FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313891609> ?p ?o ?g. }

• W4313891609 abstract "Although garlic polysaccharides have been found to possess anti-inflammatory activities, anti-inflammatory study on small molecule water-soluble garlic polysaccharide (WSGP) is few. In this study, a novel WSGP with a molecular weight of 1853 Da was isolated by DEAE-52 and Sephadex G-100 column and the chemical composition was identified by monosaccharide composition and methylation analysis. Furthermore, the antioxidant effects of WSGP and the potential molecular mechanisms on LPS-induced inflammatory responses in RAW264.7 macrophage cells were investigated. The results showed that WSGP has strong antioxidant activity, such as DPPH, hydroxyl, superoxide anion, ABTS radical scavenging capacity, Fe 2+ chelating ability and reducing power. Meanwhile, WSGP could considerably suppress the manufacturing of NO and the mRNA and protein expression degrees of IL-6, TNF-α, and IL-1β in LPS inspired RAW264.7 macrophages WSGP could significantly suppress the production of NO and the mRNA and protein expression levels of IL-1β, IL-6, and TNF-α in LPS stimulated RAW264.7 macrophage cells ( p &lt; 0.05). In addition, the phosphorylated IκB-α, p65, and STAT3 proteins were significantly increased in LPS-induced macrophages, while this trend was significantly reversed by WSGP treatment in a concentration-dependent manner ( p &lt; 0.05). Consequently, WSGP supplementation might reduce LPS-induced inflammatory responses by suppressing proinflammatory cytokines and NF-κB and STAT3 pathway activation. The finding of this research would give scientific guidelines for the judicious use of small molecular garlic polysaccharide in anti-inflammatory treatments." @default.
• W4313891609 created "2023-01-10" @default.
• W4313891609 creator A5022826172 @default.
• W4313891609 creator A5027211138 @default.
• W4313891609 creator A5028580564 @default.
• W4313891609 creator A5037473430 @default.
• W4313891609 creator A5040769857 @default.
• W4313891609 creator A5045479938 @default.
• W4313891609 creator A5053077664 @default.
• W4313891609 creator A5055551738 @default.
• W4313891609 creator A5066102428 @default.
• W4313891609 date "2023-01-09" @default.
• W4313891609 modified "2023-09-27" @default.
• W4313891609 title "Anti-inflammatory effects and molecular mechanisms of bioactive small molecule garlic polysaccharide" @default.
• W4313891609 cites W1797422316 @default.
• W4313891609 cites W1964379486 @default.
• W4313891609 cites W1969505605 @default.
• W4313891609 cites W1989705993 @default.
• W4313891609 cites W2004274286 @default.
• W4313891609 cites W2007769041 @default.
• W4313891609 cites W2013769856 @default.
• W4313891609 cites W2014929619 @default.
• W4313891609 cites W2018334956 @default.
• W4313891609 cites W2038883837 @default.
• W4313891609 cites W2043134487 @default.
• W4313891609 cites W2061702898 @default.
• W4313891609 cites W2077319578 @default.
• W4313891609 cites W2087104779 @default.
• W4313891609 cites W2091360431 @default.
• W4313891609 cites W2123105952 @default.
• W4313891609 cites W2160783397 @default.
• W4313891609 cites W2188591325 @default.
• W4313891609 cites W2191868279 @default.
• W4313891609 cites W2265341943 @default.
• W4313891609 cites W2272144400 @default.
• W4313891609 cites W2412237433 @default.
• W4313891609 cites W2565208283 @default.
• W4313891609 cites W2587825295 @default.
• W4313891609 cites W2605418959 @default.
• W4313891609 cites W2794629485 @default.
• W4313891609 cites W2810636402 @default.
• W4313891609 cites W2902406757 @default.
• W4313891609 cites W2903738789 @default.
• W4313891609 cites W2940979650 @default.
• W4313891609 cites W2975695919 @default.
• W4313891609 cites W2987694037 @default.
• W4313891609 cites W2988049488 @default.
• W4313891609 cites W3011324972 @default.
• W4313891609 cites W3013025666 @default.
• W4313891609 cites W3026141594 @default.
• W4313891609 cites W3042132356 @default.
• W4313891609 cites W3094472824 @default.
• W4313891609 cites W3164605723 @default.
• W4313891609 cites W3166578584 @default.
• W4313891609 cites W3195536851 @default.
• W4313891609 cites W3199494315 @default.
• W4313891609 cites W3205994876 @default.
• W4313891609 cites W3207622819 @default.
• W4313891609 cites W3215398447 @default.
• W4313891609 cites W4292578101 @default.
• W4313891609 doi "https://doi.org/10.3389/fnut.2022.1092873" @default.
• W4313891609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36698476" @default.
• W4313891609 hasPublicationYear "2023" @default.
• W4313891609 type Work @default.
• W4313891609 citedByCount "1" @default.
• W4313891609 countsByYear W43138916092023 @default.
• W4313891609 crossrefType "journal-article" @default.
• W4313891609 hasAuthorship W4313891609A5022826172 @default.
• W4313891609 hasAuthorship W4313891609A5027211138 @default.
• W4313891609 hasAuthorship W4313891609A5028580564 @default.
• W4313891609 hasAuthorship W4313891609A5037473430 @default.
• W4313891609 hasAuthorship W4313891609A5040769857 @default.
• W4313891609 hasAuthorship W4313891609A5045479938 @default.
• W4313891609 hasAuthorship W4313891609A5053077664 @default.
• W4313891609 hasAuthorship W4313891609A5055551738 @default.
• W4313891609 hasAuthorship W4313891609A5066102428 @default.
• W4313891609 hasBestOaLocation W43138916091 @default.
• W4313891609 hasConcept C100817775 @default.
• W4313891609 hasConcept C163994747 @default.
• W4313891609 hasConcept C164027704 @default.
• W4313891609 hasConcept C181199279 @default.
• W4313891609 hasConcept C185592680 @default.
• W4313891609 hasConcept C203014093 @default.
• W4313891609 hasConcept C2776914184 @default.
• W4313891609 hasConcept C2778004101 @default.
• W4313891609 hasConcept C2778754761 @default.
• W4313891609 hasConcept C2780795997 @default.
• W4313891609 hasConcept C2781031786 @default.
• W4313891609 hasConcept C2781401929 @default.
• W4313891609 hasConcept C55493867 @default.
• W4313891609 hasConcept C86803240 @default.
• W4313891609 hasConceptScore W4313891609C100817775 @default.
• W4313891609 hasConceptScore W4313891609C163994747 @default.
• W4313891609 hasConceptScore W4313891609C164027704 @default.
• W4313891609 hasConceptScore W4313891609C181199279 @default.
• W4313891609 hasConceptScore W4313891609C185592680 @default.
• W4313891609 hasConceptScore W4313891609C203014093 @default.
• W4313891609 hasConceptScore W4313891609C2776914184 @default.
• W4313891609 hasConceptScore W4313891609C2778004101 @default.
• W4313891609 hasConceptScore W4313891609C2778754761 @default.

• next