FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313879947> ?p ?o ?g. }

• W4313879947 endingPage "887" @default.
• W4313879947 startingPage "877" @default.
• W4313879947 abstract "Mesenchymal-epithelial transition factor (MET) has long been considered as the most crucial and promising driver gene in the occurrence and development of non-small cell lung cancer (NSCLC), except for epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), and c-ROS oncogene 1 receptor tyrosine kinase (ROS1). In recent years, therapeutic drugs targeting MET have been continuously developed and applied in clinical practice. First, the curative effect of NSCLC patients with MET exon 14 skipping mutations has been further improved. In addition, when MET amplification occurs after resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs) in patients with advanced EGFR-mutant NSCLC, the combination of MET-TKIs and EGFR-TKIs has brought significant survival benefits and many other advances. This article reviews the treatment progress of NSCLC patients with different types of MET variants under different circumstances, which provides reference for the selection of clinical treatment strategies. .【中文题目：合并MET基因变异的非小细胞肺癌治疗 研究进展】 【中文摘要：间质-上皮细胞转化因子（mesenchymal-epithelial transition factor, MET）长期以来被认为是非小细胞肺癌（non-small cell lung cancer, NSCLC）发生发展过程中除表皮生长因子受体（epidermal growth factor receptor, EGFR）、间变性淋巴瘤激酶（anaplastic lymphoma kinase, ALK）、原癌基因酪氨酸蛋白激酶（c-ros oncogene 1 receptor tyrosine kinase, ROS1）之外最重要和最有前景的驱动基因。近年来，靶向MET的治疗药物不断被研发并应用于临床。首先是合并MET外显子14跳跃突变的NSCLC患者疗效得到进一步的提高。另外，晚期EGFR突变型NSCLC患者EGFR酪氨酸激酶受体抑制剂（EGFR tyrosine kinase inhibitors, EGFR-TKIs）耐药后继发MET扩增时，联合MET-TKIs和EGFR-TKIs的方案带来了明显的生存获益等诸多进展。本文综述了在不同情况下，NSCLC患者合并MET不同变异类型的治疗进展，为临床治疗策略的选择提供参考。 】 【中文关键词：肺肿瘤；MET扩增；跳跃突变；MET酪氨酸激酶抑制剂】." @default.
• W4313879947 created "2023-01-10" @default.
• W4313879947 creator A5006794153 @default.
• W4313879947 creator A5016855459 @default.
• W4313879947 creator A5018393057 @default.
• W4313879947 creator A5052046758 @default.
• W4313879947 creator A5054418300 @default.
• W4313879947 date "2022-12-20" @default.
• W4313879947 modified "2023-10-18" @default.
• W4313879947 title "[Research Progresses in the Treatment of NSCLC with MET Gene Variants: A Riview]." @default.
• W4313879947 cites W1968772718 @default.
• W4313879947 cites W2011138678 @default.
• W4313879947 cites W2018525392 @default.
• W4313879947 cites W2020995084 @default.
• W4313879947 cites W2080432537 @default.
• W4313879947 cites W2177389390 @default.
• W4313879947 cites W2230948985 @default.
• W4313879947 cites W2272081149 @default.
• W4313879947 cites W2466657922 @default.
• W4313879947 cites W2504472048 @default.
• W4313879947 cites W2552674955 @default.
• W4313879947 cites W2587620487 @default.
• W4313879947 cites W2765258454 @default.
• W4313879947 cites W2777461561 @default.
• W4313879947 cites W2791610452 @default.
• W4313879947 cites W2791756039 @default.
• W4313879947 cites W2792821195 @default.
• W4313879947 cites W2800224623 @default.
• W4313879947 cites W2802552316 @default.
• W4313879947 cites W2889307896 @default.
• W4313879947 cites W2889373434 @default.
• W4313879947 cites W2891909134 @default.
• W4313879947 cites W2894066036 @default.
• W4313879947 cites W2896528728 @default.
• W4313879947 cites W2907814135 @default.
• W4313879947 cites W2909285126 @default.
• W4313879947 cites W2944120833 @default.
• W4313879947 cites W2946166987 @default.
• W4313879947 cites W2964617822 @default.
• W4313879947 cites W2969837032 @default.
• W4313879947 cites W2978886033 @default.
• W4313879947 cites W2991151283 @default.
• W4313879947 cites W2995336093 @default.
• W4313879947 cites W2999801017 @default.
• W4313879947 cites W3000668520 @default.
• W4313879947 cites W3001408868 @default.
• W4313879947 cites W3004715000 @default.
• W4313879947 cites W3004905091 @default.
• W4313879947 cites W3015873200 @default.
• W4313879947 cites W3029971508 @default.
• W4313879947 cites W3031018272 @default.
• W4313879947 cites W3033982788 @default.
• W4313879947 cites W3082015854 @default.
• W4313879947 cites W3089110999 @default.
• W4313879947 cites W3173935562 @default.
• W4313879947 cites W3175096644 @default.
• W4313879947 cites W3202106521 @default.
• W4313879947 cites W4200206539 @default.
• W4313879947 cites W4225986451 @default.
• W4313879947 doi "https://doi.org/10.3779/j.issn.1009-3419.2022.101.54" @default.
• W4313879947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36617474" @default.
• W4313879947 hasPublicationYear "2022" @default.
• W4313879947 type Work @default.
• W4313879947 citedByCount "0" @default.
• W4313879947 crossrefType "journal-article" @default.
• W4313879947 hasAuthorship W4313879947A5006794153 @default.
• W4313879947 hasAuthorship W4313879947A5016855459 @default.
• W4313879947 hasAuthorship W4313879947A5018393057 @default.
• W4313879947 hasAuthorship W4313879947A5052046758 @default.
• W4313879947 hasAuthorship W4313879947A5054418300 @default.
• W4313879947 hasConcept C101544691 @default.
• W4313879947 hasConcept C117643217 @default.
• W4313879947 hasConcept C121608353 @default.
• W4313879947 hasConcept C126322002 @default.
• W4313879947 hasConcept C143998085 @default.
• W4313879947 hasConcept C170493617 @default.
• W4313879947 hasConcept C2775999482 @default.
• W4313879947 hasConcept C2776232967 @default.
• W4313879947 hasConcept C2776256026 @default.
• W4313879947 hasConcept C2778087573 @default.
• W4313879947 hasConcept C2779422266 @default.
• W4313879947 hasConcept C2779438470 @default.
• W4313879947 hasConcept C2781182431 @default.
• W4313879947 hasConcept C42362537 @default.
• W4313879947 hasConcept C502942594 @default.
• W4313879947 hasConcept C71924100 @default.
• W4313879947 hasConceptScore W4313879947C101544691 @default.
• W4313879947 hasConceptScore W4313879947C117643217 @default.
• W4313879947 hasConceptScore W4313879947C121608353 @default.
• W4313879947 hasConceptScore W4313879947C126322002 @default.
• W4313879947 hasConceptScore W4313879947C143998085 @default.
• W4313879947 hasConceptScore W4313879947C170493617 @default.
• W4313879947 hasConceptScore W4313879947C2775999482 @default.
• W4313879947 hasConceptScore W4313879947C2776232967 @default.
• W4313879947 hasConceptScore W4313879947C2776256026 @default.
• W4313879947 hasConceptScore W4313879947C2778087573 @default.
• W4313879947 hasConceptScore W4313879947C2779422266 @default.
• W4313879947 hasConceptScore W4313879947C2779438470 @default.

• next