FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313826412> ?p ?o ?g. }

• W4313826412 endingPage "121" @default.
• W4313826412 startingPage "121" @default.
• W4313826412 abstract "Silver nanoparticles (AgNPs) have unlocked numerous novel disciplines in nanobiotechnological protocols due to their larger surface area-to-volume ratios, which are attributed to the marked reactivity of nanosilver, and due to their extremely small size, which enables AgNPs to enter cells, interact with organelles, and yield distinct biological effects. AgNPs are capable of bypassing immune cells, staying in the system for longer periods and with a higher distribution, reaching target tissues at higher concentrations, avoiding diffusion to adjacent tissues, releasing therapeutic agents or drugs for specific stimuli to achieve a longer duration at a specific rate, and yielding desired effects. The phytofabrication of AgNPs is a cost-effective, one-step, environmentally friendly, and easy method that harnesses sustainable resources and naturally available components of plant extracts (PEs). In addition, it processes various catalytic activities for the degradation of various organic pollutants. For the phytofabrication of AgNPs, plant products can be used in a multifunctional manner as a reducing agent, a stabilizing agent, and a functionalizing agent. In addition, they can be used to curtail the requirements for any additional stabilizing agents and to help the reaction stages subside. Azadirachta indica, a very common and prominent medicinal plant grown throughout the Indian subcontinent, possesses free radical scavenging and other pharmaceutical properties via the regulation of proinflammatory enzymes, such as COX and TOX. It also demonstrates anticancer activities through cell-signaling pathways, modulating tumor-suppressing genes such as p53 and pTEN, transcriptional factors, angiogenesis, and apoptosis via bcl2 and bax. In addition, it possesses antibacterial activities. Phytofabricated AgNPs have been applied in the areas of drug delivery, bioimaging, biosensing, cancer treatment, cosmetics, and cell biology. Such pharmaceutical and biological activities of phytofabricated AgNPs are attributed to more than 300 phytochemicals found in Azadirachta indica, and are especially abundant in flavonoids, polyphenols, diterpenoids, triterpenoids, limonoids, tannins, coumarin, nimbolide, azadirachtin, azadirone, azadiradione, and gedunin. Parts of Azadirachta indica, including the leaves in various forms, have been used for wound healing or as a repellent. This study was aimed at examining previously biosynthesized (from Azadirachta indica) AgNPs for anticancer, wound-healing, and antimicrobial actions (through MTT reduction assay, scratch assay, and microbroth dilution methods, respectively). Additionally, apoptosis in cancer cells and the antibiofilm capabilities of AgNPs were examined through caspase-3 expression, dentine block, and crystal violet methods. We found that biogenic silver nanoparticles are capable of inducing cytotoxicity in HCT-116 colon carcinoma cells (IC50 of 744.23 µg/mL, R2: 0.94), but are ineffective against MCF-7 breast cancer cells (IC50 >> 1000 µg/mL, R2: 0.86). AgNPs (IC50 value) induced a significant increase in caspase-3 expression (a 1.5-fold increase) in HCT-116, as compared with control cells. FITC-MFI was 1936 in HCT-116-treated cells, as compared to being 4551 in cisplatin and 1297 in untreated cells. AgNPs (6.26 µg/mL and 62.5 µg/mL) induced the cellular migration (40.2% and 33.23%, respectively) of V79 Chinese hamster lung fibroblasts; however, the improvement in wound healing was not significant as it was for the controls. AgNPs (MIC of 10 µg/mL) were very effective against MDR Enterococcus faecalis in the planktonic mode as well as in the biofilm mode. AgNPs (10 µg/mL and 320 µg/mL) reduced the E. faecalis biofilm by >50% and >80%, respectively. Natural products, such as Syzygium aromaticum (clove) oil (MIC of 312.5 µg/mL) and eugenol (MIC of 625 µg/mL), showed significant antimicrobial effects against A. indica. Our findings indicate that A. indica-functionalized AgNPs are effective against cancer cells and can induce apoptosis in HCT-116 colon carcinoma cells; however, the anticancer properties of AgNPs can also be upgraded through active targeting (functionalized with enzymes, antibiotics, photosensitizers, or antibodies) in immunotherapy, photothermal therapy, and photodynamic therapy. Our findings also suggest that functionalized AgNPs could be pivotal in the development of a novel, non-cytotoxic, biocompatible therapeutic agent for infected chronic wounds, ulcers, and skin lesions involving MDR pathogens via their incorporation into scaffolds, composites, patches, microgels, or formulations for microneedles, dressings, bandages, gels, or other drug-delivery systems." @default.
• W4313826412 created "2023-01-09" @default.
• W4313826412 creator A5008117210 @default.
