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- W4313813090 abstract "Abstract Somatic mutations in tumors can generate neoantigens that are presented on the cell surface through MHC molecules. As these mutations are expected to be unique to each tumor and as these generated (and presented) neoantigens play a significant role in mediating immune response against the tumor through tumor-specific T-cells, personalized cancer immunotherapy for each tumor can be designed, formed, and effective in curing cancer. MHC class I pathway consists of four main steps: proteasomal cleavage in the cytosol in which proteins are cleaved into smaller peptides, precursors are then transported into the endoplasmic reticulum by the transporter associated with antigen processing (TAP), next further processing (trimming) at the N-terminal region is undertaken by an ER resident aminopeptidases 1 (ERAP1) enzyme to generate optimal lengths (8-10 amino acids) to produce a stable MHCI: peptide association, and finally the trimmed precursors are loaded into MHCI molecule to be transited via the Golgi apparatus to the cell surface for presentation to the cellualar immune system. Several studies reported specificities related to the ERAP1 trimming process and yet there is no in silico tool for the prediction of the trimming process of the ERAP1 enzyme. In this paper, we provide and implement a prediction model for the trimming process of the ERAP1 enzyme." @default.
- W4313813090 created "2023-01-09" @default.
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- W4313813090 date "2023-01-09" @default.
- W4313813090 modified "2023-10-17" @default.
- W4313813090 title "ERAMER: A Novel In silico Tool for Prediction of ERAP1 Enzyme Trimming" @default.
- W4313813090 doi "https://doi.org/10.21203/rs.3.rs-2426010/v1" @default.
- W4313813090 hasPublicationYear "2023" @default.
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