FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313824118> ?p ?o ?g. }

• W4313824118 abstract "Abdominal aortic aneurysm (AAA) is a life-threatening disease and there is currently a lack of effective treatment to prevent it rupturing. ScRNA-seq studies of AAA are still lacking. In the study, we analyzed the published AAA scRNA-seq datasets from the mouse elastase-induced model, CaCl 2 treatment model, Ang II-induced model and human by using bioinformatic approaches and in silico analysis. A total of 26 cell clusters were obtained and 11 cell types were identified from multiple mouse AAA models. Also, the proportion of Mφ/Mo increased in the AAA group and Mφ/Mo was divided into seven subtypes. There were significant differences in transcriptional regulation patterns of Mφ/Mo in different AAA models. The enrichment pathways of upregulated or downregulated genes from Mφ/Mo in the three mouse datasets were different. The actived regulons of Mφ/Mo had strong specificity and the repressed regulons showed high consistency. The co-upregulated genes as well as actived regulons and co-downregulated genes as well as repressed regulons were closely correlated and formed regulatory networks. Mφ/Mo from human AAA dataset was divided into five subtypes. The proportion of three macrophage subpopulations increased but the proportion of two monocyte subpopulations decreased. In the AAA group, the upregulated or downregulated genes of Mφ/Mo were enriched in different pathways. After further analyzing the genes in Mφ/Mo of both mouse and human scRNA-seq datasets, two genes were upregulated in the four datasets, IL-1B and THBS1 . In conclusion, in silico analysis of scRNA-seq revealed that Mφ/Mo and their regulatory related genes as well as interaction networks played an important role in the pathogenesis of AAA." @default.
• W4313824118 created "2023-01-09" @default.
• W4313824118 creator A5015872707 @default.
• W4313824118 creator A5025555679 @default.
• W4313824118 creator A5029673267 @default.
• W4313824118 creator A5061433331 @default.
• W4313824118 creator A5082582585 @default.
• W4313824118 creator A5083332029 @default.
• W4313824118 creator A5084808312 @default.
• W4313824118 creator A5087592842 @default.
• W4313824118 date "2023-01-09" @default.
• W4313824118 modified "2023-09-27" @default.
• W4313824118 title "Single-cell transcriptome in silico analysis reveals conserved regulatory programs in macrophages/monocytes of abdominal aortic aneurysm from multiple mouse models and human" @default.
• W4313824118 cites W2027847170 @default.
• W4313824118 cites W2059317123 @default.
• W4313824118 cites W2289708476 @default.
• W4313824118 cites W2508322647 @default.
• W4313824118 cites W2606821969 @default.
• W4313824118 cites W2616922646 @default.
• W4313824118 cites W2771207196 @default.
• W4313824118 cites W2792855672 @default.
• W4313824118 cites W2794480084 @default.
• W4313824118 cites W2803194497 @default.
• W4313824118 cites W2806830338 @default.
• W4313824118 cites W2891434859 @default.
• W4313824118 cites W2898549090 @default.
• W4313824118 cites W2900698806 @default.
• W4313824118 cites W2912699338 @default.
• W4313824118 cites W2926458547 @default.
• W4313824118 cites W2947524951 @default.
• W4313824118 cites W2959112578 @default.
• W4313824118 cites W2972604213 @default.
• W4313824118 cites W2983258725 @default.
• W4313824118 cites W3008229330 @default.
• W4313824118 cites W3026876979 @default.
• W4313824118 cites W3041541923 @default.
• W4313824118 cites W3043316039 @default.
• W4313824118 cites W3080357088 @default.
• W4313824118 cites W3125836040 @default.
• W4313824118 cites W3135995254 @default.
• W4313824118 cites W3151923718 @default.
• W4313824118 cites W3177197876 @default.
• W4313824118 cites W3206001841 @default.
• W4313824118 cites W3212099445 @default.
• W4313824118 cites W4210790098 @default.
• W4313824118 cites W4210984075 @default.
• W4313824118 cites W4213050016 @default.
• W4313824118 cites W4214869485 @default.
• W4313824118 cites W4220720432 @default.
• W4313824118 cites W4224943355 @default.
• W4313824118 cites W4225960012 @default.
• W4313824118 cites W4281780870 @default.
• W4313824118 doi "https://doi.org/10.3389/fcvm.2022.1062106" @default.
• W4313824118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36698942" @default.
• W4313824118 hasPublicationYear "2023" @default.
• W4313824118 type Work @default.
• W4313824118 citedByCount "0" @default.
• W4313824118 crossrefType "journal-article" @default.
• W4313824118 hasAuthorship W4313824118A5015872707 @default.
• W4313824118 hasAuthorship W4313824118A5025555679 @default.
• W4313824118 hasAuthorship W4313824118A5029673267 @default.
• W4313824118 hasAuthorship W4313824118A5061433331 @default.
• W4313824118 hasAuthorship W4313824118A5082582585 @default.
• W4313824118 hasAuthorship W4313824118A5083332029 @default.
• W4313824118 hasAuthorship W4313824118A5084808312 @default.
• W4313824118 hasAuthorship W4313824118A5087592842 @default.
• W4313824118 hasBestOaLocation W43138241181 @default.
• W4313824118 hasConcept C104317684 @default.
• W4313824118 hasConcept C127561419 @default.
• W4313824118 hasConcept C1491633281 @default.
• W4313824118 hasConcept C150194340 @default.
• W4313824118 hasConcept C162317418 @default.
• W4313824118 hasConcept C2775905019 @default.
• W4313824118 hasConcept C54355233 @default.
• W4313824118 hasConcept C62361671 @default.
• W4313824118 hasConcept C70721500 @default.
• W4313824118 hasConcept C86803240 @default.
• W4313824118 hasConceptScore W4313824118C104317684 @default.
• W4313824118 hasConceptScore W4313824118C127561419 @default.
• W4313824118 hasConceptScore W4313824118C1491633281 @default.
• W4313824118 hasConceptScore W4313824118C150194340 @default.
• W4313824118 hasConceptScore W4313824118C162317418 @default.
• W4313824118 hasConceptScore W4313824118C2775905019 @default.
• W4313824118 hasConceptScore W4313824118C54355233 @default.
• W4313824118 hasConceptScore W4313824118C62361671 @default.
• W4313824118 hasConceptScore W4313824118C70721500 @default.
• W4313824118 hasConceptScore W4313824118C86803240 @default.
• W4313824118 hasLocation W43138241181 @default.
• W4313824118 hasLocation W43138241182 @default.
• W4313824118 hasLocation W43138241183 @default.
• W4313824118 hasOpenAccess W4313824118 @default.
• W4313824118 hasPrimaryLocation W43138241181 @default.
• W4313824118 hasRelatedWork W1940806326 @default.
• W4313824118 hasRelatedWork W2150743143 @default.
• W4313824118 hasRelatedWork W2170298003 @default.
• W4313824118 hasRelatedWork W2529059658 @default.
• W4313824118 hasRelatedWork W2919381586 @default.
• W4313824118 hasRelatedWork W2999045264 @default.
• W4313824118 hasRelatedWork W3000738194 @default.
• W4313824118 hasRelatedWork W3029675073 @default.

• next