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- W4313854937 startingPage "111941" @default.
- W4313854937 abstract "Activating the macrophage NLRP3 inflammasome can promote excessive inflammation with severe cell and tissue damage and organ dysfunction. Here, we show that pharmacological or genetic inhibition of pyruvate dehydrogenase kinase (PDHK) significantly attenuates NLRP3 inflammasome activation in murine and human macrophages and septic mice by lowering caspase-1 cleavage and interleukin-1β (IL-1β) secretion. Inhibiting PDHK reverses NLRP3 inflammasome-induced metabolic reprogramming, enhances autophagy, promotes mitochondrial fusion over fission, preserves crista ultrastructure, and attenuates mitochondrial reactive oxygen species (ROS) production. The suppressive effect of PDHK inhibition on the NLRP3 inflammasome is independent of its canonical role as a pyruvate dehydrogenase regulator. Our study suggests a non-canonical role of mitochondrial PDHK in promoting mitochondrial stress and supporting NLRP3 inflammasome activation during acute inflammation." @default.
- W4313854937 created "2023-01-10" @default.
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- W4313854937 date "2023-01-01" @default.
- W4313854937 modified "2023-10-16" @default.
- W4313854937 title "Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation" @default.
- W4313854937 cites W1526834337 @default.
- W4313854937 cites W1864325817 @default.
- W4313854937 cites W1882905539 @default.
- W4313854937 cites W1942767863 @default.
- W4313854937 cites W1960974681 @default.
- W4313854937 cites W1981310416 @default.
- W4313854937 cites W1985538633 @default.
- W4313854937 cites W1990960031 @default.
- W4313854937 cites W2001946532 @default.
- W4313854937 cites W2007747853 @default.
- W4313854937 cites W2012885541 @default.
- W4313854937 cites W2018563185 @default.
- W4313854937 cites W2023283007 @default.
- W4313854937 cites W2023368253 @default.
- W4313854937 cites W2024591203 @default.
- W4313854937 cites W2025673880 @default.
- W4313854937 cites W2034087770 @default.
- W4313854937 cites W2042767581 @default.
- W4313854937 cites W2045953344 @default.
- W4313854937 cites W2048030072 @default.
- W4313854937 cites W2054571187 @default.
- W4313854937 cites W2055727949 @default.
- W4313854937 cites W2064173000 @default.
- W4313854937 cites W2067406680 @default.
- W4313854937 cites W2070461642 @default.
- W4313854937 cites W2076062022 @default.
- W4313854937 cites W2080827095 @default.
- W4313854937 cites W2081311904 @default.
- W4313854937 cites W2088417711 @default.
- W4313854937 cites W2089532303 @default.
- W4313854937 cites W2109070574 @default.
- W4313854937 cites W2113010696 @default.
- W4313854937 cites W2114740264 @default.
- W4313854937 cites W2117473633 @default.
- W4313854937 cites W2117931978 @default.
- W4313854937 cites W2120521980 @default.
- W4313854937 cites W2143102054 @default.
- W4313854937 cites W2155643523 @default.
- W4313854937 cites W2158506244 @default.
- W4313854937 cites W2166006356 @default.
- W4313854937 cites W2176443454 @default.
- W4313854937 cites W2218496732 @default.
- W4313854937 cites W2296531152 @default.
- W4313854937 cites W2477941193 @default.
- W4313854937 cites W2517997111 @default.
- W4313854937 cites W2522038806 @default.
- W4313854937 cites W2613251895 @default.
- W4313854937 cites W2738586660 @default.
- W4313854937 cites W2790058489 @default.
- W4313854937 cites W2794913319 @default.
- W4313854937 cites W2795682982 @default.
- W4313854937 cites W2884912010 @default.
- W4313854937 cites W2887523061 @default.
- W4313854937 cites W2898685743 @default.
- W4313854937 cites W2903051467 @default.
- W4313854937 cites W2944725083 @default.
- W4313854937 cites W2988152617 @default.
- W4313854937 cites W2998105584 @default.
- W4313854937 cites W3022877454 @default.
- W4313854937 cites W3026959467 @default.
- W4313854937 cites W3045537494 @default.
- W4313854937 cites W3048446878 @default.
- W4313854937 cites W3080259742 @default.
- W4313854937 cites W3095964165 @default.
- W4313854937 cites W3103939314 @default.
- W4313854937 cites W3131347812 @default.
- W4313854937 cites W3133604326 @default.
- W4313854937 cites W3134293024 @default.
- W4313854937 cites W3134372233 @default.
- W4313854937 cites W3171139414 @default.
- W4313854937 cites W3191928958 @default.
- W4313854937 cites W4210564278 @default.
- W4313854937 cites W4225137755 @default.
- W4313854937 cites W4225159577 @default.
- W4313854937 cites W4225890110 @default.