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- W4313888006 abstract "Anterior-posterior axis formation regulated by the distal visceral endoderm (DVE) and anterior visceral endoderm (AVE) is essential for peri-implantation embryogenesis. However, the principles of the origin and specialization of DVE and AVE remain elusive. Here, with single-cell transcriptome analysis and pseudotime prediction, we show that DVE and AVE independently originate from the specialized primary endoderm in mouse blastocysts. Along distinct developmental paths, these two lineages, respectively, undergo four representative states with stage-specific transcriptional patterns around implantation. Further comparative analysis shows that AVE, but not DVE, is detected in human and non-human primate embryos, defining differences in polarity formation across species. Moreover, stem cell-assembled human blastoids lack DVE or AVE precursors, implying that additional induction of stem cells with DVE/AVE potential could promote the current embryo-like models and their post-implantation growth. Our work provides insight into understanding of embryonic polarity formation and early mammalian development." @default.
- W4313888006 created "2023-01-10" @default.
- W4313888006 creator A5047070284 @default.
- W4313888006 creator A5048895170 @default.
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- W4313888006 creator A5060002817 @default.
- W4313888006 creator A5064031029 @default.
- W4313888006 date "2023-01-01" @default.
- W4313888006 modified "2023-10-16" @default.
- W4313888006 title "Decoding anterior-posterior axis emergence among mouse, monkey, and human embryos" @default.
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- W4313888006 doi "https://doi.org/10.1016/j.devcel.2022.12.004" @default.
- W4313888006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36626872" @default.
- W4313888006 hasPublicationYear "2023" @default.
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