Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313830075> ?p ?o ?g. }
- W4313830075 endingPage "129129" @default.
- W4313830075 startingPage "129129" @default.
- W4313830075 abstract "Mitochondria are considered to be a promising target in cancer diagnosis and therapeutics. Recently, sydnone and sydnonimine, as mesoionic bioorthogonal reagents, have been used in cell labeling and drug delivery. Here we investigated the mitochondrial targeting ability of sydnones and sydnonimines for the first time. Experimental results show that sydnone and sydnonimine themselves have high mitochondrial distribution. However, the introduction of a phenyl group into the C4 position of sydnone dramatically decreases the mitochondrial affinity. In addition, we took advantage of mitochondrial targeting ability and click-and-release reaction of sydnonimine to evaluate anticancer activities of in-mitochondria delivery of celecoxib against HeLa and HepG2 cells, indicating that celecoxib-induced cancer cell death may not involve mitochondria-related pathway." @default.
- W4313830075 created "2023-01-09" @default.
- W4313830075 creator A5051802294 @default.
- W4313830075 creator A5054076421 @default.
- W4313830075 creator A5054751834 @default.
- W4313830075 creator A5075181574 @default.
- W4313830075 date "2023-02-01" @default.
- W4313830075 modified "2023-09-25" @default.
- W4313830075 title "Investigation of mitochondrial targeting ability of sydnones and sydnonimines and mitochondria-targeted delivery of celecoxib" @default.
- W4313830075 cites W1986936335 @default.
- W4313830075 cites W1997999200 @default.
- W4313830075 cites W1998394615 @default.
- W4313830075 cites W2033498682 @default.
- W4313830075 cites W2036614632 @default.
- W4313830075 cites W2061232132 @default.
- W4313830075 cites W2078265076 @default.
- W4313830075 cites W2082812256 @default.
- W4313830075 cites W2128515425 @default.
- W4313830075 cites W2167370588 @default.
- W4313830075 cites W2172413067 @default.
- W4313830075 cites W2422039834 @default.
- W4313830075 cites W2509979833 @default.
- W4313830075 cites W2527466341 @default.
- W4313830075 cites W2728985030 @default.
- W4313830075 cites W2738457770 @default.
- W4313830075 cites W2745329991 @default.
- W4313830075 cites W2752175890 @default.
- W4313830075 cites W2752417205 @default.
- W4313830075 cites W2765349875 @default.
- W4313830075 cites W2803024865 @default.
- W4313830075 cites W2803724578 @default.
- W4313830075 cites W2901577511 @default.
- W4313830075 cites W2909369603 @default.
- W4313830075 cites W2913291946 @default.
- W4313830075 cites W2921174121 @default.
- W4313830075 cites W2931881563 @default.
- W4313830075 cites W2948416922 @default.
- W4313830075 cites W2951218774 @default.
- W4313830075 cites W2954698710 @default.
- W4313830075 cites W2954787793 @default.
- W4313830075 cites W2978493661 @default.
- W4313830075 cites W2981265021 @default.
- W4313830075 cites W2997124775 @default.
- W4313830075 cites W3018213314 @default.
- W4313830075 cites W3023762347 @default.
- W4313830075 cites W3029194172 @default.
- W4313830075 cites W3033711646 @default.
- W4313830075 cites W3042149067 @default.
- W4313830075 cites W3049046903 @default.
- W4313830075 cites W3080636803 @default.
- W4313830075 cites W3081136188 @default.
- W4313830075 cites W3083542949 @default.
- W4313830075 cites W3085879689 @default.
- W4313830075 cites W3086952981 @default.
- W4313830075 cites W3090745705 @default.
- W4313830075 cites W3093850074 @default.
- W4313830075 cites W3095793999 @default.
- W4313830075 cites W3107988949 @default.
- W4313830075 cites W3109763732 @default.
- W4313830075 cites W3118070825 @default.
- W4313830075 cites W3119331823 @default.
- W4313830075 cites W3164056401 @default.
- W4313830075 cites W3173128102 @default.
- W4313830075 cites W3176481378 @default.
- W4313830075 cites W3196158787 @default.
- W4313830075 cites W3199662196 @default.
- W4313830075 cites W3217293927 @default.
- W4313830075 cites W3217670286 @default.
- W4313830075 cites W4205216782 @default.
- W4313830075 cites W4206286691 @default.
- W4313830075 cites W4214771862 @default.
- W4313830075 cites W4220932636 @default.
- W4313830075 cites W4221037028 @default.
- W4313830075 doi "https://doi.org/10.1016/j.bmcl.2023.129129" @default.
- W4313830075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36634752" @default.
- W4313830075 hasPublicationYear "2023" @default.
- W4313830075 type Work @default.
- W4313830075 citedByCount "0" @default.
- W4313830075 crossrefType "journal-article" @default.
- W4313830075 hasAuthorship W4313830075A5051802294 @default.
- W4313830075 hasAuthorship W4313830075A5054076421 @default.
- W4313830075 hasAuthorship W4313830075A5054751834 @default.
- W4313830075 hasAuthorship W4313830075A5075181574 @default.
- W4313830075 hasConcept C121608353 @default.
- W4313830075 hasConcept C1491633281 @default.
- W4313830075 hasConcept C155647269 @default.
- W4313830075 hasConcept C178790620 @default.
- W4313830075 hasConcept C185592680 @default.
- W4313830075 hasConcept C190283241 @default.
- W4313830075 hasConcept C21951064 @default.
- W4313830075 hasConcept C2776467144 @default.
- W4313830075 hasConcept C2777366897 @default.
- W4313830075 hasConcept C2779044366 @default.
- W4313830075 hasConcept C2780378348 @default.
- W4313830075 hasConcept C2780569236 @default.
- W4313830075 hasConcept C28859421 @default.
- W4313830075 hasConcept C54355233 @default.
- W4313830075 hasConcept C55493867 @default.