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- W4313887854 abstract "(Cancer Cell 40, 1600–1618; December 12, 2022) In this article, the authors demonstrated that antiangiogenic immunotherapies differentiate postcapillary venules into high-endothelial venules (HEVs) that foster permissive TCF1+ T lymphocyte niches. In the introduction, they mistakenly stated that HEVs express L-Selectin/CD62L, while HEVs express the sulphated and glycosylated ligands for L-Selectin/CD62L. The original article has been corrected online. The authors regret this error and apologize for any confusion this might have caused. Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loopHua et al.Cancer CellNovember 23, 2022In BriefHua et al. reveal that effective antiangiogenic immunotherapy differentiates postcapillary venules into high-endothelial venules (HEVs) by lymphotoxin beta receptor activation emanating from CD8 T and NK cell-derived signals. TU-HEVs establish perivascular niches in which TCF1+PD1+ lymphocytes expand and produce cytotoxic PD1+TIM3+ lymphocytes that may facilitate anti-tumoral immunity. Full-Text PDF Open Access" @default.
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- W4313887854 date "2023-01-01" @default.
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- W4313887854 title "Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop" @default.
- W4313887854 doi "https://doi.org/10.1016/j.ccell.2022.12.006" @default.
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