FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313730595> ?p ?o ?g. }

• W4313730595 endingPage "1213" @default.
• W4313730595 startingPage "1200" @default.
• W4313730595 abstract "Background Titanium (Ti) and its alloys are widely used in manufacturing medical devices because of their strength and resistance to corrosion. Although Ti compounds are considered compatible with blood, they appear to support plasma contact activation and may be thrombogenic. Objectives The objective of this study was to compare Ti and titanium nitride (TiN) with known activators of contact activation (kaolin and silica) in plasma-clotting assays and to assess binding and activation of factor XII, (FXII), factor XI (FXI), prekallikrein, and high-molecular-weight kininogen (HK) with Ti/TiN. Methods Ti-based nanospheres and foils were compared with kaolin, silica, and aluminum in plasma-clotting assays. Binding and activation of FXII, prekallikrein, HK, and FXI to surfaces was assessed with western blots and chromogenic assays. Results Using equivalent surface amounts, Ti and TiN were comparable with kaolin and superior to silica, for inducing coagulation and FXII autoactivation. Similar to many inducers of contact activation, Ti and TiN are negatively charged; however, their effects on FXII are not neutralized by the polycation polybrene. Antibodies to FXII, prekallikrein, or FXI or coating Ti with poly-L-arginine blocked Ti-induced coagulation. An antibody to FXII reduced FXII and PK binding to Ti, kallikrein generation, and HK cleavage. Conclusion Titanium compounds induce contact activation with a potency comparable with that of kaolin. Binding of FXII with Ti shares some features with FXII binding to soluble polyanions but may have unique features. Inhibitors targeting FXII or FXI may be useful in mitigating Ti-induced contact activation in patients with titanium-based implants that are exposed to blood." @default.
• W4313730595 created "2023-01-08" @default.
• W4313730595 creator A5011450008 @default.
• W4313730595 creator A5021496734 @default.
• W4313730595 creator A5026005041 @default.
• W4313730595 creator A5040299351 @default.
• W4313730595 creator A5050978437 @default.
• W4313730595 creator A5060358952 @default.
• W4313730595 creator A5065711672 @default.
• W4313730595 creator A5065833581 @default.
• W4313730595 creator A5082462527 @default.
• W4313730595 creator A5085860682 @default.
• W4313730595 date "2023-05-01" @default.
• W4313730595 modified "2023-10-04" @default.
• W4313730595 title "Titanium is a potent inducer of contact activation: implications for intravascular devices" @default.
• W4313730595 cites W1514319676 @default.
• W4313730595 cites W1552364292 @default.
• W4313730595 cites W1580875494 @default.
• W4313730595 cites W1599568592 @default.
• W4313730595 cites W1942082199 @default.
• W4313730595 cites W1949206000 @default.
• W4313730595 cites W1970158391 @default.
• W4313730595 cites W1973582303 @default.
• W4313730595 cites W1979226129 @default.
• W4313730595 cites W1986053269 @default.
• W4313730595 cites W1990240889 @default.
• W4313730595 cites W1994284977 @default.
• W4313730595 cites W1996136104 @default.
• W4313730595 cites W1998399069 @default.
• W4313730595 cites W2001420755 @default.
• W4313730595 cites W2001888395 @default.
• W4313730595 cites W2024620036 @default.
• W4313730595 cites W2030418584 @default.
• W4313730595 cites W2030775459 @default.
• W4313730595 cites W2049351715 @default.
• W4313730595 cites W2051955545 @default.
• W4313730595 cites W2058098574 @default.
• W4313730595 cites W2060021951 @default.
• W4313730595 cites W2063706685 @default.
• W4313730595 cites W2065856044 @default.
• W4313730595 cites W2072701411 @default.
• W4313730595 cites W2078094108 @default.
• W4313730595 cites W2081296960 @default.
• W4313730595 cites W2083264522 @default.
• W4313730595 cites W2083884362 @default.
• W4313730595 cites W2092025164 @default.
• W4313730595 cites W2099127967 @default.
• W4313730595 cites W2102719739 @default.
• W4313730595 cites W2109339951 @default.
• W4313730595 cites W2117944864 @default.
• W4313730595 cites W2177124431 @default.
• W4313730595 cites W2201309601 @default.
• W4313730595 cites W2338854794 @default.
• W4313730595 cites W2346698849 @default.
• W4313730595 cites W2346766681 @default.
• W4313730595 cites W2395468092 @default.
• W4313730595 cites W2488932622 @default.
• W4313730595 cites W2497397127 @default.
• W4313730595 cites W2569964808 @default.
• W4313730595 cites W2590412695 @default.
• W4313730595 cites W2603384895 @default.
• W4313730595 cites W2763549184 @default.
• W4313730595 cites W2806482113 @default.
• W4313730595 cites W2895059150 @default.
• W4313730595 cites W2912137362 @default.
• W4313730595 cites W2914583666 @default.
• W4313730595 cites W2922229775 @default.
• W4313730595 cites W2944736303 @default.
• W4313730595 cites W2958674338 @default.
• W4313730595 cites W2998912706 @default.
• W4313730595 cites W2999873990 @default.
• W4313730595 cites W3005620645 @default.
• W4313730595 cites W3026567617 @default.
• W4313730595 cites W3034241874 @default.
• W4313730595 cites W3092860697 @default.
• W4313730595 cites W3111429272 @default.
• W4313730595 cites W3121751223 @default.
• W4313730595 cites W3164883358 @default.
• W4313730595 cites W3183350800 @default.
• W4313730595 cites W3186384071 @default.
• W4313730595 cites W3200309890 @default.
• W4313730595 cites W3205489651 @default.
• W4313730595 cites W3210228149 @default.
• W4313730595 cites W3212517452 @default.
• W4313730595 cites W4200427606 @default.
• W4313730595 cites W4210750342 @default.
• W4313730595 cites W4210756016 @default.
• W4313730595 cites W4214686760 @default.
• W4313730595 cites W4221057065 @default.
• W4313730595 cites W4289450219 @default.
• W4313730595 cites W4297874879 @default.
• W4313730595 cites W88104821 @default.
• W4313730595 doi "https://doi.org/10.1016/j.jtha.2022.12.014" @default.
• W4313730595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36696212" @default.
• W4313730595 hasPublicationYear "2023" @default.
• W4313730595 type Work @default.
• W4313730595 citedByCount "5" @default.
• W4313730595 countsByYear W43137305952023 @default.

• next