Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313830083> ?p ?o ?g. }
- W4313830083 abstract "Abstract Background Uric acid, a formerly-known antioxidant that has recently been linked with many inflammatory diseases as a pro-inflammatory and -oxidative mediator in pathological conditions. It is imperative to reassess the association between periodontitis and uric acid in locally and systematically. The aim of this systematic review was to systemically evaluate the association of periodontitis with the uric acid (UA) levels in blood, saliva and gingival crevicular fluid (GCF). Methods Relevant clinical studies up to July 1, 2022 were identified and retrieved from electronic databases, with periodontitis, uric acid, hyperuricemia and gout as the keywords. Weighted (WMD) or standardized mean difference (SMD) was calculated using fixed- or random-effect models. Methodological heterogeneity was assessed. Results Fifteen eligible retrospective studies (blood, n = 7; saliva, n = 8; GCF, n = 1) were enrolled, which included 1302 patients with periodontitis and 916 controls. Meta-analysis demonstrated a statistically enhanced blood UA content ( WMD = 0.49 mg/dL, 95% CI : 0.02 to 0.96, P = 0.042) but decreased salivary UA level ( SMD = -0.95, 95% CI : -1.23 to -0.68, P < 0.001) in periodontitis versus control. Statistical heterogeneity was significant among studies involving blood ( I 2 = 94.3%, P < 0.001) but not saliva ( I 2 = 33.8%, P = 0.196). Conclusions Periodontitis is associated with higher UA levels in blood and lower UA levels in saliva. The indicative mechanisms need to be verified by further clinical and experimental studies. (Registration no. CRD42020172535 in Prospero)." @default.
- W4313830083 created "2023-01-09" @default.
- W4313830083 creator A5027596703 @default.
- W4313830083 creator A5036304949 @default.
- W4313830083 creator A5040842488 @default.
- W4313830083 creator A5062474742 @default.
- W4313830083 creator A5069144689 @default.
- W4313830083 date "2023-01-09" @default.
- W4313830083 modified "2023-10-18" @default.
- W4313830083 title "Association between periodontitis and uric acid levels in blood and oral fluids: A systematic review and meta-analysis" @default.
- W4313830083 cites W1844518775 @default.
- W4313830083 cites W1964751764 @default.
- W4313830083 cites W1967449574 @default.
- W4313830083 cites W1973455669 @default.
- W4313830083 cites W1974604476 @default.
- W4313830083 cites W1980273143 @default.
- W4313830083 cites W1985969855 @default.
- W4313830083 cites W1985973786 @default.
- W4313830083 cites W1991633185 @default.
- W4313830083 cites W1993616037 @default.
- W4313830083 cites W2001058881 @default.
- W4313830083 cites W2015674218 @default.
- W4313830083 cites W2031543116 @default.
- W4313830083 cites W2033585778 @default.
- W4313830083 cites W2038416402 @default.
- W4313830083 cites W2040286046 @default.
- W4313830083 cites W2050022795 @default.
- W4313830083 cites W2061460715 @default.
- W4313830083 cites W2066151306 @default.
- W4313830083 cites W2090163682 @default.
- W4313830083 cites W2105450122 @default.
- W4313830083 cites W2110792293 @default.
- W4313830083 cites W2117084079 @default.
- W4313830083 cites W2126355581 @default.
- W4313830083 cites W2126930838 @default.
- W4313830083 cites W2147331510 @default.
- W4313830083 cites W2152371422 @default.
- W4313830083 cites W2157823046 @default.
- W4313830083 cites W2158122734 @default.
- W4313830083 cites W2174784305 @default.
- W4313830083 cites W2195980900 @default.
- W4313830083 cites W2513392623 @default.
- W4313830083 cites W2526806864 @default.
- W4313830083 cites W2528206633 @default.
- W4313830083 cites W2560293017 @default.
- W4313830083 cites W2567362164 @default.
- W4313830083 cites W2591124526 @default.
- W4313830083 cites W2755439711 @default.
- W4313830083 cites W2767392813 @default.
- W4313830083 cites W2793035264 @default.
- W4313830083 cites W2803184214 @default.
- W4313830083 cites W2808724744 @default.
- W4313830083 cites W2809923735 @default.
- W4313830083 cites W2890179758 @default.
- W4313830083 cites W2890625506 @default.
- W4313830083 cites W2891827948 @default.
- W4313830083 cites W2897064181 @default.
- W4313830083 cites W2899372932 @default.
- W4313830083 cites W2909009987 @default.
- W4313830083 cites W2911679322 @default.
- W4313830083 cites W2913420806 @default.
- W4313830083 cites W2916074836 @default.
- W4313830083 cites W2937739421 @default.
- W4313830083 cites W2957527083 @default.
- W4313830083 cites W2972196633 @default.
- W4313830083 cites W2978799435 @default.
- W4313830083 cites W2981509309 @default.
- W4313830083 cites W2985990135 @default.
- W4313830083 cites W2993250474 @default.
- W4313830083 cites W2999204701 @default.
- W4313830083 cites W3049075383 @default.
- W4313830083 cites W3111607754 @default.
- W4313830083 cites W3125249206 @default.
- W4313830083 cites W3135199876 @default.
- W4313830083 cites W3135923529 @default.
- W4313830083 cites W3161323900 @default.
- W4313830083 cites W3164603392 @default.
- W4313830083 cites W3201706640 @default.
- W4313830083 cites W4200191093 @default.
- W4313830083 cites W4213459206 @default.
- W4313830083 cites W4293860874 @default.
- W4313830083 cites W4294215472 @default.
- W4313830083 cites W4295177519 @default.
- W4313830083 cites W4300977174 @default.
- W4313830083 cites W4323906708 @default.
- W4313830083 doi "https://doi.org/10.21203/rs.3.rs-2251617/v1" @default.
- W4313830083 hasPublicationYear "2023" @default.
- W4313830083 type Work @default.
- W4313830083 citedByCount "0" @default.
- W4313830083 crossrefType "posted-content" @default.
- W4313830083 hasAuthorship W4313830083A5027596703 @default.
- W4313830083 hasAuthorship W4313830083A5036304949 @default.
- W4313830083 hasAuthorship W4313830083A5040842488 @default.
- W4313830083 hasAuthorship W4313830083A5062474742 @default.
- W4313830083 hasAuthorship W4313830083A5069144689 @default.
- W4313830083 hasBestOaLocation W43138300831 @default.
- W4313830083 hasConcept C126322002 @default.
- W4313830083 hasConcept C207886595 @default.
- W4313830083 hasConcept C2779721657 @default.
- W4313830083 hasConcept C2779881121 @default.