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- W4313839702 abstract "Singlet oxygen (1O2) has been recently identified as a key molecule against toxic Aβ aggregation, which is associated with the currently incurable Alzheimer's disease (AD). However, limited research has studied its efficiency against tau protein aggregation, the other major hallmark of AD. Herein, we designed and synthesized boron-dipyrromethene (BODIPY)-ruthenium conjugates and isolated three isomers. Under visible-light irradiation, the ε isomer can be photoactivated and efficiently generate singlet oxygen. Particularly, the complex demonstrated successful results in attenuating tauopathy─an appreciable decrease to 43 ± 2% at 100 nM. The photosensitizer was further found to remarkably promote neurite outgrowth and significantly increased the length and number of neurites in nerve cells. As a result of effective photoinduced singlet oxygen generation and proactive neurite outgrowth, the hybrid design has great potential for therapeutics for Alzheimer's disease." @default.
- W4313839702 created "2023-01-09" @default.
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- W4313839702 date "2023-01-09" @default.
- W4313839702 modified "2023-10-15" @default.
- W4313839702 title "Highly Efficient Singlet Oxygen Generation by BODIPY–Ruthenium(II) Complexes for Promoting Neurite Outgrowth and Suppressing Tau Protein Aggregation" @default.
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- W4313839702 doi "https://doi.org/10.1021/acs.inorgchem.2c03017" @default.
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