Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313890914> ?p ?o ?g. }
- W4313890914 endingPage "156" @default.
- W4313890914 startingPage "156" @default.
- W4313890914 abstract "Limited efforts have been invested in exploring the interaction effects between genetic factors and gut microbiota on neuroticism and general happiness. The polygenic risk scores (PRS) of gut microbiota were calculated from individual-level genotype data of the UK Biobank cohort. Linear regression models were then used to assess the associations between individual PRS of gut microbiota and mental traits and interaction analysis was performed by PLINK2.0. KOBAS-i was used to conduct gene ontology (GO) enrichment analysis of the identified genes. We observed suggestive significant associations between neuroticism and PRS for the genus Bifidobacterium (rank-normal transformation, RNT) (beta = -1.10, P = 4.16 × 10-3) and the genus Desulfovibrio (RNT) (beta = 0.54, P = 7.46 × 10-3). PRS for the genus Bifidobacterium (hurdle binary, HB) (beta = 1.99, P = 5.24 × 10-3) and the genus Clostridium (RNT) (beta = 1.26, P = 9.27 × 10-3) were found to be suggestive positively associated with general happiness. Interaction analysis identified several significant genes that interacted with gut microbiota, such as RORA (rs575949009, beta = -45.00, P = 1.82 × 10-9) for neuroticism and ASTN2 (rs36005728, beta = 19.15, P = 3.37 × 10-8) for general happiness. Our study results support the genetic effects of gut microbiota on the development of neuroticism and general happiness." @default.
- W4313890914 created "2023-01-10" @default.
- W4313890914 creator A5006863860 @default.
- W4313890914 creator A5008011094 @default.
- W4313890914 creator A5015048746 @default.
- W4313890914 creator A5029811588 @default.
- W4313890914 creator A5033269764 @default.
- W4313890914 creator A5042467158 @default.
- W4313890914 creator A5045197865 @default.
- W4313890914 creator A5048101049 @default.
- W4313890914 creator A5061159630 @default.
- W4313890914 creator A5077942573 @default.
- W4313890914 creator A5090725127 @default.
- W4313890914 date "2023-01-06" @default.
- W4313890914 modified "2023-09-26" @default.
- W4313890914 title "Evaluating the Genetic Effects of Gut Microbiota on the Development of Neuroticism and General Happiness: A Polygenic Score Analysis and Interaction Study Using UK Biobank Data" @default.
- W4313890914 cites W1603465697 @default.
- W4313890914 cites W1609434270 @default.
- W4313890914 cites W1914301979 @default.
- W4313890914 cites W1968034907 @default.
- W4313890914 cites W1972112058 @default.
- W4313890914 cites W1981500982 @default.
- W4313890914 cites W1985564976 @default.
- W4313890914 cites W1989328589 @default.
- W4313890914 cites W1990065442 @default.
- W4313890914 cites W1997537641 @default.
- W4313890914 cites W1998585277 @default.
- W4313890914 cites W2011039340 @default.
- W4313890914 cites W2012490955 @default.
- W4313890914 cites W2021704663 @default.
- W4313890914 cites W2032523288 @default.
- W4313890914 cites W2033829415 @default.
- W4313890914 cites W2050582614 @default.
- W4313890914 cites W2057381986 @default.
- W4313890914 cites W2057828422 @default.
- W4313890914 cites W2066179547 @default.
- W4313890914 cites W2071644822 @default.
- W4313890914 cites W2073062083 @default.
- W4313890914 cites W2081092705 @default.
- W4313890914 cites W2082704080 @default.
- W4313890914 cites W2099085143 @default.
- W4313890914 cites W2123097904 @default.
- W4313890914 cites W2126824241 @default.
- W4313890914 cites W2126838833 @default.
- W4313890914 cites W2137633946 @default.
- W4313890914 cites W2157105430 @default.
- W4313890914 cites W2161633633 @default.
- W4313890914 cites W2162204400 @default.
- W4313890914 cites W2163924952 @default.
- W4313890914 cites W2168271199 @default.
- W4313890914 cites W2529265647 @default.
- W4313890914 cites W2540966784 @default.
- W4313890914 cites W2560351606 @default.
- W4313890914 cites W2574432813 @default.
- W4313890914 cites W2625502155 @default.
- W4313890914 cites W2736536999 @default.
- W4313890914 cites W2780087044 @default.
- W4313890914 cites W2793786682 @default.
- W4313890914 cites W2891851874 @default.
- W4313890914 cites W2895486342 @default.
- W4313890914 cites W2906951867 @default.
- W4313890914 cites W2912654919 @default.
- W4313890914 cites W2946120712 @default.
- W4313890914 cites W2947170763 @default.
- W4313890914 cites W2948620521 @default.
- W4313890914 cites W2950708207 @default.
- W4313890914 cites W2950885009 @default.
- W4313890914 cites W2995439326 @default.
- W4313890914 cites W3035975458 @default.
- W4313890914 cites W3108868751 @default.
- W4313890914 cites W3127267391 @default.
- W4313890914 cites W3133877026 @default.
- W4313890914 cites W3157951893 @default.
- W4313890914 cites W3164271582 @default.
- W4313890914 cites W3207744615 @default.
- W4313890914 cites W3217089091 @default.
- W4313890914 cites W4200137367 @default.
- W4313890914 cites W4210510257 @default.
- W4313890914 cites W4224009687 @default.
- W4313890914 cites W4288684320 @default.
- W4313890914 cites W4294204259 @default.
- W4313890914 cites W4307939651 @default.
- W4313890914 cites W4308662248 @default.
- W4313890914 cites W4309531448 @default.
- W4313890914 cites W4309609809 @default.
- W4313890914 cites W4309891391 @default.
- W4313890914 cites W4310699971 @default.
- W4313890914 cites W4311654199 @default.
- W4313890914 cites W947474839 @default.
- W4313890914 doi "https://doi.org/10.3390/genes14010156" @default.
- W4313890914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36672898" @default.
- W4313890914 hasPublicationYear "2023" @default.
- W4313890914 type Work @default.
- W4313890914 citedByCount "0" @default.
- W4313890914 crossrefType "journal-article" @default.
- W4313890914 hasAuthorship W4313890914A5006863860 @default.
- W4313890914 hasAuthorship W4313890914A5008011094 @default.
- W4313890914 hasAuthorship W4313890914A5015048746 @default.