Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313888311> ?p ?o ?g. }
- W4313888311 endingPage "108132" @default.
- W4313888311 startingPage "108132" @default.
- W4313888311 abstract "DNA-encoded chemical libraries technology has become a novel approach to finding hit compounds in early drug discovery. The chemical space in a DEL would be expanded to realize its full potential, especially when integrating privileged scaffold dihydroquinazoline that has demonstrated a variety of diverse bioactivities. Driven by the requirement of parallel combinatorial synthesis, we here report a facile synthesis of on-DNA dihydroquinazolinone from aldehyde and anthranilamide. This DNA-compatible reaction was promoted by antimony trichloride, which has been proven to accelerate the reaction and improve conversions. Notably, the broad substrate scope of aldehydes and anthranilamides was explored under the mild reaction condition to achieve moderate-to-excellent conversion yields. We further applied the reaction into on-DNA macrocyclization, obtaining macrocycles embedded dihydroquinazolinone scaffold in synthetically useful conversion yields." @default.
- W4313888311 created "2023-01-10" @default.
- W4313888311 creator A5003870028 @default.
- W4313888311 creator A5005355993 @default.
- W4313888311 creator A5009521793 @default.
- W4313888311 creator A5027898809 @default.
- W4313888311 creator A5029095757 @default.
- W4313888311 creator A5039032360 @default.
- W4313888311 creator A5051105927 @default.
- W4313888311 creator A5077643534 @default.
- W4313888311 date "2023-08-01" @default.
- W4313888311 modified "2023-10-16" @default.
- W4313888311 title "Antimony salt-promoted cyclization facilitating on-DNA syntheses of dihydroquinazolinone derivatives and its applications" @default.
- W4313888311 cites W1968995375 @default.
- W4313888311 cites W2017423606 @default.
- W4313888311 cites W2017937986 @default.
- W4313888311 cites W2048361834 @default.
- W4313888311 cites W2053478708 @default.
- W4313888311 cites W2096216335 @default.
- W4313888311 cites W2155475165 @default.
- W4313888311 cites W2159059125 @default.
- W4313888311 cites W2210334928 @default.
- W4313888311 cites W2286829287 @default.
- W4313888311 cites W2461339154 @default.
- W4313888311 cites W2557936227 @default.
- W4313888311 cites W2569631735 @default.
- W4313888311 cites W2584580415 @default.
- W4313888311 cites W2592790009 @default.
- W4313888311 cites W2598535577 @default.
- W4313888311 cites W2606821098 @default.
- W4313888311 cites W2624362495 @default.
- W4313888311 cites W2749588944 @default.
- W4313888311 cites W2770991451 @default.
- W4313888311 cites W2792466565 @default.
- W4313888311 cites W2805512669 @default.
- W4313888311 cites W2928359543 @default.
- W4313888311 cites W2944922217 @default.
- W4313888311 cites W2949576014 @default.
- W4313888311 cites W2966262581 @default.
- W4313888311 cites W2981035632 @default.
- W4313888311 cites W2982489572 @default.
- W4313888311 cites W2991203138 @default.
- W4313888311 cites W2998882116 @default.
- W4313888311 cites W2998941884 @default.
- W4313888311 cites W3005945993 @default.
- W4313888311 cites W3014863377 @default.
- W4313888311 cites W3016762617 @default.
- W4313888311 cites W3083513001 @default.
- W4313888311 cites W3090031851 @default.
- W4313888311 cites W3092211024 @default.
- W4313888311 cites W3095217989 @default.
- W4313888311 cites W3115530920 @default.
- W4313888311 cites W3132548504 @default.
- W4313888311 cites W3136049665 @default.
- W4313888311 cites W3144172399 @default.
- W4313888311 cites W3163765390 @default.
- W4313888311 cites W3167708565 @default.
- W4313888311 cites W3194821487 @default.
- W4313888311 cites W3199255596 @default.
- W4313888311 cites W3200446854 @default.
- W4313888311 cites W3211181903 @default.
- W4313888311 cites W3212369199 @default.
- W4313888311 cites W3213776049 @default.
- W4313888311 cites W3214322589 @default.
- W4313888311 cites W4200013295 @default.
- W4313888311 cites W4205885823 @default.
- W4313888311 cites W4206125302 @default.
- W4313888311 cites W4207047207 @default.
- W4313888311 cites W4210526883 @default.
- W4313888311 cites W4210670803 @default.
- W4313888311 cites W4213333721 @default.
- W4313888311 cites W4220866598 @default.
- W4313888311 cites W4224924664 @default.
- W4313888311 cites W4233184616 @default.
- W4313888311 cites W4282980955 @default.
- W4313888311 cites W4294287035 @default.
- W4313888311 cites W4297242940 @default.
- W4313888311 cites W4383497367 @default.
- W4313888311 cites W589574422 @default.
- W4313888311 doi "https://doi.org/10.1016/j.cclet.2023.108132" @default.
- W4313888311 hasPublicationYear "2023" @default.
- W4313888311 type Work @default.
- W4313888311 citedByCount "5" @default.
- W4313888311 countsByYear W43138883112023 @default.
- W4313888311 crossrefType "journal-article" @default.
- W4313888311 hasAuthorship W4313888311A5003870028 @default.
- W4313888311 hasAuthorship W4313888311A5005355993 @default.
- W4313888311 hasAuthorship W4313888311A5009521793 @default.
- W4313888311 hasAuthorship W4313888311A5027898809 @default.
- W4313888311 hasAuthorship W4313888311A5029095757 @default.
- W4313888311 hasAuthorship W4313888311A5039032360 @default.
- W4313888311 hasAuthorship W4313888311A5051105927 @default.
- W4313888311 hasAuthorship W4313888311A5077643534 @default.
- W4313888311 hasConcept C161790260 @default.
- W4313888311 hasConcept C171250308 @default.
- W4313888311 hasConcept C178790620 @default.
- W4313888311 hasConcept C185592680 @default.
- W4313888311 hasConcept C18903297 @default.