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- W4313855087 abstract "Rapamycin (sirolimus) is an immunosuppressive drug approved by the Food and Drug Administration (FDA). It is also a leading candidate for targeting aging. Rapamycin and its analogs (everolimus, temsirolimus, ridaforolimus) inhibit the mammalian target of rapamycin (mTOR) kinase by binding to FK506-binding proteins (FKBP) and have a similar chemical structure that only differs in the functional group present at carbon-40. Analogs of rapamycin were developed to improve its pharmacological properties, such as low oral bioavailability and a long half-life. The analogs of rapamycin are referred to as “rapalogs.” Rapamycin is the parent compound and should therewith not be called a “rapalog.”" @default.
- W4313855087 created "2023-01-10" @default.
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- W4313855087 date "2023-01-01" @default.
- W4313855087 modified "2023-09-25" @default.
- W4313855087 title "Why Is Rapamycin Not a Rapalog?" @default.
- W4313855087 doi "https://doi.org/10.1159/000528985" @default.
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