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- W4313880164 endingPage "263" @default.
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- W4313880164 abstract "Abstract The evolution of aging requires mutations with late-life deleterious effects. Classic theories assume these mutations either have neutral (mutation accumulation) or beneficial (antagonistic pleiotropy) effects early in life, but it is also possible that they start out as mildly harmful and gradually become more deleterious with age. Despite a wealth of studies on the genetics of aging, we still have a poor understanding of how common mutations with age-specific effects are and what aging theory they support. To advance our knowledge on this topic, we measure a set of genomic deletions for their heterozygous effects on juvenile performance, fecundity at 3 ages, and adult survival. Most deletions have age-specific effects, and these are commonly harmful late in life. Many of the deletions assayed here would thus contribute to aging if present in a population. Taking only age-specific fecundity into account, some deletions support antagonistic pleiotropy, but the majority of them better fit a scenario where their negative effects on fecundity become progressively worse with age. Most deletions have a negative effect on juvenile performance, a fact that strengthens the conclusion that deletions primarily contribute to aging through negative effects that amplify with age." @default.
- W4313880164 created "2023-01-10" @default.
- W4313880164 creator A5006441285 @default.
- W4313880164 creator A5015662173 @default.
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- W4313880164 creator A5056250500 @default.
- W4313880164 creator A5083860740 @default.
- W4313880164 creator A5085285699 @default.
- W4313880164 date "2022-12-08" @default.
- W4313880164 modified "2023-10-18" @default.
- W4313880164 title "Age-specific effects of deletions: implications for aging theories" @default.
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