Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313855461> ?p ?o ?g. }
- W4313855461 abstract "Abstract Objectives Chronic pancreatitis (CP) is an inflammatory disease that affects the absorption of nutrients like fats. Molecular signaling in pancreatic cells can be influenced by fatty acids (FAs) and changes in FA abundance could impact CP-associated complications. Here, we investigated FA abundance in CP compared to controls and explored how CP-associated complications and risk factors affect FA abundance. Methods Blood and clinical parameters were collected from subjects with (n=47) and without CP (n=22). Plasma was analyzed for relative FA abundance using gas chromatography and compared between controls and CP. Changes in FA abundance due to clinical parameters were also assessed in both groups. Results Decreased relative abundance of polyunsaturated fatty acids (PUFAs) and increased monounsaturated fatty acids (MUFAs) were observed in subjects with CP in a sex-dependent manner. The relative abundance of linoleic acid increased, and oleic acid decreased in CP subjects with exocrine pancreatic dysfunction and a history of substance abuse. Conclusions Plasma FAs like linoleic acid are dysregulated in CP in a sex-dependent manner. Additionally, risk factors and metabolic dysfunction further dysregulate FA abundance in CP. These results enhance our understanding of CP and highlight potential novel targets and metabolism-related pathways for treating CP." @default.
- W4313855461 created "2023-01-10" @default.
- W4313855461 creator A5004563285 @default.
- W4313855461 creator A5005449102 @default.
- W4313855461 creator A5005851718 @default.
- W4313855461 creator A5006351228 @default.
- W4313855461 creator A5012767113 @default.
- W4313855461 creator A5013534015 @default.
- W4313855461 creator A5015758374 @default.
- W4313855461 creator A5032770180 @default.
- W4313855461 creator A5036774311 @default.
- W4313855461 creator A5044039228 @default.
- W4313855461 creator A5048114747 @default.
- W4313855461 creator A5066772046 @default.
- W4313855461 creator A5070856467 @default.
- W4313855461 creator A5083056277 @default.
- W4313855461 creator A5090788654 @default.
- W4313855461 date "2023-01-09" @default.
- W4313855461 modified "2023-09-23" @default.
- W4313855461 title "Changes in Plasma Fatty Acid Abundance Related to Chronic Pancreatitis: A Pilot Study" @default.
- W4313855461 cites W1486117034 @default.
- W4313855461 cites W1498897377 @default.
- W4313855461 cites W1916661535 @default.
- W4313855461 cites W1957489287 @default.
- W4313855461 cites W1968955399 @default.
- W4313855461 cites W2000050828 @default.
- W4313855461 cites W2011196586 @default.
- W4313855461 cites W2022431463 @default.
- W4313855461 cites W2035942160 @default.
- W4313855461 cites W2047438155 @default.
- W4313855461 cites W2053302654 @default.
- W4313855461 cites W2064588805 @default.
- W4313855461 cites W2072370509 @default.
- W4313855461 cites W2078272869 @default.
- W4313855461 cites W2112183383 @default.
- W4313855461 cites W2136294049 @default.
- W4313855461 cites W2162311644 @default.
- W4313855461 cites W2304258614 @default.
- W4313855461 cites W2306583935 @default.
- W4313855461 cites W2583778511 @default.
- W4313855461 cites W2604660883 @default.
- W4313855461 cites W2740786566 @default.
- W4313855461 cites W2753908029 @default.
- W4313855461 cites W2796368387 @default.
- W4313855461 cites W2799676937 @default.
- W4313855461 cites W2804034649 @default.
- W4313855461 cites W2808956335 @default.
- W4313855461 cites W2913921969 @default.
- W4313855461 cites W2946173135 @default.
- W4313855461 cites W2964783773 @default.
- W4313855461 cites W2971291901 @default.
- W4313855461 cites W2991341437 @default.
- W4313855461 cites W3030932153 @default.
- W4313855461 cites W3048423992 @default.
- W4313855461 cites W3088813603 @default.
- W4313855461 cites W3089531206 @default.
- W4313855461 cites W3119810912 @default.
- W4313855461 cites W3164592820 @default.
- W4313855461 cites W4211046208 @default.
- W4313855461 cites W4220832664 @default.
- W4313855461 cites W4283729115 @default.
- W4313855461 cites W4288033308 @default.
- W4313855461 cites W1981120590 @default.
- W4313855461 doi "https://doi.org/10.1101/2023.01.05.522899" @default.
- W4313855461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36711757" @default.
- W4313855461 hasPublicationYear "2023" @default.
- W4313855461 type Work @default.
- W4313855461 citedByCount "0" @default.
- W4313855461 crossrefType "posted-content" @default.
- W4313855461 hasAuthorship W4313855461A5004563285 @default.
- W4313855461 hasAuthorship W4313855461A5005449102 @default.
- W4313855461 hasAuthorship W4313855461A5005851718 @default.
- W4313855461 hasAuthorship W4313855461A5006351228 @default.
- W4313855461 hasAuthorship W4313855461A5012767113 @default.
- W4313855461 hasAuthorship W4313855461A5013534015 @default.
- W4313855461 hasAuthorship W4313855461A5015758374 @default.
- W4313855461 hasAuthorship W4313855461A5032770180 @default.
- W4313855461 hasAuthorship W4313855461A5036774311 @default.
- W4313855461 hasAuthorship W4313855461A5044039228 @default.
- W4313855461 hasAuthorship W4313855461A5048114747 @default.
- W4313855461 hasAuthorship W4313855461A5066772046 @default.
- W4313855461 hasAuthorship W4313855461A5070856467 @default.
- W4313855461 hasAuthorship W4313855461A5083056277 @default.
- W4313855461 hasAuthorship W4313855461A5090788654 @default.
- W4313855461 hasBestOaLocation W43138554611 @default.
- W4313855461 hasConcept C122325731 @default.
- W4313855461 hasConcept C126322002 @default.
- W4313855461 hasConcept C134018914 @default.
- W4313855461 hasConcept C185592680 @default.
- W4313855461 hasConcept C18903297 @default.
- W4313855461 hasConcept C19038510 @default.
- W4313855461 hasConcept C2775967933 @default.
- W4313855461 hasConcept C2780809830 @default.
- W4313855461 hasConcept C2781403372 @default.
- W4313855461 hasConcept C543025807 @default.
- W4313855461 hasConcept C55493867 @default.
- W4313855461 hasConcept C71924100 @default.
- W4313855461 hasConcept C77077793 @default.
- W4313855461 hasConcept C86803240 @default.
- W4313855461 hasConceptScore W4313855461C122325731 @default.