FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313887095> ?p ?o ?g. }

• W4313887095 abstract "Social disturbance in interpersonal relationships is the primary source of stress in humans. Spexin (SPX, SPX1a in cichlid), an evolutionarily conserved neuropeptide with diverse physiological functions, is up-regulated in the brain during chronic social defeat stress in teleost. On the other hand, repeated exposure to social stress can lead to dysregulation of the monoaminergic system and increase the vulnerability of developing depression. Since dysfunction of the serotonin (5-hydroxytryptamine, 5-HT) system is associated with social stress and the pathophysiology of depression, the present study investigated the regulatory relationship between the central 5-HT system and SPX1a in the male teleost, Nile tilapia (Oreochromis niloticus). To identify stress factors that regulate SPX1a gene expression, cortisol, dexamethasone (DEX), and 5-HT were used to treat tilapia brain primary cultures. Our study shows cortisol and DEX treatment had no effect on SPX1a gene expression, but SPX1a gene expression was down-regulated following 5-HT treatment. Anatomical localization showed a close association between 5-HT immunoreactive projections and SPX1a neurons in the semicircular torus. In addition, 5-HT receptors (5-HT2B) were expressed in SPX1a neurons. SPX1a immunoreactive neurons and SPX1a gene expression were significantly increased in socially defeated tilapia. On the other hand, citalopram (antidepressant, 5-HT antagonist) treatment to socially defeated tilapia normalized SPX1a gene expression to control levels. Taken together, the present study shows that 5-HT is an upstream regulator of SPX1a and that the inhibited 5-HT activates SPX1a during social defeat." @default.
• W4313887095 created "2023-01-10" @default.
• W4313887095 creator A5016177265 @default.
• W4313887095 creator A5084852487 @default.
• W4313887095 creator A5085977370 @default.
• W4313887095 date "2023-01-09" @default.
• W4313887095 modified "2023-10-03" @default.
• W4313887095 title "Social stress-induced serotonin dysfunction activates spexin in male Nile tilapia ( <i>Oreochromis Niloticus</i> )" @default.
• W4313887095 cites W1209650978 @default.
• W4313887095 cites W121566136 @default.
• W4313887095 cites W1887882764 @default.
• W4313887095 cites W1898408664 @default.
• W4313887095 cites W1951492130 @default.
• W4313887095 cites W1960686950 @default.
• W4313887095 cites W1971793821 @default.
• W4313887095 cites W1981508307 @default.
• W4313887095 cites W1985336737 @default.
• W4313887095 cites W2000827819 @default.
• W4313887095 cites W2007297913 @default.
• W4313887095 cites W2013914344 @default.
• W4313887095 cites W2017154881 @default.
• W4313887095 cites W2020147283 @default.
• W4313887095 cites W2024628648 @default.
• W4313887095 cites W2026453375 @default.
• W4313887095 cites W2027205830 @default.
• W4313887095 cites W2036142408 @default.
• W4313887095 cites W2040515829 @default.
• W4313887095 cites W2054210408 @default.
• W4313887095 cites W2089432209 @default.
• W4313887095 cites W2110955276 @default.
• W4313887095 cites W2113212103 @default.
• W4313887095 cites W2113418300 @default.
• W4313887095 cites W2116629441 @default.
• W4313887095 cites W2118659222 @default.
• W4313887095 cites W2121608010 @default.
• W4313887095 cites W2127722821 @default.
• W4313887095 cites W2128164692 @default.
• W4313887095 cites W2139368987 @default.
• W4313887095 cites W2145079751 @default.
• W4313887095 cites W2162045347 @default.
• W4313887095 cites W2164024874 @default.
• W4313887095 cites W2275181360 @default.
• W4313887095 cites W2320898978 @default.
• W4313887095 cites W2507771067 @default.
• W4313887095 cites W2516314843 @default.
• W4313887095 cites W2523250431 @default.
• W4313887095 cites W2766821246 @default.
• W4313887095 cites W2792202067 @default.
• W4313887095 cites W2890507604 @default.
• W4313887095 cites W2904847165 @default.
• W4313887095 cites W2908981197 @default.
• W4313887095 cites W2925143433 @default.
• W4313887095 cites W2937344378 @default.
• W4313887095 cites W2953014353 @default.
• W4313887095 cites W2965264429 @default.
• W4313887095 cites W3008406160 @default.
• W4313887095 cites W3008749444 @default.
• W4313887095 cites W3016330930 @default.
• W4313887095 cites W3020936364 @default.
• W4313887095 cites W3046717383 @default.
• W4313887095 cites W3109131936 @default.
• W4313887095 cites W3122348907 @default.
• W4313887095 cites W3128901610 @default.
• W4313887095 doi "https://doi.org/10.1073/pnas.2117547120" @default.
• W4313887095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36623187" @default.
• W4313887095 hasPublicationYear "2023" @default.
• W4313887095 type Work @default.
• W4313887095 citedByCount "3" @default.
• W4313887095 countsByYear W43138870952023 @default.
• W4313887095 crossrefType "journal-article" @default.
• W4313887095 hasAuthorship W4313887095A5016177265 @default.
• W4313887095 hasAuthorship W4313887095A5084852487 @default.
• W4313887095 hasAuthorship W4313887095A5085977370 @default.
• W4313887095 hasBestOaLocation W43138870951 @default.
• W4313887095 hasConcept C126322002 @default.
• W4313887095 hasConcept C134018914 @default.
• W4313887095 hasConcept C170493617 @default.
• W4313887095 hasConcept C2775864247 @default.
• W4313887095 hasConcept C2778658382 @default.
• W4313887095 hasConcept C2779177272 @default.
• W4313887095 hasConcept C2779286987 @default.
• W4313887095 hasConcept C2779760398 @default.
• W4313887095 hasConcept C2780129523 @default.
• W4313887095 hasConcept C2780841215 @default.
• W4313887095 hasConcept C2781161787 @default.
• W4313887095 hasConcept C2909208804 @default.
• W4313887095 hasConcept C42251903 @default.
• W4313887095 hasConcept C505870484 @default.
• W4313887095 hasConcept C54355233 @default.
• W4313887095 hasConcept C59493245 @default.
• W4313887095 hasConcept C71924100 @default.
• W4313887095 hasConcept C86803240 @default.
• W4313887095 hasConceptScore W4313887095C126322002 @default.
• W4313887095 hasConceptScore W4313887095C134018914 @default.
• W4313887095 hasConceptScore W4313887095C170493617 @default.
• W4313887095 hasConceptScore W4313887095C2775864247 @default.
• W4313887095 hasConceptScore W4313887095C2778658382 @default.
• W4313887095 hasConceptScore W4313887095C2779177272 @default.
• W4313887095 hasConceptScore W4313887095C2779286987 @default.
• W4313887095 hasConceptScore W4313887095C2779760398 @default.

• next