FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313706903> ?p ?o ?g. }

• W4313706903 endingPage "116149" @default.
• W4313706903 startingPage "116149" @default.
• W4313706903 abstract "Atopic dermatitis (AD) is a common chronic inflammatory skin disorder and its prevalence is increasing in the last few decades. No treatment can cure the condition. Pregnancy often worsens the clinical manifestation. There are considerable interests in Chinese Herbal Medicine (CHM) as an alternative treatment for AD. A well tolerated CHM formula (Pentaherbs formulation, PHF) has been proven efficacious in improving life quality and reducing topical corticosteroid use in children with moderate-to-severe AD. However, safety data of PHF are not available. Our study aimed to evaluate the safety of PHF and its 5 individual herbal extracts, including embryotoxicity by Embryonic Stem Cell Test (EST) and irritation by Skin Irritation Test (SIT). Quality of 5 herbal extracts of PHF was confirmed by chromatography. In EST, mouse embryonic stem cell line (D3) and mouse fibroblast cell line (3T3) were used to study potential embryotoxicity. Three endpoints were assessed by concentration-response curves after 10 days’ culture: 50% inhibition of D3 differentiation into beating cardiomyocytes (ID50D3), 50% cytotoxic effects on D3 (IC50D3) and on fibroblasts (IC503T3). A biostatistically based prediction model (PM) was applied to predict the embryotoxic potentials of each CHM. In SIT, epidermis equivalent commercially available kits (EpiDerm™) were used, and concentration-viability curves were obtained by MTT assay to detect skin irritations of each CHM. Chemical authentication confirmed that 5 test herbal extracts contained their main active compounds. EST results indicated that the formula PHF and its individual CHMs were non-embryotoxic, except one CHM, Amur Corktree Bark (Huang Bai, Phellodendron chinense C.K.Schneid), was weakly embryotoxic. SIT results showed that cell viability was above 50% after treatment with different concentrations of all tested CHMs. Our in vitro tests provided preliminary evidence for safety of the formula PHF in embryonic stem cell test and skin irritation model, but PHF shall be cautiously used in pregnant women with AD. Further studies are needed to support its clinical application as an alternative treatment for AD, especially to the patients who plan for pregnancy or at lactation stages." @default.
• W4313706903 created "2023-01-08" @default.
• W4313706903 creator A5018202083 @default.
• W4313706903 creator A5030817752 @default.
• W4313706903 creator A5030866369 @default.
• W4313706903 creator A5035224742 @default.
• W4313706903 creator A5036847453 @default.
• W4313706903 creator A5043019475 @default.
• W4313706903 creator A5050487837 @default.
• W4313706903 creator A5058499967 @default.
• W4313706903 creator A5060364374 @default.
• W4313706903 creator A5071442140 @default.
• W4313706903 creator A5079990086 @default.
• W4313706903 creator A5083833865 @default.
• W4313706903 creator A5089304765 @default.
• W4313706903 date "2023-04-01" @default.
• W4313706903 modified "2023-10-15" @default.
• W4313706903 title "In vitro tests to evaluate embryotoxicity and irritation of Chinese herbal medicine (Pentaherbs formulation) for atopic dermatitis" @default.
• W4313706903 cites W1499596553 @default.
• W4313706903 cites W189068515 @default.
• W4313706903 cites W1948938001 @default.
• W4313706903 cites W1966578037 @default.
• W4313706903 cites W1986813124 @default.
• W4313706903 cites W1994823788 @default.
• W4313706903 cites W1996609353 @default.
• W4313706903 cites W1999763200 @default.
• W4313706903 cites W2008251101 @default.
• W4313706903 cites W2010525321 @default.
• W4313706903 cites W2019264005 @default.
• W4313706903 cites W2038864459 @default.
• W4313706903 cites W2064636970 @default.
• W4313706903 cites W2086484740 @default.
• W4313706903 cites W2089709635 @default.
