Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313890963> ?p ?o ?g. }
- W4313890963 endingPage "1234" @default.
- W4313890963 startingPage "1234" @default.
- W4313890963 abstract "Hypoxia is a critical condition that governs survival, self-renewal, quiescence, metabolic shift and refractoriness to leukemic stem cell (LSC) therapy. The present study aims to investigate the hypoxia-driven regulation of the mammalian Target of the Rapamycin-2 (mTORC2) complex to unravel it as a novel potential target in chronic myeloid leukemia (CML) therapeutic strategies. After inducing hypoxia in a CML cell line model, we investigated the activities of mTORC1 and mTORC2. Surprisingly, we detected a significant activation of mTORC2 at the expense of mTORC1, accompanied by the nuclear localization of the main substrate phospho-Akt (Ser473). Moreover, the Gene Ontology analysis of CML patients' CD34+ cells showed enrichment in the mTORC2 signature, further strengthening our data. The deregulation of mTOR complexes highlights how hypoxia could be crucial in CML development. In conclusion, we propose a mechanism by which CML cells residing under a low-oxygen tension, i.e., in the leukemia quiescent LSCs, singularly regulate the mTORC2 and its downstream effectors." @default.
- W4313890963 created "2023-01-10" @default.
- W4313890963 creator A5006463761 @default.
- W4313890963 creator A5025309980 @default.
- W4313890963 creator A5025675788 @default.
- W4313890963 creator A5034510628 @default.
- W4313890963 creator A5041174491 @default.
- W4313890963 creator A5043876644 @default.
- W4313890963 creator A5047604073 @default.
- W4313890963 creator A5053219117 @default.
- W4313890963 creator A5059636347 @default.
- W4313890963 creator A5069626442 @default.
- W4313890963 creator A5076449178 @default.
- W4313890963 date "2023-01-08" @default.
- W4313890963 modified "2023-09-26" @default.
- W4313890963 title "mTORC2 Is Activated under Hypoxia and Could Support Chronic Myeloid Leukemia Stem Cells" @default.
- W4313890963 cites W1490080803 @default.
- W4313890963 cites W1677499164 @default.
- W4313890963 cites W1841276786 @default.
- W4313890963 cites W1968747503 @default.
- W4313890963 cites W1969752146 @default.
- W4313890963 cites W1973310114 @default.
- W4313890963 cites W1981168682 @default.
- W4313890963 cites W1987239635 @default.
- W4313890963 cites W1989617311 @default.
- W4313890963 cites W1993696110 @default.
- W4313890963 cites W2009397177 @default.
- W4313890963 cites W2010356452 @default.
- W4313890963 cites W2010400641 @default.
- W4313890963 cites W2016726636 @default.
- W4313890963 cites W2025253425 @default.
- W4313890963 cites W2033771177 @default.
- W4313890963 cites W2035751873 @default.
- W4313890963 cites W2037572151 @default.
- W4313890963 cites W2039346134 @default.
- W4313890963 cites W2045201777 @default.
- W4313890963 cites W2047057500 @default.
- W4313890963 cites W2051485323 @default.
- W4313890963 cites W2054978547 @default.
- W4313890963 cites W2058236541 @default.
- W4313890963 cites W2060749382 @default.
- W4313890963 cites W2068943550 @default.
- W4313890963 cites W2070050178 @default.
- W4313890963 cites W2074516296 @default.
- W4313890963 cites W2081098333 @default.
- W4313890963 cites W2081869055 @default.
- W4313890963 cites W2096086497 @default.
- W4313890963 cites W2099283141 @default.
- W4313890963 cites W2114956843 @default.
- W4313890963 cites W2115655607 @default.
- W4313890963 cites W2120165607 @default.
- W4313890963 cites W2127063807 @default.
- W4313890963 cites W2127259700 @default.
- W4313890963 cites W2130396048 @default.
- W4313890963 cites W2143112776 @default.
- W4313890963 cites W2156454971 @default.
- W4313890963 cites W2156564520 @default.
- W4313890963 cites W2167177526 @default.
- W4313890963 cites W2198733978 @default.
- W4313890963 cites W2253051214 @default.
- W4313890963 cites W2338299098 @default.
- W4313890963 cites W2507283296 @default.
- W4313890963 cites W2535462468 @default.
- W4313890963 cites W2564694582 @default.
- W4313890963 cites W2589091658 @default.
- W4313890963 cites W2593816418 @default.
- W4313890963 cites W2605465471 @default.
- W4313890963 cites W2606513998 @default.
- W4313890963 cites W2610808603 @default.
- W4313890963 cites W2620723097 @default.
- W4313890963 cites W2620808717 @default.
- W4313890963 cites W2730832359 @default.
- W4313890963 cites W2737946118 @default.
- W4313890963 cites W2778000807 @default.
- W4313890963 cites W2782944579 @default.
- W4313890963 cites W2783732652 @default.
- W4313890963 cites W2788511495 @default.
- W4313890963 cites W2792383110 @default.
- W4313890963 cites W2807575739 @default.
- W4313890963 cites W2885655350 @default.
- W4313890963 cites W2943001511 @default.
- W4313890963 cites W2945573573 @default.
- W4313890963 cites W2955485789 @default.
- W4313890963 cites W2971992069 @default.
- W4313890963 cites W2982299700 @default.
- W4313890963 cites W2999294672 @default.
- W4313890963 cites W3000733604 @default.
- W4313890963 cites W3092769938 @default.
- W4313890963 cites W3119122155 @default.
- W4313890963 cites W3176712441 @default.
- W4313890963 cites W3177731011 @default.
- W4313890963 cites W3187724078 @default.
- W4313890963 cites W3196967738 @default.
- W4313890963 cites W3214005369 @default.
- W4313890963 cites W4233120011 @default.
- W4313890963 cites W4280560201 @default.
- W4313890963 cites W628038580 @default.
- W4313890963 doi "https://doi.org/10.3390/ijms24021234" @default.