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- W4313857548 abstract "目的： 探讨间叶性软骨肉瘤（mesenchymal chondrosarcoma，MC）伴横纹肌标志物异常表达的临床病理学特征。 方法： 收集福建省立医院2006年9月至2021年9月2例异常表达横纹肌标志物的MC患者的临床资料、影像学检查、病理特征，荧光原位杂交（FISH）检测NCOA2基因及二代测序检测，并复习相关文献。 结果： 例1女，34岁。例2男，19岁。2例肿瘤发生部位分别为盆腔及前列腺。镜下观察：肿瘤由未分化的小细胞和透明软骨岛构成。小细胞呈圆形、卵圆形、短梭形，排列为片状、巢状，可见血管外皮瘤样结构，2例灶性可见细胞质嗜酸性横纹肌母细胞。免疫表型：SOX9小细胞与软骨阳性，软骨细胞S-100蛋白阳性。2例横纹肌母细胞均MyoD1、Myogenin、结蛋白阳性。FISH检测均未检测到NCOA2基因分离，二代测序检测例1有HEY1-NCOA2融合基因。 结论： MC伴异常表达横纹肌标志物罕见，易误诊，诊断时需综合临床影像、病理、免疫组织化学，必要时需借助分子甚至基因检测以明确诊断。." @default.
- W4313857548 created "2023-01-10" @default.
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- W4313857548 date "2023-01-08" @default.
- W4313857548 modified "2023-09-27" @default.
- W4313857548 title "[Mesenchymal chondrosarcoma with abnormal expression of the skeletal muscle-associated markers: a clinicopathological analysis of two cases]." @default.
- W4313857548 doi "https://doi.org/10.3760/cma.j.cn112151-20221014-00854" @default.
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