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• W4313857520 abstract "Immune checkpoint inhibitors (ICIs) have been widely used in the treatment of lung cancer, but the benefit population is limited and there is a lack of effective predictive markers of efficacy. Tissue-resident memory T cells (TRM) reside in tissues and exert anti-tumor effects by expressing the integrins CD103, CD49a or C-type lectin CD69 and immune checkpoint receptors. TRM expressing programmed cell death 1 (PD-1) is enriched with transcriptional products associated with cytotoxicity and enhances T cell (antigen) receptor (TCR)-mediated cytotoxicity. TRM is a promising biomarker for predicting the efficacy and prognosis of immunotherapy in lung cancer patients. This review will describe the progress of TRM research in lung cancer. .【中文题目：组织驻留记忆T细胞在肺癌中的研究进展】 【中文摘要：免疫检查点抑制剂（immune checkpoint inhibitors, ICIs）虽然广泛用于肺癌的治疗，但获益人群有限，且缺乏有效的疗效预测标志物。组织驻留记忆T细胞（tissue-resident memory T cell, TRM）通过表达整合素CD103、CD49a或C型凝集素CD69和免疫检查点受体，使其在组织中驻留，并发挥抗肿瘤作用。表达程序性死亡受体1（programmed cell death 1, PD-1）的TRM富含与细胞毒性相关的转录产物，增强了T细胞（抗原）受体（T cell receptor, TCR）介导的细胞毒作用。TRM可以预测肺癌患者免疫治疗疗效和预后，是具有前景的生物标志物。本综述将阐述TRM在肺癌中的研究进展。 】 【中文关键词：组织驻留记忆T细胞；肺肿瘤；免疫治疗】." @default.
• W4313857520 created "2023-01-10" @default.
• W4313857520 creator A5088173296 @default.
• W4313857520 creator A5091408445 @default.
• W4313857520 date "2022-12-20" @default.
• W4313857520 modified "2023-09-28" @default.
• W4313857520 title "[Advances in the Study of Tissue-resident Memory T Cells in Lung Cancer]." @default.
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• W4313857520 doi "https://doi.org/10.3779/j.issn.1009-3419.2022.102.49" @default.
• W4313857520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36617472" @default.
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