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- W4313892789 endingPage "145602" @default.
- W4313892789 startingPage "145602" @default.
- W4313892789 abstract "Iron oxide nanoparticles have been one of the most widely used nanomaterials in biomedical applications. However, the incomplete understanding of the toxicity mechanisms limits their use in diagnosis and treatment processes. Many parameters are associated with their toxicity such as size, surface modification, solubility, concentration and immunogenicity. Further research needs to be done to address toxicity-related concerns and to increase its effectiveness in various applications. Herein, colloidally stable nanoparticles were prepared by coating magnetic iron oxide nanoparticles (MIONPs) with protocatechuic acid (PCA) which served as a stabilizer and a linkage for a further functional layer. A new perfusion agent with magnetic imaging capability was produced by the adsorption of biocompatible passivating agent macro-aggregated albumin (MAA) on the PCA-coated MIONPs. PCA-coated MIONPs were investigated using infrared spectroscopy, thermogravimetric analysis and dynamic light scattering while adsorption of MAA was analysed by transmission electron microscopy, Fourier-transform infrared spectroscopy and x-ray diffraction methods. Magnetic measurements of samples indicated that all samples showed superparamagnetic behaviour. Cytotoxicity results revealed that the adsorption of MAA onto PCA-coated MIONPs provided an advantage by diminishing their toxicity against the L929 mouse fibroblast cell line compared to bare Fe3O4." @default.
- W4313892789 created "2023-01-10" @default.
- W4313892789 creator A5006600196 @default.
- W4313892789 creator A5021701678 @default.
- W4313892789 creator A5032517042 @default.
- W4313892789 creator A5046494444 @default.
- W4313892789 creator A5055335442 @default.
- W4313892789 creator A5067652829 @default.
- W4313892789 date "2023-01-25" @default.
- W4313892789 modified "2023-09-24" @default.
- W4313892789 title "Agglomerated serum albumin adsorbed protocatechuic acid coated superparamagnetic iron oxide nanoparticles as a theranostic agent" @default.
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- W4313892789 doi "https://doi.org/10.1088/1361-6528/acb15b" @default.
- W4313892789 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36623313" @default.
- W4313892789 hasPublicationYear "2023" @default.