FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313830333> ?p ?o ?g. }

• W4313830333 abstract "Abstract Isolation and manipulation of single cells play a crucial role in drug screening. However, previously reported single-cell drug screening lacks multiple-dose concentration gradient studies, which will limit the ability to accurately predict drug performance. To solve this problem, we constructed a multi-concentration gradient generator, in which a Tai Chi-spiral mixer can accelerate the mixing of solution in a short time and then produce a linear concentration gradient. Later, a gradient generator combined with a single-cell capture array was adopted to investigate the effects of single or combined doses of 5-fluorouracil and cisplatin on HepG2 and MCF-7 cells at the single-cell level. The results showed that both drugs were effective in inhibiting the growth of cancer cells, and the combination was more effective for HepG2 cells. In addition, the relationship between biomechanical heterogeneity (e.g., deformability and size) of tumor cells and potential drug resistance at single-cell level was investigated, indicating that small and/or deformable cells were more resistant than large and/or less deformable cells. The device provides a simple and reliable platform for studying the optimal dosage of different drug candidates at the single-cell level and effectively screening single-agent chemotherapy regimens and combination therapies." @default.
• W4313830333 created "2023-01-09" @default.
• W4313830333 creator A5020618441 @default.
• W4313830333 creator A5034064947 @default.
• W4313830333 creator A5044231894 @default.
• W4313830333 creator A5055162501 @default.
• W4313830333 creator A5064842058 @default.
• W4313830333 creator A5077895438 @default.
• W4313830333 creator A5087239421 @default.
• W4313830333 date "2023-01-09" @default.
• W4313830333 modified "2023-09-30" @default.
• W4313830333 title "Construction of multiple concentration gradients for single-cell level drug screening" @default.
• W4313830333 cites W1534187989 @default.
• W4313830333 cites W1968048579 @default.
• W4313830333 cites W1987777080 @default.
• W4313830333 cites W1995089537 @default.
• W4313830333 cites W2009766076 @default.
• W4313830333 cites W2031770999 @default.
• W4313830333 cites W2044193480 @default.
• W4313830333 cites W2129267808 @default.
• W4313830333 cites W2188221215 @default.
• W4313830333 cites W2208361805 @default.
• W4313830333 cites W2321394961 @default.
• W4313830333 cites W2531079703 @default.
• W4313830333 cites W2606741877 @default.
• W4313830333 cites W2621425644 @default.
• W4313830333 cites W2756411352 @default.
• W4313830333 cites W2889234687 @default.
• W4313830333 cites W2896002881 @default.
• W4313830333 cites W2901993713 @default.
• W4313830333 cites W2903334864 @default.
• W4313830333 cites W2907192800 @default.
• W4313830333 cites W2913222196 @default.
• W4313830333 cites W2922224588 @default.
• W4313830333 cites W2923908559 @default.
• W4313830333 cites W2975345404 @default.
• W4313830333 cites W3024801519 @default.
• W4313830333 cites W3083295733 @default.
• W4313830333 cites W3113877554 @default.
• W4313830333 cites W3123357811 @default.
• W4313830333 cites W3162278039 @default.
• W4313830333 cites W3205138858 @default.
• W4313830333 cites W3216049862 @default.
• W4313830333 cites W3217087721 @default.
• W4313830333 cites W4221124140 @default.
• W4313830333 doi "https://doi.org/10.21203/rs.3.rs-2432577/v1" @default.
• W4313830333 hasPublicationYear "2023" @default.
• W4313830333 type Work @default.
• W4313830333 citedByCount "0" @default.
• W4313830333 crossrefType "posted-content" @default.
• W4313830333 hasAuthorship W4313830333A5020618441 @default.
• W4313830333 hasAuthorship W4313830333A5034064947 @default.
• W4313830333 hasAuthorship W4313830333A5044231894 @default.
• W4313830333 hasAuthorship W4313830333A5055162501 @default.
• W4313830333 hasAuthorship W4313830333A5064842058 @default.
• W4313830333 hasAuthorship W4313830333A5077895438 @default.
• W4313830333 hasAuthorship W4313830333A5087239421 @default.
• W4313830333 hasBestOaLocation W43138303331 @default.
• W4313830333 hasConcept C12554922 @default.
• W4313830333 hasConcept C126322002 @default.
• W4313830333 hasConcept C136229726 @default.
• W4313830333 hasConcept C1491633281 @default.
• W4313830333 hasConcept C171250308 @default.
• W4313830333 hasConcept C185592680 @default.
• W4313830333 hasConcept C192562407 @default.
• W4313830333 hasConcept C2776694085 @default.
• W4313830333 hasConcept C2776950831 @default.
• W4313830333 hasConcept C2778239845 @default.
• W4313830333 hasConcept C2779820397 @default.
• W4313830333 hasConcept C2780035454 @default.
• W4313830333 hasConcept C3018453882 @default.
• W4313830333 hasConcept C43617362 @default.
• W4313830333 hasConcept C55493867 @default.
• W4313830333 hasConcept C71924100 @default.
• W4313830333 hasConcept C86803240 @default.
• W4313830333 hasConcept C98274493 @default.
• W4313830333 hasConceptScore W4313830333C12554922 @default.
• W4313830333 hasConceptScore W4313830333C126322002 @default.
• W4313830333 hasConceptScore W4313830333C136229726 @default.
• W4313830333 hasConceptScore W4313830333C1491633281 @default.
• W4313830333 hasConceptScore W4313830333C171250308 @default.
• W4313830333 hasConceptScore W4313830333C185592680 @default.
• W4313830333 hasConceptScore W4313830333C192562407 @default.
• W4313830333 hasConceptScore W4313830333C2776694085 @default.
• W4313830333 hasConceptScore W4313830333C2776950831 @default.
• W4313830333 hasConceptScore W4313830333C2778239845 @default.
• W4313830333 hasConceptScore W4313830333C2779820397 @default.
• W4313830333 hasConceptScore W4313830333C2780035454 @default.
• W4313830333 hasConceptScore W4313830333C3018453882 @default.
• W4313830333 hasConceptScore W4313830333C43617362 @default.
• W4313830333 hasConceptScore W4313830333C55493867 @default.
• W4313830333 hasConceptScore W4313830333C71924100 @default.
• W4313830333 hasConceptScore W4313830333C86803240 @default.
• W4313830333 hasConceptScore W4313830333C98274493 @default.
• W4313830333 hasLocation W43138303331 @default.
• W4313830333 hasLocation W43138303332 @default.
• W4313830333 hasOpenAccess W4313830333 @default.
• W4313830333 hasPrimaryLocation W43138303331 @default.
• W4313830333 hasRelatedWork W2069859065 @default.
• W4313830333 hasRelatedWork W2355080005 @default.

• next