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• W4313857583 abstract "Abstract Background It is unknown whether Parkinson's disease (PD) genetic heterogeneity, leading to phenotypic and pathological variability, is also associated with variability in the unique PD electrophysiological signature. Such variability might have practical implications for adaptive deep brain stimulation (DBS). Objective The aim of our work was to study the electrophysiological activity in the subthalamic nucleus (STN) of patients with PD with pathogenic variants in different disease‐causing genes. Methods Electrophysiological data from participants with negative genetic tests were compared with those from GBA , LRRK2 , and PRKN ‐PD. Results We analyzed data from 93 STN trajectories ( GBA ‐PD: 28, LRRK2 ‐PD: 22, PARK ‐PD: 10, idiopathic PD: 33) of 52 individuals who underwent DBS surgery. Characteristics of β oscillatory activity in the dorsolateral motor part of the STN were similar for patients with negative genetic tests and for patients with different forms of monogenic PD. Conclusions The genetic heterogeneity in PD is not associated with electrophysiological differences. Therefore, similar adaptive DBS algorithms would be applicable to genetically heterogeneous patient populations. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society." @default.
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• W4313857583 date "2023-01-09" @default.
• W4313857583 modified "2023-10-14" @default.
• W4313857583 title "The Genetic Etiology of Parkinson's Disease Does Not Robustly Affect Subthalamic Physiology" @default.
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• W4313857583 doi "https://doi.org/10.1002/mds.29310" @default.
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