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- W4313887934 endingPage "279" @default.
- W4313887934 startingPage "255" @default.
- W4313887934 abstract "Hematopoietic stem cells (HSCs) are multipotent stem cells that give rise to all cells of the blood and most immune cells. Due to their capacity for unlimited self-renewal, long-term HSCs replenish the blood and immune cells of an organism throughout its life. HSC development, maintenance, and differentiation are all tightly regulated by cell signaling pathways, including the Wnt pathway. Wnt signaling is initiated extracellularly by secreted ligands which bind to cell surface receptors and give rise to several different downstream signaling cascades. These are classically categorized either β-catenin dependent (BCD) or β-catenin independent (BCI) signaling, depending on their reliance on the β-catenin transcriptional activator. HSC development, homeostasis, and differentiation is influenced by both BCD and BCI, with a high degree of sensitivity to the timing and dosage of Wnt signaling. Importantly, dysregulated Wnt signals can result in hematological malignancies such as leukemia, lymphoma, and myeloma. Here, we review how Wnt signaling impacts HSCs during development and in disease." @default.
- W4313887934 created "2023-01-10" @default.
- W4313887934 creator A5018871195 @default.
- W4313887934 creator A5021259867 @default.
- W4313887934 creator A5027057361 @default.
- W4313887934 creator A5075290884 @default.
- W4313887934 date "2023-01-01" @default.
- W4313887934 modified "2023-09-30" @default.
- W4313887934 title "Wnt regulation of hematopoietic stem cell development and disease" @default.
- W4313887934 cites W129269179 @default.
- W4313887934 cites W1412788771 @default.
- W4313887934 cites W1501304042 @default.
- W4313887934 cites W1518105110 @default.
- W4313887934 cites W1644646680 @default.
- W4313887934 cites W1751935826 @default.
- W4313887934 cites W180685312 @default.
- W4313887934 cites W1874864331 @default.
- W4313887934 cites W1877572006 @default.
- W4313887934 cites W1964907478 @default.
- W4313887934 cites W1969071453 @default.
- W4313887934 cites W1969942711 @default.
- W4313887934 cites W1971352272 @default.
- W4313887934 cites W1972169216 @default.
- W4313887934 cites W1976799970 @default.
- W4313887934 cites W1977070131 @default.
- W4313887934 cites W1977297606 @default.
- W4313887934 cites W1977701274 @default.
- W4313887934 cites W1978768129 @default.
- W4313887934 cites W1978881608 @default.
- W4313887934 cites W1982891640 @default.
- W4313887934 cites W1983755269 @default.
- W4313887934 cites W1988146415 @default.
- W4313887934 cites W1989456936 @default.
- W4313887934 cites W1992166041 @default.
- W4313887934 cites W1994899810 @default.
- W4313887934 cites W1995940184 @default.
- W4313887934 cites W1998854709 @default.
- W4313887934 cites W2000293457 @default.
- W4313887934 cites W2000572346 @default.
- W4313887934 cites W2001566685 @default.
- W4313887934 cites W2001670860 @default.
- W4313887934 cites W2002698073 @default.
- W4313887934 cites W2004891222 @default.
- W4313887934 cites W2006579769 @default.
- W4313887934 cites W2007603569 @default.
- W4313887934 cites W2009140393 @default.
- W4313887934 cites W2011096612 @default.
- W4313887934 cites W2011687861 @default.
- W4313887934 cites W2012962381 @default.
- W4313887934 cites W2018192635 @default.
- W4313887934 cites W2021565536 @default.
- W4313887934 cites W2021743398 @default.
- W4313887934 cites W2027342158 @default.
- W4313887934 cites W2029353869 @default.
- W4313887934 cites W2031812779 @default.
- W4313887934 cites W2032911882 @default.
- W4313887934 cites W2033618020 @default.
- W4313887934 cites W2033836017 @default.
- W4313887934 cites W2034351801 @default.
- W4313887934 cites W2035634736 @default.
- W4313887934 cites W2039215669 @default.
- W4313887934 cites W2042531263 @default.
- W4313887934 cites W2050222325 @default.
- W4313887934 cites W2053686577 @default.
- W4313887934 cites W2059915932 @default.
- W4313887934 cites W2060144270 @default.
- W4313887934 cites W2060954315 @default.
- W4313887934 cites W2066236572 @default.
- W4313887934 cites W2067449053 @default.
- W4313887934 cites W2069453594 @default.
- W4313887934 cites W2072591082 @default.
- W4313887934 cites W2073938143 @default.
- W4313887934 cites W2077436740 @default.
- W4313887934 cites W2078060536 @default.
- W4313887934 cites W2079472033 @default.
- W4313887934 cites W2083536957 @default.
- W4313887934 cites W2088260828 @default.
- W4313887934 cites W2088581960 @default.
- W4313887934 cites W2090789702 @default.
- W4313887934 cites W2094480843 @default.
- W4313887934 cites W2099431941 @default.
- W4313887934 cites W2102731543 @default.
- W4313887934 cites W2104537787 @default.
- W4313887934 cites W2109071232 @default.
- W4313887934 cites W2110471949 @default.
- W4313887934 cites W2118453722 @default.
- W4313887934 cites W2119695863 @default.
- W4313887934 cites W2122135370 @default.
- W4313887934 cites W2122156001 @default.
- W4313887934 cites W2122208901 @default.
- W4313887934 cites W2124041794 @default.
- W4313887934 cites W2125347681 @default.
- W4313887934 cites W2129746041 @default.
- W4313887934 cites W2130008150 @default.
- W4313887934 cites W2134330291 @default.
- W4313887934 cites W2135835127 @default.
- W4313887934 cites W2137136115 @default.
- W4313887934 cites W2142328047 @default.