FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313854895> ?p ?o ?g. }

• W4313854895 endingPage "114232" @default.
• W4313854895 startingPage "114232" @default.
• W4313854895 abstract "Occurrence of hand-foot syndrome (HFS) during capecitabine treatment often results in treatment interruptions (26 %) or treatment discontinuation (17 %), and can severely decrease quality of life. In this study, we investigated whether single nucleotide polymorphisms (SNPs) in genes involved in capecitabine metabolism - other than DPYD - are associated with an increased risk for capecitabine-induced HFS.Patients treated with capecitabine according to standard of care were enrolled after providing written informed consent for genotyping purposes. Prospectively collected blood samples were used to extract genomic DNA, which was subsequently genotyped for SNPs in CES1, CES2 and CDA. SNPs and clinical baseline factors that were univariably associated with HFS with P ≤ 0.10, were tested in a multivariable model using logistic regression.Of the 446 patients eligible for analysis, 146 (32.7 %) developed HFS, of whom 77 patients (17.3 %) experienced HFS ≥ grade 2. In the multivariable model, CES1 1165-33 C>A (rs2244613, minor allele frequency 19 %) and CDA 266 + 242 A>G (rs10916825, minor allele frequency 35 %) variant allele carriers were at higher risk of HFS ≥ grade 2 (OR 1.888; 95 %CI 1.075-3.315; P = 0.027 and OR 1.865; 95 %CI 1.087-3.200; P = 0.024, respectively).We showed that CES1 1165-33 C>A and CDA 266 + 242 A>G are significantly associated with HFS grade 2 and grade 3 in patients treated with capecitabine. Prospective studies should assess whether this increased risk can be mitigated in carriers of these SNPs, when pre-emptive genotyping is being followed by dose adjustment or by alternative treatment by a fluoropyrimidine that is not substrate to CES1, such as S1." @default.
• W4313854895 created "2023-01-10" @default.
• W4313854895 creator A5021822394 @default.
• W4313854895 creator A5034477516 @default.
• W4313854895 creator A5035333937 @default.
• W4313854895 creator A5045236213 @default.
• W4313854895 creator A5049769702 @default.
• W4313854895 creator A5050202217 @default.
• W4313854895 creator A5053971929 @default.
• W4313854895 creator A5074174053 @default.
• W4313854895 creator A5076288352 @default.
• W4313854895 creator A5078260564 @default.
• W4313854895 creator A5091815146 @default.
• W4313854895 date "2023-03-01" @default.
• W4313854895 modified "2023-10-18" @default.
• W4313854895 title "Capecitabine-induced hand-foot syndrome: A pharmacogenetic study beyond DPYD" @default.
• W4313854895 cites W1576005490 @default.
• W4313854895 cites W1984328540 @default.
• W4313854895 cites W1994685129 @default.
• W4313854895 cites W2010700304 @default.
• W4313854895 cites W2044970916 @default.
• W4313854895 cites W2063653450 @default.
• W4313854895 cites W2097758359 @default.
• W4313854895 cites W2098584035 @default.
• W4313854895 cites W2100530362 @default.
• W4313854895 cites W2122152991 @default.
• W4313854895 cites W2122667952 @default.
• W4313854895 cites W2134806571 @default.
• W4313854895 cites W2138926750 @default.
• W4313854895 cites W2144791212 @default.
• W4313854895 cites W2146367048 @default.
• W4313854895 cites W2163967375 @default.
• W4313854895 cites W2174633205 @default.
• W4313854895 cites W2194156281 @default.
• W4313854895 cites W2520630506 @default.
• W4313854895 cites W2528523319 @default.
• W4313854895 cites W2550912777 @default.
• W4313854895 cites W2584698372 @default.
• W4313854895 cites W2603379213 @default.
• W4313854895 cites W2604669331 @default.
• W4313854895 cites W2618058692 @default.
• W4313854895 cites W2750095366 @default.
• W4313854895 cites W2896913847 @default.
• W4313854895 cites W2903768375 @default.
• W4313854895 cites W2923282967 @default.
• W4313854895 cites W2938142266 @default.
• W4313854895 cites W2972568882 @default.
• W4313854895 cites W3024906246 @default.
• W4313854895 cites W3087795120 @default.
• W4313854895 cites W3120013640 @default.
• W4313854895 cites W3134581972 @default.
• W4313854895 cites W4220893249 @default.
• W4313854895 cites W4220997652 @default.
• W4313854895 doi "https://doi.org/10.1016/j.biopha.2023.114232" @default.
• W4313854895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36630849" @default.
• W4313854895 hasPublicationYear "2023" @default.
• W4313854895 type Work @default.
• W4313854895 citedByCount "2" @default.
• W4313854895 countsByYear W43138548952023 @default.
• W4313854895 crossrefType "journal-article" @default.
• W4313854895 hasAuthorship W4313854895A5021822394 @default.
• W4313854895 hasAuthorship W4313854895A5034477516 @default.
• W4313854895 hasAuthorship W4313854895A5035333937 @default.
• W4313854895 hasAuthorship W4313854895A5045236213 @default.
• W4313854895 hasAuthorship W4313854895A5049769702 @default.
• W4313854895 hasAuthorship W4313854895A5050202217 @default.
• W4313854895 hasAuthorship W4313854895A5053971929 @default.
• W4313854895 hasAuthorship W4313854895A5074174053 @default.
• W4313854895 hasAuthorship W4313854895A5076288352 @default.
• W4313854895 hasAuthorship W4313854895A5078260564 @default.
• W4313854895 hasAuthorship W4313854895A5091815146 @default.
• W4313854895 hasBestOaLocation W43138548951 @default.
• W4313854895 hasConcept C104317684 @default.
• W4313854895 hasConcept C121608353 @default.
• W4313854895 hasConcept C126322002 @default.
• W4313854895 hasConcept C135763542 @default.
• W4313854895 hasConcept C143998085 @default.
• W4313854895 hasConcept C153209595 @default.
• W4313854895 hasConcept C157410074 @default.
• W4313854895 hasConcept C180754005 @default.
• W4313854895 hasConcept C188816634 @default.
• W4313854895 hasConcept C2777909004 @default.
• W4313854895 hasConcept C2778715236 @default.
• W4313854895 hasConcept C2779655350 @default.
• W4313854895 hasConcept C31467283 @default.
• W4313854895 hasConcept C526805850 @default.
• W4313854895 hasConcept C54355233 @default.
• W4313854895 hasConcept C55775858 @default.
• W4313854895 hasConcept C71924100 @default.
• W4313854895 hasConcept C86803240 @default.
• W4313854895 hasConcept C90924648 @default.
• W4313854895 hasConceptScore W4313854895C104317684 @default.
• W4313854895 hasConceptScore W4313854895C121608353 @default.
• W4313854895 hasConceptScore W4313854895C126322002 @default.
• W4313854895 hasConceptScore W4313854895C135763542 @default.
• W4313854895 hasConceptScore W4313854895C143998085 @default.
• W4313854895 hasConceptScore W4313854895C153209595 @default.
• W4313854895 hasConceptScore W4313854895C157410074 @default.

• next