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- W4313888888 abstract "Triple negative breast cancer (TNBC) is a specific breast cancer subtype, and poor prognosis is associated to this tumour when it is in the metastatic form. The overexpression of the inducible Nitric Oxide Synthase (iNOS) is considered a predictor of poor outcome in TNBC patients, and this enzyme is reported as a valuable molecular target to compromise TNBC progression. In this work, new amidines containing a benzenesulfonamide group were designed and synthesized as selective iNOS inhibitors. An in vitro biological evaluation was performed to assess compounds activity against both the inducible and constitutive NOSs. The most interesting compounds 1b and 2b were evaluated on MDA-MB-231 cells as antiproliferative agents, and 1b capability to counteract cell migration was also studied. Finally, an in-depth docking study was performed to shed light on the observed potency and selectivity of action of the most promising compounds." @default.
- W4313888888 created "2023-01-10" @default.
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- W4313888888 date "2023-02-01" @default.
- W4313888888 modified "2023-10-18" @default.
- W4313888888 title "New amidine-benzenesulfonamides as iNOS inhibitors for the therapy of the triple negative breast cancer" @default.
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- W4313888888 doi "https://doi.org/10.1016/j.ejmech.2023.115112" @default.
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