4313706746 cites W2886259097 @default.
- W4313706746 cites W2901238527 @default.
- W4313706746 cites W2902461580 @default.
- W4313706746 cites W2950776490 @default.
- W4313706746 cites W2951605984 @default.
- W4313706746 cites W2992616830 @default.
- W4313706746 cites W2994798248 @default.
- W4313706746 cites W3043992826 @default.
- W4313706746 cites W3046892973 @default.
- W4313706746 cites W3084482432 @default.
- W4313706746 cites W3134041051 @default.
- W4313706746 cites W3139728913 @default.
- W4313706746 cites W3188249522 @default.
- W4313706746 cites W4214938859 @default.
- W4313706746 doi "https://doi.org/10.1126/sciadv.add7434" @default.
- W4313706746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36608139" @default.
- W4313706746 hasPublicationYear "2023" @default.
- W4313706746 type Work @default.
- W4313706746 citedByCount "10" @default.
- W4313706746 countsByYear W43137067462023 @default.
- W4313706746 crossrefType "journal-article" @default.
- W4313706746 hasAuthorship W4313706746A5001612107 @default.
- W4313706746 hasAuthorship W4313706746A5004172217 @default.
- W4313706746 hasAuthorship W4313706746A5075789940 @default.
- W4313706746 hasBestOaLocation W43137067461 @default.
- W4313706746 hasConcept C12554922 @default.
- W4313706746 hasConcept C147597530 @default.
- W4313706746 hasConcept C159047783 @default.
- W4313706746 hasConcept C185592680 @default.
- W4313706746 hasConcept C202878990 @default.
- W4313706746 hasConcept C2522874641 @default.
- W4313706746 hasConcept C59593255 @default.
- W4313706746 hasConcept C6235761 @default.
- W4313706746 hasConcept C8010536 @default.
- W4313706746 hasConcept C86803240 @default.
- W4313706746 hasConcept C95444343 @default.
- W4313706746 hasConceptScore W4313706746C12554922 @default.
- W4313706746 hasConceptScore W4313706746C147597530 @default.
- W4313706746 hasConceptScore W4313706746C159047783 @default.
- W4313706746 hasConceptScore W4313706746C185592680 @default.
- W4313706746 hasConceptScore W4313706746C202878990 @default.
- W4313706746 hasConceptScore W4313706746C2522874641 @default.