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- W4313890069 endingPage "634" @default.
- W4313890069 startingPage "634" @default.
- W4313890069 abstract "Toll-like receptor 7 (TLR7) is a class of pattern recognition receptors (PRRs) recognizing the pathogen-associated elements and damage and as such is a major player in the innate immune system. TLR7 triggers the release of pro-inflammatory cytokines or type-I interferons (IFN), which is essential for immunoregulation. Increasing reports also highlight that the abnormal activation of endosomal TLR7 is implicated in various immune-related diseases, carcinogenesis as well as the proliferation of human immunodeficiency virus (HIV). Hence, the design and development of potent and selective TLR7 antagonists based on small molecules or oligonucleotides may offer new tools for the prevention and management of such diseases. In this review, we offer an updated overview of the main structural features and therapeutic potential of small-molecule antagonists of TLR7. Various heterocyclic scaffolds targeting TLR7 binding sites are presented: pyrazoloquinoxaline, quinazoline, purine, imidazopyridine, pyridone, benzanilide, pyrazolopyrimidine/pyridine, benzoxazole, indazole, indole, and quinoline. Additionally, their structure-activity relationships (SAR) studies associated with biological activities and protein binding modes are introduced." @default.
- W4313890069 created "2023-01-10" @default.
- W4313890069 creator A5034940286 @default.
- W4313890069 creator A5047023313 @default.
- W4313890069 creator A5070352142 @default.
- W4313890069 date "2023-01-07" @default.
- W4313890069 modified "2023-09-30" @default.
- W4313890069 title "Recent Advances on Small-Molecule Antagonists Targeting TLR7" @default.
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