FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313893122> ?p ?o ?g. }

• W4313893122 endingPage "43" @default.
• W4313893122 startingPage "35" @default.
• W4313893122 abstract "Fibers remain undigested until they reach the colon, where some are fermented by gut microbiota, producing metabolites called short-chain fatty acids (SCFAs), such as acetate and butyrate1. SCFAs lower blood pressure in experimental models2–5, but their translational potential is unknown. Here we present the results of a phase II, randomized, placebo-controlled, double-blind cross-over trial (Australian New Zealand Clinical Trials Registry ACTRN12619000916145) using prebiotic acetylated and butyrylated high-amylose maize starch (HAMSAB) supplementation6. Twenty treatment-naive participants with hypertension were randomized to 40 g per day of HAMSAB or placebo, completing each arm for 3 weeks, with a 3-week washout period between them. The primary endpoint was a reduction in ambulatory systolic blood pressure. Secondary endpoints included changes to circulating cytokines, immune markers and gut microbiome modulation. Patients receiving the HAMSAB treatment showed a clinically relevant reduction in 24-hour systolic blood pressure independent of age, sex and body mass index without any adverse effects. HAMSAB increased levels of acetate and butyrate, shifted the microbial ecosystem and expanded the prevalence of SCFA producers. In summary, a prebiotic intervention with HAMSAB could represent a promising option to deliver SCFAs and lower blood pressure in patients with essential hypertension. In a phase II, randomized, placebo-controlled, double-blind cross-over trial, Jama et al. show that delivery of short-chain fatty acids via acetylated and butyrylated high-amylose maize starch (HAMSAB) supplementation result in a clinically relevant reduction in 24-hour systolic blood pressure in patients with essential hypertension." @default.
• W4313893122 created "2023-01-10" @default.
• W4313893122 creator A5003988683 @default.
• W4313893122 creator A5008276408 @default.
• W4313893122 creator A5016063325 @default.
• W4313893122 creator A5020837176 @default.
• W4313893122 creator A5024091611 @default.
• W4313893122 creator A5025176757 @default.
• W4313893122 creator A5028468351 @default.
• W4313893122 creator A5029791937 @default.
• W4313893122 creator A5033468509 @default.
• W4313893122 creator A5036430905 @default.
• W4313893122 creator A5039127683 @default.
• W4313893122 creator A5055903341 @default.
• W4313893122 creator A5072281936 @default.
• W4313893122 date "2023-01-09" @default.
• W4313893122 modified "2023-10-15" @default.
• W4313893122 title "Prebiotic intervention with HAMSAB in untreated essential hypertensive patients assessed in a phase II randomized trial" @default.
• W4313893122 cites W1892806331 @default.
• W4313893122 cites W1901829674 @default.
• W4313893122 cites W1978290051 @default.
• W4313893122 cites W1988821718 @default.
• W4313893122 cites W2087425451 @default.
• W4313893122 cites W2099280788 @default.
• W4313893122 cites W2110378543 @default.
• W4313893122 cites W2166171121 @default.
• W4313893122 cites W2342540743 @default.
• W4313893122 cites W2560340862 @default.
• W4313893122 cites W2603850261 @default.
• W4313893122 cites W2748155559 @default.
• W4313893122 cites W2772240339 @default.
• W4313893122 cites W2792261304 @default.
• W4313893122 cites W2799848487 @default.
• W4313893122 cites W2908210684 @default.
• W4313893122 cites W2910727162 @default.
• W4313893122 cites W2913705661 @default.
• W4313893122 cites W2963276645 @default.
• W4313893122 cites W2989232496 @default.
• W4313893122 cites W2999175750 @default.
• W4313893122 cites W3004369136 @default.
• W4313893122 cites W3007072186 @default.
• W4313893122 cites W3016557657 @default.
• W4313893122 cites W3016889019 @default.
• W4313893122 cites W3025549141 @default.
• W4313893122 cites W3035622135 @default.
• W4313893122 cites W3090618941 @default.
• W4313893122 cites W3092861045 @default.
• W4313893122 cites W3093792631 @default.
• W4313893122 cites W3115778261 @default.
• W4313893122 cites W3121840481 @default.
• W4313893122 cites W3162500967 @default.
• W4313893122 cites W3174000300 @default.
• W4313893122 cites W3174672514 @default.
• W4313893122 cites W3191253123 @default.
• W4313893122 cites W3193823764 @default.
• W4313893122 cites W3211795092 @default.
• W4313893122 cites W4200339895 @default.
• W4313893122 cites W4220657995 @default.
• W4313893122 cites W4283321484 @default.
• W4313893122 cites W4295226134 @default.
• W4313893122 doi "https://doi.org/10.1038/s44161-022-00197-4" @default.
• W4313893122 hasPublicationYear "2023" @default.
• W4313893122 type Work @default.
• W4313893122 citedByCount "14" @default.
• W4313893122 countsByYear W43138931222023 @default.
• W4313893122 crossrefType "journal-article" @default.
• W4313893122 hasAuthorship W4313893122A5003988683 @default.
• W4313893122 hasAuthorship W4313893122A5008276408 @default.
• W4313893122 hasAuthorship W4313893122A5016063325 @default.
• W4313893122 hasAuthorship W4313893122A5020837176 @default.
• W4313893122 hasAuthorship W4313893122A5024091611 @default.
• W4313893122 hasAuthorship W4313893122A5025176757 @default.
• W4313893122 hasAuthorship W4313893122A5028468351 @default.
• W4313893122 hasAuthorship W4313893122A5029791937 @default.
• W4313893122 hasAuthorship W4313893122A5033468509 @default.
• W4313893122 hasAuthorship W4313893122A5036430905 @default.
• W4313893122 hasAuthorship W4313893122A5039127683 @default.
• W4313893122 hasAuthorship W4313893122A5055903341 @default.
• W4313893122 hasAuthorship W4313893122A5072281936 @default.
• W4313893122 hasBestOaLocation W43138931221 @default.
• W4313893122 hasConcept C126322002 @default.
• W4313893122 hasConcept C142724271 @default.
• W4313893122 hasConcept C168563851 @default.
• W4313893122 hasConcept C197934379 @default.
• W4313893122 hasConcept C203092338 @default.
• W4313893122 hasConcept C204787440 @default.
• W4313893122 hasConcept C27081682 @default.
• W4313893122 hasConcept C2775850156 @default.
• W4313893122 hasConcept C2775980262 @default.
• W4313893122 hasConcept C2777097880 @default.
• W4313893122 hasConcept C31903555 @default.
• W4313893122 hasConcept C42407357 @default.
• W4313893122 hasConcept C71924100 @default.
• W4313893122 hasConcept C84393581 @default.
• W4313893122 hasConcept C86803240 @default.
• W4313893122 hasConcept C90924648 @default.
• W4313893122 hasConceptScore W4313893122C126322002 @default.
• W4313893122 hasConceptScore W4313893122C142724271 @default.

• next