FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313887690> ?p ?o ?g. }

• W4313887690 endingPage "93" @default.
• W4313887690 startingPage "87" @default.
• W4313887690 abstract "The cardiotoxicity induced by human epidermal growth factor receptor-2 (HER-2) inhibitors in patients with breast cancer has been reported widely. However, these data sources were largely limited to fewer patients in clinical trials and case reports, lacking more comprehensive analysis from real-world data.The cases diagnosed with breast cancer from January 2004 to December 2021 were extracted from the FDA adverse event database and further divided into 3 groups (the HER-2 inhibitor group, the positive control group, and the control group). The association between HER-2 inhibitors and cardiovascular adverse events was evaluated using the reporting odds ratio (ROR), a disproportionality method.A total of 167,639 breast cancer patients were included, including 18,615 cases in the HER-2 inhibitor drug group, 2568 cases in the positive control group, and 146,456 cases in the control group. A total of 2529 cases (13.5%) treated with HER-2 inhibitors experienced cardiovascular adverse events, mainly reported by health professionals (81.5%). The disproportionality analysis showed that cardiomyopathy was observed in all HER-2 inhibitors except trastuzumab deruxtecan. Trastuzumab-related CVAEs were most frequently reported (N =2075), and the median time was 80.50 days (IQR: 8.00 to 206.75 days).Based on real-world data analysis, our study demonstrated a significant association between HER-2 inhibitors and cardiovascular toxicity. Cardiac function in patients with breast cancer should be monitored early during anti-HER therapy, especially within six months." @default.
• W4313887690 created "2023-01-10" @default.
• W4313887690 creator A5007428411 @default.
• W4313887690 creator A5017942789 @default.
• W4313887690 creator A5036985869 @default.
• W4313887690 creator A5050260933 @default.
• W4313887690 creator A5050784237 @default.
• W4313887690 creator A5063253432 @default.
• W4313887690 creator A5081207491 @default.
• W4313887690 date "2023-03-01" @default.
• W4313887690 modified "2023-09-28" @default.
• W4313887690 title "Cardiotoxicity with human epidermal growth factor receptor-2 inhibitors in breast cancer: Disproportionality analysis of the FDA adverse event reporting system" @default.
• W4313887690 cites W2006236530 @default.
• W4313887690 cites W2015038969 @default.
• W4313887690 cites W2029542561 @default.
• W4313887690 cites W2077534178 @default.
• W4313887690 cites W2083296039 @default.
• W4313887690 cites W2083386761 @default.
• W4313887690 cites W2083486298 @default.
• W4313887690 cites W2101299592 @default.
• W4313887690 cites W2106130415 @default.
• W4313887690 cites W2126727347 @default.
• W4313887690 cites W2149485684 @default.
• W4313887690 cites W2159967578 @default.
• W4313887690 cites W2170133058 @default.
• W4313887690 cites W2215245712 @default.
• W4313887690 cites W2307330081 @default.
• W4313887690 cites W2318605753 @default.
• W4313887690 cites W2322068229 @default.
• W4313887690 cites W2560560709 @default.
• W4313887690 cites W2735589903 @default.
• W4313887690 cites W2953012138 @default.
• W4313887690 cites W2981605650 @default.
• W4313887690 cites W2998958074 @default.
• W4313887690 cites W3118711353 @default.
• W4313887690 cites W3128646645 @default.
• W4313887690 cites W3136244698 @default.
• W4313887690 cites W3171709380 @default.
• W4313887690 cites W3200163232 @default.
• W4313887690 cites W3204395813 @default.
• W4313887690 cites W4236631640 @default.
• W4313887690 cites W4245806444 @default.
• W4313887690 cites W4281640394 @default.
• W4313887690 cites W4283393217 @default.
• W4313887690 cites W980260691 @default.
• W4313887690 doi "https://doi.org/10.1016/j.ijcard.2022.12.043" @default.
• W4313887690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36634822" @default.
• W4313887690 hasPublicationYear "2023" @default.
• W4313887690 type Work @default.
• W4313887690 citedByCount "1" @default.
• W4313887690 countsByYear W43138876902023 @default.
• W4313887690 crossrefType "journal-article" @default.
• W4313887690 hasAuthorship W4313887690A5007428411 @default.
• W4313887690 hasAuthorship W4313887690A5017942789 @default.
• W4313887690 hasAuthorship W4313887690A5036985869 @default.
• W4313887690 hasAuthorship W4313887690A5050260933 @default.
• W4313887690 hasAuthorship W4313887690A5050784237 @default.
• W4313887690 hasAuthorship W4313887690A5063253432 @default.
• W4313887690 hasAuthorship W4313887690A5081207491 @default.
• W4313887690 hasConcept C121608353 @default.
• W4313887690 hasConcept C126322002 @default.
• W4313887690 hasConcept C143998085 @default.
• W4313887690 hasConcept C156957248 @default.
• W4313887690 hasConcept C197934379 @default.
• W4313887690 hasConcept C2776694085 @default.
• W4313887690 hasConcept C2777105317 @default.
• W4313887690 hasConcept C2778233292 @default.
• W4313887690 hasConcept C2779786085 @default.
• W4313887690 hasConcept C530470458 @default.
• W4313887690 hasConcept C71924100 @default.
• W4313887690 hasConcept C98274493 @default.
• W4313887690 hasConceptScore W4313887690C121608353 @default.
• W4313887690 hasConceptScore W4313887690C126322002 @default.
• W4313887690 hasConceptScore W4313887690C143998085 @default.
• W4313887690 hasConceptScore W4313887690C156957248 @default.
• W4313887690 hasConceptScore W4313887690C197934379 @default.
• W4313887690 hasConceptScore W4313887690C2776694085 @default.
• W4313887690 hasConceptScore W4313887690C2777105317 @default.
• W4313887690 hasConceptScore W4313887690C2778233292 @default.
• W4313887690 hasConceptScore W4313887690C2779786085 @default.
• W4313887690 hasConceptScore W4313887690C530470458 @default.
• W4313887690 hasConceptScore W4313887690C71924100 @default.
• W4313887690 hasConceptScore W4313887690C98274493 @default.
• W4313887690 hasFunder F4320322990 @default.
• W4313887690 hasFunder F4320333335 @default.
• W4313887690 hasFunder F4320336042 @default.
• W4313887690 hasLocation W43138876901 @default.
• W4313887690 hasLocation W43138876902 @default.
• W4313887690 hasOpenAccess W4313887690 @default.
• W4313887690 hasPrimaryLocation W43138876901 @default.
• W4313887690 hasRelatedWork W1992303132 @default.
• W4313887690 hasRelatedWork W202728438 @default.
• W4313887690 hasRelatedWork W2367874297 @default.
• W4313887690 hasRelatedWork W2790097794 @default.
• W4313887690 hasRelatedWork W2918970421 @default.
• W4313887690 hasRelatedWork W2934076975 @default.
• W4313887690 hasRelatedWork W2955324663 @default.
• W4313887690 hasRelatedWork W4225390758 @default.

• next