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- W4313890762 endingPage "386" @default.
- W4313890762 startingPage "386" @default.
- W4313890762 abstract "Despite recent therapeutic advances, non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related death. Signal transducer and activator of transcription 3 (STAT3) is a transcription factor (TF) with multiple tumor-promoting effects in NSCLC, including proliferation, anti-apoptosis, angiogenesis, invasion, metastasis, immunosuppression, and drug resistance. Recent studies suggest that STAT3 activation contributes to resistance to immune checkpoint inhibitors. Thus, STAT3 represents an attractive target whose pharmacological modulation in NSCLC may assist in enhancing the efficacy of or overcoming resistance to immune checkpoint inhibitors. In this review, we discuss the biological mechanisms through which STAT3 inhibition synergizes with or overcomes resistance to immune checkpoint inhibitors and highlight the therapeutic strategy of using drugs that target STAT3 as potential combination partners for immune checkpoint inhibitors in the management of NSCLC patients." @default.
- W4313890762 created "2023-01-10" @default.
- W4313890762 creator A5035979141 @default.
- W4313890762 creator A5049588656 @default.
- W4313890762 creator A5077783091 @default.
- W4313890762 date "2023-01-06" @default.
- W4313890762 modified "2023-09-26" @default.
- W4313890762 title "Combining STAT3-Targeting Agents with Immune Checkpoint Inhibitors in NSCLC" @default.
- W4313890762 cites W1540838664 @default.
- W4313890762 cites W1618337835 @default.
- W4313890762 cites W1821858011 @default.
- W4313890762 cites W1919712230 @default.
- W4313890762 cites W1960585934 @default.
- W4313890762 cites W1973994279 @default.
- W4313890762 cites W1978857579 @default.
- W4313890762 cites W1979335806 @default.
- W4313890762 cites W1979562553 @default.
- W4313890762 cites W1991616147 @default.
- W4313890762 cites W1999468766 @default.
- W4313890762 cites W2015317524 @default.
- W4313890762 cites W2016707829 @default.
- W4313890762 cites W2018233112 @default.
- W4313890762 cites W2022956052 @default.
- W4313890762 cites W2028544780 @default.
- W4313890762 cites W2030726748 @default.
- W4313890762 cites W2033899321 @default.
- W4313890762 cites W2040736784 @default.
- W4313890762 cites W2041168245 @default.
- W4313890762 cites W2045749875 @default.
- W4313890762 cites W2046764077 @default.
- W4313890762 cites W2050394518 @default.
- W4313890762 cites W2051083170 @default.
- W4313890762 cites W2053055233 @default.
- W4313890762 cites W2053782627 @default.
- W4313890762 cites W2060296667 @default.
- W4313890762 cites W2078165843 @default.
- W4313890762 cites W2087687370 @default.
- W4313890762 cites W2095110084 @default.
- W4313890762 cites W2096639900 @default.
- W4313890762 cites W2102365935 @default.
- W4313890762 cites W2104350866 @default.
- W4313890762 cites W2114292839 @default.
- W4313890762 cites W2120010406 @default.
- W4313890762 cites W2120164335 @default.
- W4313890762 cites W2126878117 @default.
- W4313890762 cites W2134259065 @default.
- W4313890762 cites W2137158350 @default.
- W4313890762 cites W2138705226 @default.
- W4313890762 cites W2138880254 @default.
- W4313890762 cites W2148181856 @default.
- W4313890762 cites W2149479626 @default.
- W4313890762 cites W2151683823 @default.
- W4313890762 cites W2156239323 @default.
- W4313890762 cites W2167259432 @default.
- W4313890762 cites W2168478794 @default.
- W4313890762 cites W2168635759 @default.
- W4313890762 cites W2281804634 @default.
- W4313890762 cites W2341757884 @default.
- W4313890762 cites W2343821765 @default.
- W4313890762 cites W2400514548 @default.
- W4313890762 cites W2465860350 @default.
- W4313890762 cites W2494860457 @default.
- W4313890762 cites W2512136042 @default.
- W4313890762 cites W2513437066 @default.
- W4313890762 cites W2538232731 @default.
- W4313890762 cites W2547668080 @default.
- W4313890762 cites W2552750859 @default.
- W4313890762 cites W2574482078 @default.
- W4313890762 cites W2591374950 @default.
- W4313890762 cites W2735213270 @default.
- W4313890762 cites W2750896603 @default.
- W4313890762 cites W2786987313 @default.
- W4313890762 cites W2788742274 @default.
- W4313890762 cites W2796025078 @default.
- W4313890762 cites W2801806547 @default.
- W4313890762 cites W2805942737 @default.
- W4313890762 cites W2807709793 @default.
- W4313890762 cites W2892635078 @default.
- W4313890762 cites W2892890999 @default.
- W4313890762 cites W2913496992 @default.
- W4313890762 cites W2954331030 @default.
- W4313890762 cites W2972778323 @default.
- W4313890762 cites W2994620676 @default.
- W4313890762 cites W2997163261 @default.
- W4313890762 cites W2997921831 @default.
- W4313890762 cites W3033095316 @default.
- W4313890762 cites W3039544508 @default.
- W4313890762 cites W3049389308 @default.
- W4313890762 cites W3084494759 @default.
- W4313890762 cites W3089713540 @default.
- W4313890762 cites W3128646645 @default.
- W4313890762 cites W3138556548 @default.
- W4313890762 cites W3152400186 @default.
- W4313890762 cites W3178510225 @default.
- W4313890762 cites W4200230776 @default.
- W4313890762 cites W4240928171 @default.
- W4313890762 cites W4288684469 @default.
- W4313890762 cites W4293101613 @default.