FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313886799> ?p ?o ?g. }

• W4313886799 endingPage "161504" @default.
• W4313886799 startingPage "161504" @default.
• W4313886799 abstract "In utero perfluoroalkyl substances (PFAS) exposure has been associated with childhood adiposity, but the mechanisms are poorly known.To investigate the potential mediating role of neonatal metabolites in the relationship between prenatal PFAS exposure and childhood adiposity trajectories in the first four years of life.We analyzed the data for 1671 mother-child pairs from the Shanghai Birth Cohort study. We included those with PFAS exposure information in early pregnancy, neonatal metabolites data and at least three child anthropometric measurements at 6, 12, 24 and/or 48 months. Body mass index (BMI) z-score trajectories were identified using latent class growth mixture modeling. The associations between PFAS concentrations and trajectory classes were assessed using multinomial logistic regression. Screening and penalization-based selection was used to identify neonatal amino acids and acylcarnitines with significant mediation effects.Three BMI z-score trajectories in early childhood were identified: a persistent increase trajectory (Class 1, 2.2 %), a stable trajectory (Class 2, 66 %), and a transient increase trajectory (Class 3, 32 %). Increased odds of being in Class 1 were observed in association with one log-unit increase in concentrations of perfluorooctane sulfonate (odds ratio [OR], 1.76 [95 % CI, 0.96-3.23], Class 2 as reference; OR, 2.36 [95 % CI, 1.27-4.40], Class 3 as reference), perfluorononanoic acid (OR, 1.90 [95 % CI, 0.97-3.72], Class 2 as reference; OR, 2.23 [95 % CI, 1.12-4.42], Class 3 as reference) and perfluorodecanoic acid (OR, 1.95 [95 % CI, 1.12-3.38], Class 2 as reference; OR, 2.14 [95 % CI, 1.22-3.76], Class 3 as reference). The effect of prenatal PFAS exposure on being in Class 1 was significantly but partly mediated by octanoylcarnitine (2.64 % for perfluorononanoic acid and 3.70 % for sum of 10 PFAS).In utero PFAS exposure is a risk factor for persistent growth in BMI z-score in early childhood. The alteration of neonatal acylcarnitines suggests a potential molecular pathway." @default.
• W4313886799 created "2023-01-10" @default.
• W4313886799 creator A5005124051 @default.
• W4313886799 creator A5010446119 @default.
• W4313886799 creator A5020162825 @default.
• W4313886799 creator A5021996035 @default.
• W4313886799 creator A5037458498 @default.
• W4313886799 creator A5042381238 @default.
• W4313886799 creator A5068290128 @default.
• W4313886799 creator A5072334257 @default.
• W4313886799 creator A5077716269 @default.
• W4313886799 creator A5086936559 @default.
• W4313886799 date "2023-04-01" @default.
• W4313886799 modified "2023-10-17" @default.
• W4313886799 title "In utero exposure to perfluoroalkyl substances and early childhood BMI trajectories: A mediation analysis with neonatal metabolic profiles" @default.
• W4313886799 cites W157502360 @default.
• W4313886799 cites W1623684340 @default.
• W4313886799 cites W1764778685 @default.
• W4313886799 cites W1988730238 @default.
• W4313886799 cites W2016709601 @default.
• W4313886799 cites W2016741073 @default.
• W4313886799 cites W2037933403 @default.
• W4313886799 cites W2039944970 @default.
• W4313886799 cites W2040834378 @default.
• W4313886799 cites W2060491988 @default.
• W4313886799 cites W2093568744 @default.
• W4313886799 cites W2103862158 @default.
• W4313886799 cites W2104622204 @default.
• W4313886799 cites W2107228744 @default.
• W4313886799 cites W2113949150 @default.
• W4313886799 cites W2140393170 @default.
• W4313886799 cites W2152028368 @default.
• W4313886799 cites W2155128881 @default.
• W4313886799 cites W2190043075 @default.
• W4313886799 cites W2328938627 @default.
• W4313886799 cites W2332969818 @default.
• W4313886799 cites W2462251147 @default.
• W4313886799 cites W2474105078 @default.
• W4313886799 cites W2524167689 @default.
• W4313886799 cites W2556805998 @default.
• W4313886799 cites W2604805987 @default.
• W4313886799 cites W2620619966 @default.
• W4313886799 cites W2724290332 @default.
• W4313886799 cites W2733138053 @default.
• W4313886799 cites W2735334973 @default.
• W4313886799 cites W2742090859 @default.
• W4313886799 cites W2750612244 @default.
• W4313886799 cites W2759874643 @default.
• W4313886799 cites W2777929193 @default.
• W4313886799 cites W2790439914 @default.
• W4313886799 cites W2791444690 @default.
• W4313886799 cites W2794722104 @default.
• W4313886799 cites W2796153381 @default.
• W4313886799 cites W2883261499 @default.
• W4313886799 cites W2891083728 @default.
• W4313886799 cites W2892510821 @default.
• W4313886799 cites W2895903553 @default.
• W4313886799 cites W2899719560 @default.
• W4313886799 cites W2899778004 @default.
• W4313886799 cites W2908760437 @default.
• W4313886799 cites W2909684602 @default.
• W4313886799 cites W2910919969 @default.
• W4313886799 cites W2914955705 @default.
• W4313886799 cites W2918371302 @default.
• W4313886799 cites W2923837171 @default.
• W4313886799 cites W2926379949 @default.
• W4313886799 cites W2936569839 @default.
• W4313886799 cites W2939542244 @default.
• W4313886799 cites W2943597663 @default.
• W4313886799 cites W2955103901 @default.
• W4313886799 cites W2968923403 @default.
• W4313886799 cites W3001510540 @default.
• W4313886799 cites W3005956609 @default.
• W4313886799 cites W3015220639 @default.
• W4313886799 cites W3039321696 @default.
• W4313886799 cites W3040597861 @default.
• W4313886799 cites W3048159934 @default.
• W4313886799 cites W3072320092 @default.
• W4313886799 cites W3083268731 @default.
• W4313886799 cites W3098804274 @default.
• W4313886799 cites W3099995528 @default.
• W4313886799 cites W3123883264 @default.
• W4313886799 cites W3135396002 @default.
• W4313886799 cites W3161586133 @default.
• W4313886799 cites W3162977853 @default.
• W4313886799 cites W3163984629 @default.
• W4313886799 cites W3166723582 @default.
• W4313886799 cites W3178581156 @default.
• W4313886799 cites W3210620488 @default.
• W4313886799 cites W3210626271 @default.
• W4313886799 cites W3216627836 @default.
• W4313886799 cites W3217045809 @default.
• W4313886799 cites W4214507826 @default.
• W4313886799 cites W4221099521 @default.
• W4313886799 cites W4242106902 @default.
• W4313886799 cites W4282963565 @default.
• W4313886799 cites W4286111276 @default.
• W4313886799 cites W4295996166 @default.

• next