• W4313706903 cites W2090860096 @default.
• W4313706903 cites W2101998524 @default.
• W4313706903 cites W2105317528 @default.
• W4313706903 cites W2123308898 @default.
• W4313706903 cites W2170622744 @default.
• W4313706903 cites W2338183893 @default.
• W4313706903 cites W2729916652 @default.
• W4313706903 cites W2755564973 @default.
• W4313706903 cites W2765116917 @default.
• W4313706903 cites W2952410573 @default.
• W4313706903 cites W3045644757 @default.
• W4313706903 cites W4211026773 @default.
• W4313706903 cites W4280521049 @default.
• W4313706903 doi "https://doi.org/10.1016/j.jep.2023.116149" @default.
• W4313706903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36632857" @default.
• W4313706903 hasPublicationYear "2023" @default.
• W4313706903 type Work @default.
• W4313706903 citedByCount "1" @default.
• W4313706903 countsByYear W43137069032023 @default.
• W4313706903 crossrefType "journal-article" @default.
• W4313706903 hasAuthorship W4313706903A5018202083 @default.
• W4313706903 hasAuthorship W4313706903A5030817752 @default.
• W4313706903 hasAuthorship W4313706903A5030866369 @default.
• W4313706903 hasAuthorship W4313706903A5035224742 @default.
• W4313706903 hasAuthorship W4313706903A5036847453 @default.
• W4313706903 hasAuthorship W4313706903A5043019475 @default.
• W4313706903 hasAuthorship W4313706903A5050487837 @default.
• W4313706903 hasAuthorship W4313706903A5058499967 @default.
• W4313706903 hasAuthorship W4313706903A5060364374 @default.
• W4313706903 hasAuthorship W4313706903A5071442140 @default.
• W4313706903 hasAuthorship W4313706903A5079990086 @default.
• W4313706903 hasAuthorship W4313706903A5083833865 @default.
• W4313706903 hasAuthorship W4313706903A5089304765 @default.
• W4313706903 hasBestOaLocation W43137069031 @default.
• W4313706903 hasConcept C142724271 @default.
• W4313706903 hasConcept C16005928 @default.
• W4313706903 hasConcept C188947578 @default.
• W4313706903 hasConcept C203014093 @default.
• W4313706903 hasConcept C204787440 @default.
• W4313706903 hasConcept C2777063393 @default.
• W4313706903 hasConcept C2778329239 @default.
• W4313706903 hasConcept C53227056 @default.
• W4313706903 hasConcept C54355233 @default.
• W4313706903 hasConcept C556039675 @default.
• W4313706903 hasConcept C71924100 @default.
• W4313706903 hasConcept C81885089 @default.
• W4313706903 hasConcept C86803240 @default.
• W4313706903 hasConcept C98274493 @default.
• W4313706903 hasConceptScore W4313706903C142724271 @default.
• W4313706903 hasConceptScore W4313706903C16005928 @default.
• W4313706903 hasConceptScore W4313706903C188947578 @default.
• W4313706903 hasConceptScore W4313706903C203014093 @default.
• W4313706903 hasConceptScore W4313706903C204787440 @default.
• W4313706903 hasConceptScore W4313706903C2777063393 @default.
• W4313706903 hasConceptScore W4313706903C2778329239 @default.
• W4313706903 hasConceptScore W4313706903C53227056 @default.
• W4313706903 hasConceptScore W4313706903C54355233 @default.
• W4313706903 hasConceptScore W4313706903C556039675 @default.
• W4313706903 hasConceptScore W4313706903C71924100 @default.
• W4313706903 hasConceptScore W4313706903C81885089 @default.
• W4313706903 hasConceptScore W4313706903C86803240 @default.
• W4313706903 hasConceptScore W4313706903C98274493 @default.
• W4313706903 hasLocation W43137069031 @default.
• W4313706903 hasLocation W43137069032 @default.
• W4313706903 hasOpenAccess W4313706903 @default.

• next