Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313891441> ?p ?o ?g. }
- W4313891441 endingPage "1118" @default.
- W4313891441 startingPage "1118" @default.
- W4313891441 abstract "Neutrophil extracellular traps (NETs) play important roles in host immunity, as there is increasing evidence of their contribution to the progression of several types of cancers even though their role in colorectal cancers (CRCs) remains unclear. To investigate the clinical relevance of NETs in CRCs, we examined the expression of citrullinated histone H3 using immunohistochemistry and preoperative serum myeloperoxidase-DNA complexes in CRC patients using an enzyme-linked immunosorbent assay. High expression of intratumoral or systemic NETs was found to correlate with poor relapse-free survival (RFS), for which it is an independent prognostic factor. In vitro investigations of CRC cells (HCT116, HT29) revealed that NETs did not affect their proliferation but did promote the migration of CRC cells mediated by neutrophil elastase (NE) released during NETosis to increase extracellular signal-regulated kinase (ERK) activity. In vivo experiments using nude mice (KSN/slc) revealed that NE inhibition suppressed liver metastases in CRC cells, although it did not affect the growth of subcutaneously implanted tumors. Taken together, these results suggest that NET formation correlates with poor prognoses of patients with CRC and that the inhibition of NE could be a potential therapy for CRC metastases." @default.
- W4313891441 created "2023-01-10" @default.
- W4313891441 creator A5003865151 @default.
- W4313891441 creator A5007850735 @default.
- W4313891441 creator A5014358248 @default.
- W4313891441 creator A5020801534 @default.
- W4313891441 creator A5024088705 @default.
- W4313891441 creator A5035635762 @default.
- W4313891441 creator A5037771875 @default.
- W4313891441 creator A5038106659 @default.
- W4313891441 creator A5044897580 @default.
- W4313891441 creator A5045106477 @default.
- W4313891441 creator A5048815327 @default.
- W4313891441 creator A5050855780 @default.
- W4313891441 creator A5059656401 @default.
- W4313891441 creator A5069964282 @default.
- W4313891441 date "2023-01-06" @default.
- W4313891441 modified "2023-10-18" @default.
- W4313891441 title "Neutrophil Extracellular Traps Promote Metastases of Colorectal Cancers through Activation of ERK Signaling by Releasing Neutrophil Elastase" @default.
- W4313891441 cites W1494491432 @default.
- W4313891441 cites W1629665956 @default.
- W4313891441 cites W1872328052 @default.
- W4313891441 cites W1963562976 @default.
- W4313891441 cites W1977550761 @default.
- W4313891441 cites W1982243149 @default.
- W4313891441 cites W1982906652 @default.
- W4313891441 cites W1985130705 @default.
- W4313891441 cites W1991365889 @default.
- W4313891441 cites W2002157461 @default.
- W4313891441 cites W2003377449 @default.
- W4313891441 cites W2011145349 @default.
- W4313891441 cites W2013630409 @default.
- W4313891441 cites W2027282723 @default.
- W4313891441 cites W2039518851 @default.
- W4313891441 cites W2043756611 @default.
- W4313891441 cites W2055380229 @default.
- W4313891441 cites W2062265555 @default.
- W4313891441 cites W2065411406 @default.
- W4313891441 cites W2072731788 @default.
- W4313891441 cites W2072852488 @default.
- W4313891441 cites W2085458222 @default.
- W4313891441 cites W2099547846 @default.
- W4313891441 cites W2101037339 @default.
- W4313891441 cites W2103965486 @default.
- W4313891441 cites W2104934425 @default.
- W4313891441 cites W2113974479 @default.
- W4313891441 cites W2115347009 @default.
- W4313891441 cites W2115959782 @default.
- W4313891441 cites W2140995313 @default.
- W4313891441 cites W2141815918 @default.
- W4313891441 cites W2147489608 @default.
- W4313891441 cites W2149026115 @default.
- W4313891441 cites W2152351598 @default.
- W4313891441 cites W2154458783 @default.
- W4313891441 cites W2163581770 @default.
- W4313891441 cites W2170274551 @default.
- W4313891441 cites W2237361742 @default.
- W4313891441 cites W2301131921 @default.
- W4313891441 cites W2534066964 @default.
- W4313891441 cites W2560738829 @default.
- W4313891441 cites W2581055553 @default.
- W4313891441 cites W2586679548 @default.
- W4313891441 cites W2751174913 @default.
- W4313891441 cites W2769277374 @default.
- W4313891441 cites W2770699872 @default.
- W4313891441 cites W2808590765 @default.
- W4313891441 cites W2890499629 @default.
- W4313891441 cites W2894451493 @default.
- W4313891441 cites W2901246966 @default.
- W4313891441 cites W2904189039 @default.
- W4313891441 cites W2912016163 @default.
- W4313891441 cites W2913248654 @default.
- W4313891441 cites W2924629148 @default.
- W4313891441 cites W2963080746 @default.
- W4313891441 cites W2963309491 @default.
- W4313891441 cites W2963579838 @default.
- W4313891441 cites W2966039277 @default.
- W4313891441 cites W2966710588 @default.
- W4313891441 cites W2972917954 @default.
- W4313891441 cites W2998053729 @default.
- W4313891441 cites W3004238134 @default.
- W4313891441 cites W3005652493 @default.
- W4313891441 cites W3015593940 @default.
- W4313891441 cites W3016135526 @default.
- W4313891441 cites W3020045638 @default.
- W4313891441 cites W3034318868 @default.
- W4313891441 cites W3036759197 @default.
- W4313891441 cites W3037554597 @default.
- W4313891441 cites W3092902684 @default.
- W4313891441 cites W3095535158 @default.
- W4313891441 cites W3098112929 @default.
- W4313891441 cites W3120670329 @default.
- W4313891441 cites W3128646645 @default.
- W4313891441 cites W3168380458 @default.
- W4313891441 cites W3185474340 @default.
- W4313891441 cites W3198368127 @default.
- W4313891441 cites W3199187959 @default.
- W4313891441 cites W4210817811 @default.