FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313856883> ?p ?o ?g. }

• W4313856883 abstract "In biology, regeneration is a mysterious phenomenon that has inspired self-repairing systems, robots, and biobots. It is a collective computational process whereby cells communicate to achieve an anatomical set point and restore original function in regenerated tissue or the whole organism. Despite decades of research, the mechanisms involved in this process are still poorly understood. Likewise, the current algorithms are insufficient to overcome this knowledge barrier and enable advances in regenerative medicine, synthetic biology, and living machines/biobots. We propose a comprehensive conceptual framework for the engine of regeneration with hypotheses for the mechanisms and algorithms of stem cell-mediated regeneration that enables a system like the planarian flatworm to fully restore anatomical (form) and bioelectric (function) homeostasis from any small- or large-scale damage. The framework extends the available regeneration knowledge with novel hypotheses to propose collective intelligent self-repair machines with multi-level feedback neural control systems driven by somatic and stem cells. We computationally implemented the framework to demonstrate the robust recovery of both form and function (anatomical and bioelectric homeostasis) in an in silico worm that, in a simple way, resembles the planarian. In the absence of complete regeneration knowledge, the framework contributes to understanding and generating hypotheses for stem cell mediated form and function regeneration, which may help advance regenerative medicine and synthetic biology. Further, as our framework is a bio-inspired and bio-computing self-repair machine, it may be useful for building self-repair robots/biobots and artificial self-repair systems." @default.
• W4313856883 created "2023-01-10" @default.
• W4313856883 creator A5047200073 @default.
• W4313856883 creator A5091682385 @default.
• W4313856883 date "2023-01-09" @default.
• W4313856883 modified "2023-09-26" @default.
• W4313856883 title "A Comprehensive conceptual and computational dynamics framework for autonomous regeneration of form and function in biological organisms" @default.
• W4313856883 cites W134924349 @default.
• W4313856883 cites W1493365864 @default.
• W4313856883 cites W1553321608 @default.
• W4313856883 cites W1556627432 @default.
• W4313856883 cites W1989859381 @default.
• W4313856883 cites W1994818554 @default.
• W4313856883 cites W1995717740 @default.
• W4313856883 cites W1995892906 @default.
• W4313856883 cites W1998131012 @default.
• W4313856883 cites W2006779040 @default.
• W4313856883 cites W2008879050 @default.
• W4313856883 cites W2014173674 @default.
• W4313856883 cites W2024941696 @default.
• W4313856883 cites W2045097086 @default.
• W4313856883 cites W2052004855 @default.
• W4313856883 cites W2073728900 @default.
• W4313856883 cites W2085992503 @default.
• W4313856883 cites W2088992106 @default.
• W4313856883 cites W2118629908 @default.
• W4313856883 cites W2128084896 @default.
• W4313856883 cites W2146192612 @default.
• W4313856883 cites W2158797557 @default.
• W4313856883 cites W2159008676 @default.
• W4313856883 cites W2164486285 @default.
• W4313856883 cites W2326773736 @default.
• W4313856883 cites W2331336260 @default.
• W4313856883 cites W2401736446 @default.
• W4313856883 cites W2410236777 @default.
• W4313856883 cites W2413902774 @default.
• W4313856883 cites W2571772682 @default.
• W4313856883 cites W2596662456 @default.
• W4313856883 cites W2777149919 @default.
• W4313856883 cites W2784936077 @default.
• W4313856883 cites W2785060806 @default.
• W4313856883 cites W2897726342 @default.
• W4313856883 cites W2900075659 @default.
• W4313856883 cites W2972339623 @default.
• W4313856883 cites W3083593994 @default.
• W4313856883 cites W3198669313 @default.
• W4313856883 cites W4221090176 @default.
• W4313856883 cites W4242946516 @default.
• W4313856883 cites W4285012813 @default.
• W4313856883 doi "https://doi.org/10.1093/pnasnexus/pgac308" @default.
• W4313856883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36845351" @default.
• W4313856883 hasPublicationYear "2023" @default.
• W4313856883 type Work @default.
• W4313856883 citedByCount "0" @default.
• W4313856883 crossrefType "journal-article" @default.
• W4313856883 hasAuthorship W4313856883A5047200073 @default.
• W4313856883 hasAuthorship W4313856883A5091682385 @default.
• W4313856883 hasBestOaLocation W43138568831 @default.
• W4313856883 hasConcept C10854531 @default.
• W4313856883 hasConcept C111472728 @default.
• W4313856883 hasConcept C111919701 @default.
• W4313856883 hasConcept C137858568 @default.
• W4313856883 hasConcept C138885662 @default.
• W4313856883 hasConcept C14036430 @default.
• W4313856883 hasConcept C14224292 @default.
• W4313856883 hasConcept C151730666 @default.
• W4313856883 hasConcept C154945302 @default.
• W4313856883 hasConcept C15744967 @default.
• W4313856883 hasConcept C171056886 @default.
• W4313856883 hasConcept C188147891 @default.
• W4313856883 hasConcept C18903297 @default.
• W4313856883 hasConcept C2775935104 @default.
• W4313856883 hasConcept C2781355164 @default.
• W4313856883 hasConcept C28328180 @default.
• W4313856883 hasConcept C41008148 @default.
• W4313856883 hasConcept C86803240 @default.
• W4313856883 hasConcept C95444343 @default.
• W4313856883 hasConcept C98045186 @default.
• W4313856883 hasConceptScore W4313856883C10854531 @default.
• W4313856883 hasConceptScore W4313856883C111472728 @default.
• W4313856883 hasConceptScore W4313856883C111919701 @default.
• W4313856883 hasConceptScore W4313856883C137858568 @default.
• W4313856883 hasConceptScore W4313856883C138885662 @default.
• W4313856883 hasConceptScore W4313856883C14036430 @default.
• W4313856883 hasConceptScore W4313856883C14224292 @default.
• W4313856883 hasConceptScore W4313856883C151730666 @default.
• W4313856883 hasConceptScore W4313856883C154945302 @default.
• W4313856883 hasConceptScore W4313856883C15744967 @default.
• W4313856883 hasConceptScore W4313856883C171056886 @default.
• W4313856883 hasConceptScore W4313856883C188147891 @default.
• W4313856883 hasConceptScore W4313856883C18903297 @default.
• W4313856883 hasConceptScore W4313856883C2775935104 @default.
• W4313856883 hasConceptScore W4313856883C2781355164 @default.
• W4313856883 hasConceptScore W4313856883C28328180 @default.
• W4313856883 hasConceptScore W4313856883C41008148 @default.
• W4313856883 hasConceptScore W4313856883C86803240 @default.
• W4313856883 hasConceptScore W4313856883C95444343 @default.
• W4313856883 hasConceptScore W4313856883C98045186 @default.
• W4313856883 hasIssue "2" @default.
• W4313856883 hasLocation W43138568831 @default.

• next