FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313887568> ?p ?o ?g. }

• W4313887568 endingPage "114319" @default.
• W4313887568 startingPage "114319" @default.
• W4313887568 abstract "It is of particular interest the potential of cannabinoid and angiotensin receptors as targets in the therapy of Parkinson's disease (PD). While endocannabinoids are neuromodulators that act through the CB1 and CB2 cannabinoid receptors, the renin angiotensin-system is relevant for regulation of the correct functioning of several brain circuits. Resonance energy transfer assays in a heterologous system showed that the CB1 receptor (CB1R) can directly interact with the angiotensin AT2 receptor (AT2R). Coactivation of the two receptors results in increased Gi-signaling. The AT2-CB1 receptor heteromer imprint consists of a blockade of AT2R-mediated signaling by rimonabant, a CB1R antagonist. Interestingly, the heteromer imprint, discovered in the heterologous system, was also found in primary striatal neurons thus demonstrating the expression of the heteromer in these cells. In situ proximity ligation assays confirmed the occurrence of AT2-CB1 receptor heteromers in striatal neurons. In addition, increased expression of the AT2-CB1 receptor heteromeric complexes was detected in the striatum of a rodent PD model consisting of rats hemilesioned using 6-hydroxydopamine. Expression of the heteromer was upregulated in the striatum of lesioned animals and, also, of lesioned animals that upon levodopa treatment became dyskinetic. In contrast, there was no upregulation in the striatum of lesioned rats that did not become dyskinetic upon chronic levodopa treatment. The results suggest that therapeutic developments focused on the CB1R should consider that this receptor can interact with the AT2R, which in the CNS is involved in mechanisms related to addictive behaviors and to neurodegenerative and neuroinflammatory diseases." @default.
• W4313887568 created "2023-01-10" @default.
• W4313887568 creator A5012781549 @default.
• W4313887568 creator A5014576744 @default.
• W4313887568 creator A5029995676 @default.
• W4313887568 creator A5032276487 @default.
• W4313887568 creator A5039996371 @default.
• W4313887568 creator A5043879414 @default.
• W4313887568 creator A5048432018 @default.
• W4313887568 creator A5066168499 @default.
• W4313887568 creator A5091387530 @default.
• W4313887568 date "2023-04-01" @default.
• W4313887568 modified "2023-10-06" @default.
• W4313887568 title "The cannabinoid CB1 receptor interacts with the angiotensin AT2 receptor. Overexpression of AT2-CB1 receptor heteromers in the striatum of 6-hydroxydopamine hemilesioned rats" @default.
• W4313887568 cites W1146102393 @default.
• W4313887568 cites W1538480909 @default.
• W4313887568 cites W1572978394 @default.
• W4313887568 cites W1821373092 @default.
• W4313887568 cites W1963852906 @default.
• W4313887568 cites W1964734416 @default.
• W4313887568 cites W1966260988 @default.
• W4313887568 cites W1972725492 @default.
• W4313887568 cites W1985395422 @default.
• W4313887568 cites W1987936460 @default.
• W4313887568 cites W2013094714 @default.
• W4313887568 cites W2031078617 @default.
• W4313887568 cites W2033091119 @default.
• W4313887568 cites W2034750064 @default.
• W4313887568 cites W2040250147 @default.
• W4313887568 cites W2043139305 @default.
• W4313887568 cites W2048079557 @default.
• W4313887568 cites W2048770882 @default.
• W4313887568 cites W2050320031 @default.
• W4313887568 cites W2067724628 @default.
• W4313887568 cites W2075850029 @default.
• W4313887568 cites W2081183340 @default.
• W4313887568 cites W2086889423 @default.
• W4313887568 cites W2096882342 @default.
• W4313887568 cites W2098731920 @default.
• W4313887568 cites W2110398562 @default.
• W4313887568 cites W2112755850 @default.
• W4313887568 cites W2113545613 @default.
• W4313887568 cites W2116053957 @default.
• W4313887568 cites W2142789746 @default.
• W4313887568 cites W2150109464 @default.
• W4313887568 cites W2155848437 @default.
• W4313887568 cites W2162947781 @default.
• W4313887568 cites W2328117593 @default.
• W4313887568 cites W2470961493 @default.
• W4313887568 cites W2584031879 @default.
• W4313887568 cites W2588810449 @default.
• W4313887568 cites W2625733228 @default.
• W4313887568 cites W2749370877 @default.
• W4313887568 cites W2767504971 @default.
• W4313887568 cites W2791138970 @default.
• W4313887568 cites W2864321857 @default.
• W4313887568 cites W2888972388 @default.
• W4313887568 cites W2899178445 @default.
• W4313887568 cites W2911494789 @default.
• W4313887568 cites W2914319179 @default.
• W4313887568 cites W2925027725 @default.
• W4313887568 cites W2981887684 @default.
• W4313887568 cites W2990795452 @default.
• W4313887568 cites W2994975907 @default.
• W4313887568 cites W3022458398 @default.
• W4313887568 cites W3044090000 @default.
• W4313887568 cites W3049733825 @default.
• W4313887568 cites W3090683200 @default.
• W4313887568 cites W3092606158 @default.
• W4313887568 cites W3123016448 @default.
• W4313887568 cites W3130019407 @default.
• W4313887568 cites W3137092013 @default.
• W4313887568 cites W3210282186 @default.
• W4313887568 cites W3216234314 @default.
• W4313887568 cites W4214893974 @default.
• W4313887568 cites W4225131055 @default.
• W4313887568 cites W4229054631 @default.
• W4313887568 cites W4250266299 @default.
• W4313887568 cites W4280583713 @default.
• W4313887568 cites W4283688509 @default.
• W4313887568 cites W4297817255 @default.
• W4313887568 cites W4307724004 @default.
• W4313887568 cites W4308937496 @default.
• W4313887568 cites W4309728518 @default.
• W4313887568 cites W4310733198 @default.
• W4313887568 cites W84093033 @default.
• W4313887568 doi "https://doi.org/10.1016/j.expneurol.2023.114319" @default.
• W4313887568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36632949" @default.
• W4313887568 hasPublicationYear "2023" @default.
• W4313887568 type Work @default.
• W4313887568 citedByCount "2" @default.
• W4313887568 countsByYear W43138875682023 @default.
• W4313887568 crossrefType "journal-article" @default.
• W4313887568 hasAuthorship W4313887568A5012781549 @default.
• W4313887568 hasAuthorship W4313887568A5014576744 @default.
• W4313887568 hasAuthorship W4313887568A5029995676 @default.
• W4313887568 hasAuthorship W4313887568A5032276487 @default.
• W4313887568 hasAuthorship W4313887568A5039996371 @default.

• next