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- W4313828092 abstract "Head and neck squamous cell carcinoma (HNSCC), the most common malignancy of the head and neck, has an overall 5-year survival rate of <50%. Genes associated with cuproptosis, a newly identified copper-dependent form of cell death, are aberrantly expressed in various tumours. However, their role in HNSCC remains unknown. In this study, bioinformatic analysis revealed that the cuproptosis-related gene CDKN2A was correlated with the malignant behaviour of HNSCC. Kaplan-Meier (KM) curves showed that patients with high CDKN2A expression had a better prognosis. Multiomic analysis revealed that CDKN2A may be associated with cell cycle and immune cell infiltration in the tumour microenvironment and is important for maintaining systemic homeostasis in the body. Furthermore, molecular docking and molecular dynamics simulations suggested strong binding between plicamycin and CDKN2A. And plicamycin inhibits the progression of HNSCC in cellular assays. In conclusion, this study elucidated a potential mechanism of action of the cuproptosis-associated gene CDKN2A in HNSCC and revealed that plicamycin targets CDKN2A to improve the prognosis of patients." @default.
- W4313828092 created "2023-01-09" @default.
- W4313828092 creator A5014898916 @default.
- W4313828092 creator A5046350751 @default.
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- W4313828092 creator A5086326013 @default.
- W4313828092 date "2023-01-09" @default.
- W4313828092 modified "2023-10-01" @default.
- W4313828092 title "Cuproptosis-associated CDKN2A is targeted by plicamycin to regulate the microenvironment in patients with head and neck squamous cell carcinoma" @default.
- W4313828092 cites W1227064712 @default.
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- W4313828092 cites W1980584100 @default.
- W4313828092 cites W1985213868 @default.
- W4313828092 cites W1991500417 @default.
- W4313828092 cites W1998068737 @default.
- W4313828092 cites W1998625299 @default.
- W4313828092 cites W2000650776 @default.
- W4313828092 cites W2019732936 @default.
- W4313828092 cites W2030758549 @default.
- W4313828092 cites W2033328517 @default.
- W4313828092 cites W2083850217 @default.
- W4313828092 cites W2092080516 @default.
- W4313828092 cites W2093260830 @default.
- W4313828092 cites W2094961514 @default.
- W4313828092 cites W2099900951 @default.
- W4313828092 cites W2101335891 @default.
- W4313828092 cites W2105103540 @default.
- W4313828092 cites W2115876761 @default.
- W4313828092 cites W2122982027 @default.
- W4313828092 cites W2123879591 @default.
- W4313828092 cites W2130410032 @default.
- W4313828092 cites W2141269240 @default.
- W4313828092 cites W2146512944 @default.
- W4313828092 cites W2158135353 @default.
- W4313828092 cites W2159675211 @default.
- W4313828092 cites W2159707944 @default.
- W4313828092 cites W2174734928 @default.
- W4313828092 cites W2230320310 @default.
- W4313828092 cites W2282664279 @default.
- W4313828092 cites W2298867408 @default.
- W4313828092 cites W2329659234 @default.
- W4313828092 cites W2337729923 @default.
- W4313828092 cites W2346066981 @default.
- W4313828092 cites W2626724458 @default.
- W4313828092 cites W2754761629 @default.
- W4313828092 cites W2795768114 @default.
- W4313828092 cites W2818473048 @default.
- W4313828092 cites W2889646458 @default.
- W4313828092 cites W2892113269 @default.
- W4313828092 cites W2895679848 @default.
- W4313828092 cites W2895926103 @default.
- W4313828092 cites W2898180335 @default.
- W4313828092 cites W2898709937 @default.
- W4313828092 cites W2907483852 @default.
- W4313828092 cites W2938964227 @default.
- W4313828092 cites W2947215881 @default.
- W4313828092 cites W2957177175 @default.
- W4313828092 cites W2980924315 @default.
- W4313828092 cites W3011895923 @default.
- W4313828092 cites W3033311558 @default.
- W4313828092 cites W3045354166 @default.
- W4313828092 cites W3089876884 @default.
- W4313828092 cites W3093710085 @default.
- W4313828092 cites W3096286467 @default.
- W4313828092 cites W3101935691 @default.
- W4313828092 cites W3107527779 @default.
- W4313828092 cites W3118557231 @default.
- W4313828092 cites W3162561971 @default.
- W4313828092 cites W3194027626 @default.
- W4313828092 cites W3194040044 @default.
- W4313828092 cites W3204113233 @default.
- W4313828092 cites W3207626241 @default.
- W4313828092 cites W3209449223 @default.
- W4313828092 cites W4205582508 @default.
- W4313828092 cites W4214862149 @default.
- W4313828092 cites W4221115671 @default.
- W4313828092 cites W4223597480 @default.
- W4313828092 cites W4226164756 @default.
- W4313828092 cites W4229441257 @default.
- W4313828092 cites W4246271082 @default.
- W4313828092 cites W4255156463 @default.
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- W4313828092 cites W4286630911 @default.
- W4313828092 cites W4287582625 @default.
- W4313828092 cites W4294026384 @default.
- W4313828092 cites W4294307374 @default.
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- W4313828092 doi "https://doi.org/10.3389/fgene.2022.1036408" @default.
- W4313828092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36699463" @default.
- W4313828092 hasPublicationYear "2023" @default.
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