• W4313826412 creator A5008603802 @default.
• W4313826412 creator A5036075038 @default.
• W4313826412 creator A5040939843 @default.
• W4313826412 creator A5054971565 @default.
• W4313826412 creator A5063312933 @default.
• W4313826412 creator A5071756086 @default.
• W4313826412 creator A5079119245 @default.
• W4313826412 date "2023-01-09" @default.
• W4313826412 modified "2023-10-14" @default.
• W4313826412 title "Silver Nanoparticles Phytofabricated through Azadirachta indica: Anticancer, Apoptotic, and Wound-Healing Properties" @default.
• W4313826412 cites W1277120899 @default.
• W4313826412 cites W1503907471 @default.
• W4313826412 cites W1557990487 @default.
• W4313826412 cites W1721241748 @default.
• W4313826412 cites W1810443953 @default.
• W4313826412 cites W1847535628 @default.
• W4313826412 cites W1912007726 @default.
• W4313826412 cites W193983472 @default.
• W4313826412 cites W1965006954 @default.
• W4313826412 cites W1965448558 @default.
• W4313826412 cites W1966439045 @default.
• W4313826412 cites W1974214452 @default.
• W4313826412 cites W1976667730 @default.
• W4313826412 cites W1977571062 @default.
• W4313826412 cites W1978653530 @default.
• W4313826412 cites W1978695076 @default.
• W4313826412 cites W1986120916 @default.
• W4313826412 cites W1986308133 @default.
• W4313826412 cites W1990185924 @default.
• W4313826412 cites W1991272056 @default.
• W4313826412 cites W1992932839 @default.
• W4313826412 cites W1998300881 @default.
• W4313826412 cites W1999035068 @default.
• W4313826412 cites W1999097921 @default.
• W4313826412 cites W1999770429 @default.
• W4313826412 cites W1999830563 @default.
• W4313826412 cites W2001926097 @default.
• W4313826412 cites W2003114988 @default.
• W4313826412 cites W2005216863 @default.
• W4313826412 cites W2006825440 @default.
• W4313826412 cites W2010616276 @default.
• W4313826412 cites W2011149129 @default.
• W4313826412 cites W2017443740 @default.
• W4313826412 cites W2018836714 @default.
• W4313826412 cites W2022792624 @default.
• W4313826412 cites W2023297738 @default.
• W4313826412 cites W2028897202 @default.
• W4313826412 cites W2030728789 @default.
• W4313826412 cites W2032152872 @default.
• W4313826412 cites W2039154211 @default.
• W4313826412 cites W2040107579 @default.
• W4313826412 cites W2040305097 @default.
• W4313826412 cites W2044407426 @default.
• W4313826412 cites W2054745605 @default.
• W4313826412 cites W2055187845 @default.
• W4313826412 cites W2061073363 @default.
• W4313826412 cites W2061151325 @default.
• W4313826412 cites W2062239780 @default.
• W4313826412 cites W2062726059 @default.
• W4313826412 cites W2062900498 @default.
• W4313826412 cites W2063346783 @default.
• W4313826412 cites W2064228423 @default.
• W4313826412 cites W2066610921 @default.
• W4313826412 cites W2066735594 @default.
• W4313826412 cites W2067422503 @default.
• W4313826412 cites W2071171251 @default.
• W4313826412 cites W2072113064 @default.
• W4313826412 cites W2079681862 @default.
• W4313826412 cites W2080669705 @default.
• W4313826412 cites W2082224684 @default.
• W4313826412 cites W2082657579 @default.
• W4313826412 cites W2090208884 @default.
• W4313826412 cites W2090994520 @default.
• W4313826412 cites W2091651320 @default.
• W4313826412 cites W2094262202 @default.
• W4313826412 cites W2095811515 @default.
• W4313826412 cites W2098300761 @default.
• W4313826412 cites W2099039284 @default.
• W4313826412 cites W2099460741 @default.
• W4313826412 cites W2100682047 @default.
• W4313826412 cites W2102270436 @default.
• W4313826412 cites W2102390837 @default.
• W4313826412 cites W2109684694 @default.
• W4313826412 cites W2117925143 @default.
• W4313826412 cites W2118378624 @default.
• W4313826412 cites W2119608865 @default.
• W4313826412 cites W2124228085 @default.
• W4313826412 cites W2125603952 @default.
• W4313826412 cites W2126661658 @default.
• W4313826412 cites W2127609756 @default.
• W4313826412 cites W2132328703 @default.
• W4313826412 cites W2136264312 @default.
• W4313826412 cites W2136772857 @default.
• W4313826412 cites W2138563426 @default.
• W4313826412 cites W2139221049 @default.

• next