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- W4313887250 endingPage "94" @default.
- W4313887250 startingPage "83" @default.
- W4313887250 abstract "Aging is characterized by the progressive decline of biological integrity and its compensatory mechanisms as well as immunological dysregulation. This goes along with an increasing risk of frailty and disease. Against this background, we here specifically focus on the aging of the human liver. For the first time, we shed light on the intertwining evolutionary underpinnings of the liver's declining regenerative capacity, the phenomenon of inflammaging, and the biotransformation capacity in the process of aging. In addition, we discuss how aging influences the risk for developing nonalcoholic fatty liver disease, hepatocellular carcinoma, and/or autoimmune hepatitis, and we describe chronic diseases as accelerators of biological aging.Altern ist gekennzeichnet durch die progrediente Abnahme der biologischen Integrität und ihrer kompensatorischen Mechanismen sowie immunologische Dysregulation. Dies geht mit einem zunehmenden Risiko für Gebrechlichkeit und Krankheit einher. Vor diesem Hintergrund fokussieren wir auf die Alterung der menschlichen Leber. Dabei beleuchten wir erstmals die ineinandergreifenden evolutiven Fundamente der abnehmenden Leberregenerationsfähigkeit, des Inflammaging-Phänomens und der Biotransformationskapazität im Alterungsprozess. Zudem diskutieren wir den Einfluss des Alterns auf das Risko, eine nichtalkoholische Fettlebererkrankung, ein Hepatozelluläres Karzinom und/oder eine Autoimmunhepatitis zu entwickeln, und wir beschreiben chronische Erkrankungen als Beschleuniger des biologischen Alterns." @default.
- W4313887250 created "2023-01-10" @default.
- W4313887250 creator A5038880256 @default.
- W4313887250 creator A5063115477 @default.
- W4313887250 creator A5074283299 @default.
- W4313887250 date "2023-01-01" @default.
- W4313887250 modified "2023-09-30" @default.
- W4313887250 title "The Aging Human Liver: The Weal and Woe of Evolutionary Legacy" @default.
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