FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313856685> ?p ?o ?g. }

• W4313856685 endingPage "239" @default.
• W4313856685 startingPage "231" @default.
• W4313856685 abstract "Experimental animal study.This study aims to investigate the effects of treatment with human neural stem cell (HNSC) secretomes on subacute spinal cord injury (SCI) post-laminectomy by analyzing interleukin-10 (IL-10), matrix metalloproteinase 9 (MMP9), transforming growth factor-β (TGF-β), and Basso-Beattie-Bresnahan (BBB) score locomotors as expressions of neurological recovery.In the United States, SCI has a recovery rate of 0.08%, tetraplegia 58.7%, and paraplegia 40.6%. Therapeutic approaches to SCI have focused on modulating the secondary cascade to prevent neurological deterioration and glial scar formation. Increasing evidence has shown that the success of cell-based SCI therapy is attributed to the secretomes rather than the cells themselves, but the effect of treatment with HNSC secretomes in SCI is unclear.This experimental study investigated 15 Rattus norvegicus rats that were divided into three groups: (1) normal, (2) SCI+nonsecretome, and (3) SCI+secretome (30 μL, intrathecal Th10). Model subacute SCI post-laminectomy was performed in 60 seconds using an aneurysm Yasargil clip with a closing forceps weighing 65 g (150 kdyn). At 35 days post-injury, the specimens were collected, and the immunohistochemicals of IL-10, MMP9, and TGF-β were analyzed. Motor recovery was evaluated based on the BBB scores.The SCI post-laminectomy of rats treated with HNSC secretomes showed improvements in their locomotor recovery based on the BBB scores (p =0.000, mean=18.4) and decreased MMP9 (p =0.015) but had increased the levels of IL-10 (p =0.045) and TGF-β (p =0.01).These results indicate that the factors associated with the HNSC secretomes can mitigate their pathophysiological processes of secondary damage after SCI and improve the locomotor functional outcomes in rats." @default.
• W4313856685 created "2023-01-10" @default.
• W4313856685 creator A5016060784 @default.
• W4313856685 creator A5043899526 @default.
• W4313856685 creator A5061446239 @default.
• W4313856685 creator A5077299589 @default.
• W4313856685 date "2023-04-30" @default.
• W4313856685 modified "2023-09-30" @default.
• W4313856685 title "The Role of Human Neural Stem Cell Secretomes on the Repair of Spinal Cord Injury Post-laminectomy in Rattus norvegicus Through the Analysis of Basso–Beattie–Bresnahan Score Locomotors, Interleukin-10, Matrix Metalloproteinase 9, and Transforming Growth Factor-β" @default.
• W4313856685 cites W2010175048 @default.
• W4313856685 cites W2015116639 @default.
• W4313856685 cites W2047478886 @default.
• W4313856685 cites W2051021959 @default.
• W4313856685 cites W2065262203 @default.
• W4313856685 cites W2075700793 @default.
• W4313856685 cites W2077232718 @default.
• W4313856685 cites W2081552068 @default.
• W4313856685 cites W2085444662 @default.
• W4313856685 cites W2150026933 @default.
• W4313856685 cites W2170645579 @default.
• W4313856685 cites W2222083162 @default.
• W4313856685 cites W2337694833 @default.
• W4313856685 cites W2594400424 @default.
• W4313856685 cites W2608611322 @default.
• W4313856685 cites W2791989026 @default.
• W4313856685 cites W2801559469 @default.
• W4313856685 cites W2888361091 @default.
• W4313856685 cites W2925177128 @default.
• W4313856685 cites W2947219032 @default.
• W4313856685 cites W2955503221 @default.
• W4313856685 cites W2991323130 @default.
• W4313856685 cites W3088704361 @default.
• W4313856685 cites W3127926347 @default.
• W4313856685 cites W3131874286 @default.
• W4313856685 cites W3216510477 @default.
• W4313856685 cites W4205733662 @default.
• W4313856685 doi "https://doi.org/10.31616/asj.2022.0152" @default.
• W4313856685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36625016" @default.
• W4313856685 hasPublicationYear "2023" @default.
• W4313856685 type Work @default.
• W4313856685 citedByCount "0" @default.
• W4313856685 crossrefType "journal-article" @default.
• W4313856685 hasAuthorship W4313856685A5016060784 @default.
• W4313856685 hasAuthorship W4313856685A5043899526 @default.
• W4313856685 hasAuthorship W4313856685A5061446239 @default.
• W4313856685 hasAuthorship W4313856685A5077299589 @default.
• W4313856685 hasBestOaLocation W43138566851 @default.
• W4313856685 hasConcept C118552586 @default.
• W4313856685 hasConcept C141071460 @default.
• W4313856685 hasConcept C2777597760 @default.
• W4313856685 hasConcept C2778334475 @default.
• W4313856685 hasConcept C2780091945 @default.
• W4313856685 hasConcept C2780775167 @default.
• W4313856685 hasConcept C2781306077 @default.
• W4313856685 hasConcept C42219234 @default.
• W4313856685 hasConcept C71924100 @default.
• W4313856685 hasConceptScore W4313856685C118552586 @default.
• W4313856685 hasConceptScore W4313856685C141071460 @default.
• W4313856685 hasConceptScore W4313856685C2777597760 @default.
• W4313856685 hasConceptScore W4313856685C2778334475 @default.
• W4313856685 hasConceptScore W4313856685C2780091945 @default.
• W4313856685 hasConceptScore W4313856685C2780775167 @default.
• W4313856685 hasConceptScore W4313856685C2781306077 @default.
• W4313856685 hasConceptScore W4313856685C42219234 @default.
• W4313856685 hasConceptScore W4313856685C71924100 @default.
• W4313856685 hasIssue "2" @default.
• W4313856685 hasLocation W43138566851 @default.
• W4313856685 hasLocation W43138566852 @default.
• W4313856685 hasOpenAccess W4313856685 @default.
• W4313856685 hasPrimaryLocation W43138566851 @default.
• W4313856685 hasRelatedWork W1830627580 @default.
• W4313856685 hasRelatedWork W189002317 @default.
• W4313856685 hasRelatedWork W2040448232 @default.
• W4313856685 hasRelatedWork W2186674799 @default.
• W4313856685 hasRelatedWork W23466929 @default.
• W4313856685 hasRelatedWork W2400996235 @default.
• W4313856685 hasRelatedWork W2790527496 @default.
• W4313856685 hasRelatedWork W2794867379 @default.
• W4313856685 hasRelatedWork W3166226270 @default.
• W4313856685 hasRelatedWork W4296637788 @default.
• W4313856685 hasVolume "17" @default.
• W4313856685 isParatext "false" @default.
• W4313856685 isRetracted "false" @default.
• W4313856685 workType "article" @default.