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- W4313706848 endingPage "117157" @default.
- W4313706848 startingPage "117157" @default.
- W4313706848 abstract "Natural products continue to be an inspiration for new drugs to treat debilitating diseases such as cancer. Usnic acid is a secondary metabolite isolated predominately from lichen species and has been shown to exhibit antiproliferative properties, however its application is limited by poor drug-like properties and low specificity. We report our work on investigating the reactivity of usnic acid for incorporating heterocyclic rings and the divergent reactivity that can be obtained by simply altering the reaction solvent and temperature. The synthesised derivatives were then tested against HeLa cancer cells for their antiproliferative properties. A number of promising compounds were obtained including 4, 5 and 9 that showed an IC50 of 878, 311 and 116 nM, respectively, against HeLa cancer cells after 48 h of treatment." @default.
- W4313706848 created "2023-01-08" @default.
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- W4313706848 date "2023-02-01" @default.
- W4313706848 modified "2023-10-01" @default.
- W4313706848 title "Divergent reactivity of usnic acid and evaluation of its derivatives for antiproliferative activity against cancer cells" @default.
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- W4313706848 doi "https://doi.org/10.1016/j.bmc.2023.117157" @default.
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