FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313891508> ?p ?o ?g. }

• W4313891508 endingPage "1175" @default.
• W4313891508 startingPage "1175" @default.
• W4313891508 abstract "The skeletal muscle has a very remarkable ability to regenerate upon injury under physiological conditions; however, this regenerative capacity is strongly diminished in physio-pathological conditions, such as those present in diseased or aged muscles. Many muscular dystrophies (MDs) are characterized by aberrant inflammation due to the deregulation of both the lymphoid and myeloid cell populations and the production of pro-inflammatory cytokines. Pathological inflammation is also observed in old muscles due to a systemic change in the immune system, known as “inflammaging”. Immunomodulation represents, therefore, a promising therapeutic opportunity for different skeletal muscle conditions. However, the use of immunomodulatory drugs in the clinics presents several caveats, including their low stability in vivo, the need for high doses to obtain therapeutically relevant effects, and the presence of strong side effects. Within this context, the emerging field of nanomedicine provides the powerful tools needed to control the immune response. Nano-scale materials are currently being explored as biocarriers to release immunomodulatory agents in the damaged tissues, allowing therapeutic doses with limited off-target effects. In addition, the intrinsic immunomodulatory properties of some nanomaterials offer further opportunities for intervention that still need to be systematically explored. Here we exhaustively review the state-of-the-art regarding the use of nano-sized materials to modulate the aberrant immune response that characterizes some physio-pathological muscle conditions, such as MDs or sarcopenia (the age-dependent loss of muscle mass). Based on our learnings from cancer and immune tolerance induction, we also discuss further opportunities, challenges, and limitations of the emerging field of nano-immunomodulation." @default.
• W4313891508 created "2023-01-10" @default.
• W4313891508 creator A5025780332 @default.
• W4313891508 creator A5040335915 @default.
• W4313891508 creator A5063697318 @default.
• W4313891508 creator A5065411322 @default.
• W4313891508 creator A5088270063 @default.
• W4313891508 date "2023-01-07" @default.
• W4313891508 modified "2023-10-18" @default.
• W4313891508 title "Nano-Immunomodulation: A New Strategy for Skeletal Muscle Diseases and Aging?" @default.
• W4313891508 cites W139379903 @default.
• W4313891508 cites W1539477086 @default.
• W4313891508 cites W1548049538 @default.
• W4313891508 cites W1574278422 @default.
• W4313891508 cites W166700135 @default.
• W4313891508 cites W1819436393 @default.
• W4313891508 cites W1922047890 @default.
• W4313891508 cites W1926551934 @default.
• W4313891508 cites W1962551563 @default.
• W4313891508 cites W1963578712 @default.
• W4313891508 cites W1966537913 @default.
• W4313891508 cites W1972187290 @default.
• W4313891508 cites W1973847028 @default.
• W4313891508 cites W1978478452 @default.
• W4313891508 cites W1978684572 @default.
• W4313891508 cites W1979173328 @default.
• W4313891508 cites W1981762720 @default.
• W4313891508 cites W1983999852 @default.
• W4313891508 cites W1998139299 @default.
• W4313891508 cites W1999353686 @default.
• W4313891508 cites W2004482801 @default.
• W4313891508 cites W2004790475 @default.
• W4313891508 cites W2008419958 @default.
• W4313891508 cites W2008747552 @default.
• W4313891508 cites W2020180085 @default.
• W4313891508 cites W2021528450 @default.
• W4313891508 cites W2022122691 @default.
• W4313891508 cites W2024470090 @default.
• W4313891508 cites W2028543411 @default.
• W4313891508 cites W2028763115 @default.
• W4313891508 cites W2029146247 @default.
• W4313891508 cites W2030190455 @default.
• W4313891508 cites W2041663579 @default.
• W4313891508 cites W2048089341 @default.
• W4313891508 cites W2050388013 @default.
• W4313891508 cites W2054847598 @default.
• W4313891508 cites W2057767029 @default.
• W4313891508 cites W2062467557 @default.
• W4313891508 cites W2064755736 @default.
• W4313891508 cites W2079614750 @default.
• W4313891508 cites W2087803244 @default.
• W4313891508 cites W2090522535 @default.
• W4313891508 cites W2092747941 @default.
• W4313891508 cites W2096302008 @default.
• W4313891508 cites W2098874403 @default.
• W4313891508 cites W2098930053 @default.
• W4313891508 cites W2098940221 @default.
• W4313891508 cites W2100356714 @default.
• W4313891508 cites W2100575982 @default.
• W4313891508 cites W2106183630 @default.
• W4313891508 cites W2108723188 @default.
• W4313891508 cites W2109401262 @default.
• W4313891508 cites W2110641805 @default.
• W4313891508 cites W2112326292 @default.
• W4313891508 cites W2113228211 @default.
• W4313891508 cites W2115361229 @default.
• W4313891508 cites W2116279332 @default.
• W4313891508 cites W2122126544 @default.
• W4313891508 cites W2123245071 @default.
• W4313891508 cites W2125488249 @default.
• W4313891508 cites W2131585324 @default.
• W4313891508 cites W2135561906 @default.
• W4313891508 cites W2142928351 @default.
• W4313891508 cites W2144067550 @default.
• W4313891508 cites W2144959011 @default.
• W4313891508 cites W2146663720 @default.
• W4313891508 cites W2148703658 @default.
• W4313891508 cites W2149152441 @default.
• W4313891508 cites W2151328705 @default.
• W4313891508 cites W2154809330 @default.
• W4313891508 cites W2156716608 @default.
• W4313891508 cites W2161946327 @default.
• W4313891508 cites W2163175900 @default.
• W4313891508 cites W2166518933 @default.
• W4313891508 cites W2169084330 @default.
• W4313891508 cites W2170313716 @default.
• W4313891508 cites W2172079193 @default.
• W4313891508 cites W2224835104 @default.
• W4313891508 cites W2255455792 @default.
• W4313891508 cites W2257350329 @default.
• W4313891508 cites W2269067703 @default.
• W4313891508 cites W2288145437 @default.
• W4313891508 cites W2342651196 @default.
• W4313891508 cites W2392158827 @default.
• W4313891508 cites W2412566760 @default.
• W4313891508 cites W2418981018 @default.
• W4313891508 cites W2419288946 @default.
• W4313891508 cites W2460239821 @default.

• next