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- W4313826029 abstract "Parkinson's disease (PD) is the second most common neurodegenerative disease characterized by progressive loss of dopaminergic neurons in the substantia nigra of the midbrain. The etiology of PD has yet to be elucidated, and the disease remains incurable. Increasing evidence suggests that oxidative stress is the key causative factor of PD. Due to their capacity to alleviate oxidative stress, antioxidants hold great potential for the treatment of PD. Vitamins are essential organic substances for maintaining the life of organisms. Vitamin deficiency is implicated in the pathogenesis of various diseases, such as PD. In the present study, we investigated whether administration of vitamin B12 (VB12) could ameliorate PD phenotypes in vitro and in vivo. Our results showed that VB12 significantly reduced the generation of reactive oxygen species (ROS) in the rotenone-induced SH-SY5Y cellular PD model. In a Parkin gene knockout C. elegans PD model, VB12 mitigated motor dysfunction. Moreover, in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse PD model, VB12 also displayed protective effects, including the rescue of mitochondrial function, dopaminergic neuron loss, and movement disorder. In summary, our results suggest that vitamin supplementation may be a novel method for the intervention of PD, which is safer and more feasible than chemical drug treatment." @default.
- W4313826029 created "2023-01-09" @default.
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- W4313826029 date "2023-01-09" @default.
- W4313826029 modified "2023-09-25" @default.
- W4313826029 title "Vitamin B12 Ameliorates the Pathological Phenotypes of Multiple Parkinson’s Disease Models by Alleviating Oxidative Stress" @default.
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- W4313826029 cites W1588992136 @default.
- W4313826029 cites W1964054742 @default.
- W4313826029 cites W1983937216 @default.
- W4313826029 cites W1993826816 @default.
- W4313826029 cites W2007634950 @default.
- W4313826029 cites W2012270457 @default.
- W4313826029 cites W2036232174 @default.
- W4313826029 cites W2165128853 @default.
- W4313826029 cites W2531872507 @default.
- W4313826029 cites W2614383142 @default.
- W4313826029 cites W2739721831 @default.
- W4313826029 cites W2758520101 @default.
- W4313826029 cites W2768455179 @default.
- W4313826029 cites W2779446741 @default.
- W4313826029 cites W2784910549 @default.
- W4313826029 cites W2876414845 @default.
- W4313826029 cites W2885747263 @default.
- W4313826029 cites W2904739649 @default.
- W4313826029 cites W2911992820 @default.
- W4313826029 cites W2913717574 @default.
- W4313826029 cites W2915473202 @default.
- W4313826029 cites W2922123514 @default.
- W4313826029 cites W2922275293 @default.
- W4313826029 cites W2936059353 @default.
- W4313826029 cites W2954949966 @default.
- W4313826029 cites W2966271885 @default.
- W4313826029 cites W2969077908 @default.
- W4313826029 cites W2969573657 @default.
- W4313826029 cites W2976817835 @default.
- W4313826029 cites W2984910500 @default.
- W4313826029 cites W2988223062 @default.
- W4313826029 cites W2991729694 @default.
- W4313826029 cites W2996512340 @default.
- W4313826029 cites W2997491262 @default.
- W4313826029 cites W2997540594 @default.
- W4313826029 cites W3010932105 @default.
- W4313826029 cites W3013065729 @default.
- W4313826029 cites W3015011452 @default.
- W4313826029 cites W3015095871 @default.
- W4313826029 cites W3022038584 @default.
- W4313826029 cites W3024330147 @default.
- W4313826029 cites W3027940225 @default.
- W4313826029 cites W3036069297 @default.
- W4313826029 cites W3041151613 @default.
- W4313826029 cites W3044432427 @default.
- W4313826029 cites W3047628108 @default.
- W4313826029 cites W3081440049 @default.
- W4313826029 cites W3083456181 @default.
- W4313826029 cites W3087972244 @default.
- W4313826029 cites W3090032937 @default.
- W4313826029 cites W3094515282 @default.
- W4313826029 cites W3096732575 @default.
- W4313826029 cites W3109845574 @default.
- W4313826029 cites W3110165896 @default.
- W4313826029 cites W3121101323 @default.
- W4313826029 cites W3121998056 @default.
- W4313826029 cites W3153873471 @default.
- W4313826029 cites W3172899273 @default.
- W4313826029 cites W3198048866 @default.
- W4313826029 cites W3198174088 @default.
- W4313826029 cites W3205323704 @default.
- W4313826029 cites W3205415279 @default.
- W4313826029 cites W3209306683 @default.
- W4313826029 cites W3209360764 @default.
- W4313826029 cites W3211656792 @default.
- W4313826029 cites W3211876735 @default.
- W4313826029 cites W3212974276 @default.
- W4313826029 cites W4200150586 @default.
- W4313826029 cites W4200179082 @default.
- W4313826029 cites W4205537462 @default.
- W4313826029 cites W4206433545 @default.
- W4313826029 cites W4212986886 @default.
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- W4313826029 doi "https://doi.org/10.3390/antiox12010153" @default.
- W4313826029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36671015" @default.
- W4313826029 hasPublicationYear "2023" @default.
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